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ROCK1(1-1113) [cytosol]
Stable Identifier
R-HSA-212523
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Rock1 fragment (1-1113)
Icon
Locations in the PathwayBrowser for interactor UniProt:O75116 ROCK2
Expand all
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Apoptotic execution phase (Homo sapiens)
Apoptotic cleavage of cellular proteins (Homo sapiens)
Caspase-mediated cleavage of Rock-1 (Homo sapiens)
ROCK1(1-1113) [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13464 ROCK1
Gene Names
ROCK1
Chain
initiator methionine:, chain:2-1354
Reference Genes
BioGPS Gene:6093 ROCK1
COSMIC (genes):ROCK1 ROCK1
CTD Gene:6093 ROCK1
dbSNP Gene:6093 ROCK1
ENSEMBL:ENSG00000067900 ROCK1
ENSEMBL_homo_sapiens_GENE:ENSG00000067900.9 ROCK1
HGNC:10251 ROCK1
KEGG Gene (Homo sapiens):6093 ROCK1
Monarch:6093 ROCK1
NCBI Gene:6093 ROCK1
OMIM:601702 ROCK1
UCSC:Q13464 ROCK1
Reference Transcript
RefSeq:NM_005406.2 ROCK1
Other Identifiers
11739448_s_at
11739449_s_at
11739450_x_at
1561486_PM_at
1561486_at
16854145
213044_PM_at
213044_at
214578_PM_s_at
214578_s_at
235854_PM_x_at
235854_x_at
34735_at
3775666
3775667
3775668
3775669
3775670
3775671
3775672
3775673
3775676
3800614
3800616
3800618
3800620
3800621
3800622
3800623
3800624
3800628
3800630
3800631
3800632
3800633
3800635
3800636
3800639
3800640
3800641
3800644
3800645
3800650
3800652
3800654
3800655
3800656
3800657
3800659
3800663
3800664
3800665
3800668
3800671
3800672
3800673
3800675
3800676
3800677
3800678
3800680
3800682
3800683
3800688
3800696
3800697
3800698
3800699
3800700
3800701
3800702
3800703
3800704
42928_at
6093
63397_at
8022441
83223_at
A_23_P130429
A_24_P538403
GE59160
GE615576
GE620173
GE86709
GO:0000139
GO:0000166
GO:0000278
GO:0000281
GO:0000910
GO:0001726
GO:0001837
GO:0002376
GO:0003012
GO:0003013
GO:0003180
GO:0003383
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005576
GO:0005737
GO:0005794
GO:0005814
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0006468
GO:0006914
GO:0006915
GO:0006939
GO:0006996
GO:0007010
GO:0007155
GO:0007159
GO:0007163
GO:0007165
GO:0007249
GO:0007266
GO:0008092
GO:0010494
GO:0010506
GO:0010508
GO:0010613
GO:0010628
GO:0010922
GO:0012501
GO:0016020
GO:0016071
GO:0016192
GO:0016301
GO:0016310
GO:0016525
GO:0016740
GO:0018105
GO:0019828
GO:0022614
GO:0023052
GO:0030027
GO:0030036
GO:0030154
GO:0030155
GO:0030163
GO:0030334
GO:0030866
GO:0031032
GO:0031175
GO:0031267
GO:0031410
GO:0032059
GO:0032060
GO:0032091
GO:0032956
GO:0032970
GO:0034330
GO:0034774
GO:0035306
GO:0035509
GO:0036211
GO:0042326
GO:0042995
GO:0043226
GO:0043410
GO:0045616
GO:0045664
GO:0046872
GO:0048156
GO:0048598
GO:0048856
GO:0048870
GO:0050321
GO:0050900
GO:0050901
GO:0051045
GO:0051451
GO:0051492
GO:0051893
GO:0051894
GO:0061157
GO:0070168
GO:0070507
GO:0071559
GO:0072518
GO:0072659
GO:0090128
GO:0090521
GO:0097049
GO:0097746
GO:0098685
GO:0098772
GO:0106003
GO:0106310
GO:0110061
GO:0140058
GO:0140096
GO:1900223
GO:1900242
GO:1901888
GO:1902003
GO:1902430
GO:1902992
GO:1903140
GO:1903347
GO:1905205
GO:1990776
GO:2000114
GO:2000145
GO:2000672
HMNXSV003022657
Hs.150790.0.A1_3p_at
Hs.17820.1.A1_3p_at
Hs.17820.2.S2_3p_a_at
Hs2.376931.1.S1_3p_at
ILMN_1739583
ILMN_1808768
ILMN_1878375
PH_hs_0023646
TC18000397.hg
TC18000595.hg
TC18000859.hg
p7657
Participates
as an output of
Caspase-mediated cleavage of Rock-1 (Homo sapiens)
Other forms of this molecule
ROCK1 [extracellular region]
ROCK1 [secretory granule lumen]
Activated ROCK1 [cytosol]
ROCK1(1114-1354) [cytosol]
ROCK1 [cytosol]
Inferred To
ROCK1(1-1113) [cytosol]
(Bos taurus)
ROCK1(1-1113) [cytosol]
(Caenorhabditis elegans)
ROCK1(1-1113) [cytosol]
(Canis familiaris)
ROCK1(1-1113) [cytosol]
(Drosophila melanogaster)
ROCK1(1-1113) [cytosol]
(Gallus gallus)
ROCK1(1-1113) [cytosol]
(Mus musculus)
ROCK1(1-1113) [cytosol]
(Rattus norvegicus)
ROCK1(1-1113) [cytosol]
(Sus scrofa)
ROCK1(1-1113) [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_005397.1
ZINC - World Drugs
ROCK1_HUMAN
Guide to Pharmacology - Targets
1503
OpenTargets
ENSG00000067900
ZINC - FDA approved
ROCK1_HUMAN
ZINC - Substances
ROCK1_HUMAN
ZINC - Biogenic
ROCK1_HUMAN
ZINC target
Q13464
PRO
Q13464
PDB
5WNE
,
3NDM
,
5UZJ
,
4YVE
,
7JOU
,
1S1C
,
2ESM
,
5WNG
,
5WNH
,
3D9V
,
5WNF
,
4L2W
,
3TV7
,
5KKT
,
5HVU
,
2V55
,
5KKS
,
3TWJ
,
5F5P
,
3O0Z
,
3NCZ
,
2ETK
,
8P0S
,
7S26
,
5BML
,
4W7P
,
7S25
,
3V8S
,
6E9W
,
4YVC
,
2ETR
ZINC - Investigational
ROCK1_HUMAN
HPA
ENSG00000067900-ROCK1
GeneCards
Q13464
Ensembl
ENSG00000067900
,
ENSP00000382697
,
ENST00000399799
Pharos - Targets
Q13464
ZINC - Predictions - Purchasable
ROCK1_HUMAN
HMDB Protein
HMDBP01455
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O15481 MAGB4
0.742
6
UniProt:P61586 RHOA
6
RHOA [ficolin-1-rich granule membrane]
(R-HSA-6804971)
RHOA [secretory granule membrane]
(R-HSA-6804980)
RHOA [endoplasmic reticulum membrane]
(R-HSA-5672082)
RHOA [cytosol]
(R-HSA-194866)
RHOA [cell junction]
(R-HSA-2134503)
RHOA [plasma membrane]
(R-HSA-194510)
0.656
4
UniProt:Q86V42 F124A
0.556
3
UniProt:P25791 LMO2
1
LMO2 [nucleoplasm]
(R-HSA-8956513)
0.556
3
UniProt:Q9BUI4 POLR3C
2
POLR3C [cytosol]
(R-HSA-1964448)
POLR3C [nucleoplasm]
(R-HSA-1964430)
0.556
3
UniProt:Q8IYR0 CF206
0.556
3
UniProt:Q13203 MYBPH
0.544
2
UniProt:O75116 ROCK2
2
ROCK2 [cytosol]
(R-HSA-419058)
Activated ROCK2 [cytosol]
(R-HSA-4687775)
0.527
2
UniProt:Q7Z6J6 FRMD5
0.524
4
UniProt:Q99816 TSG101
1
TSG101 [endosome membrane]
(R-HSA-2980549)
0.508
4
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