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Dopamine Neurotransmitter Release Cycle
Stable Identifier
R-HSA-212676
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter release cycle (Homo sapiens)
Dopamine Neurotransmitter Release Cycle (Homo sapiens)
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Dopamine neurotransmitter cycle occurs in dopaminergic neurons. Dopamine is synthesized and loaded into the clathrin sculpted monoamine transport vesicles. The vesicles are docked, primed and fused with the plasmamembrane in the synapse to release dopamine into the synaptic cleft.
Literature References
PubMed ID
Title
Journal
Year
16613554
Targeting exocytosis: ins and outs of the modulation of quantal dopamine release
Westerink, RH
CNS Neurol Disord Drug Targets
2006
Participants
Events
Re-acidification of clathrin sculpted monoamine transport vesicle lumen
(Homo sapiens)
Loading of dopamine into synaptic veiscles
(Homo sapiens)
LIN7, CASK and APBA1 bind
(Homo sapiens)
Dopamine synaptic vesicle docking and priming
(Homo sapiens)
Release of docked dopamine loaded synaptic vesicle
(Homo sapiens)
Participates
as an event of
Neurotransmitter release cycle (Homo sapiens)
Event Information
Go Biological Process
neurotransmitter transport (0006836)
Orthologous Events
Dopamine Neurotransmitter Release Cycle (Bos taurus)
Dopamine Neurotransmitter Release Cycle (Caenorhabditis elegans)
Dopamine Neurotransmitter Release Cycle (Canis familiaris)
Dopamine Neurotransmitter Release Cycle (Drosophila melanogaster)
Dopamine Neurotransmitter Release Cycle (Gallus gallus)
Dopamine Neurotransmitter Release Cycle (Mus musculus)
Dopamine Neurotransmitter Release Cycle (Rattus norvegicus)
Dopamine Neurotransmitter Release Cycle (Schizosaccharomyces pombe)
Dopamine Neurotransmitter Release Cycle (Sus scrofa)
Dopamine Neurotransmitter Release Cycle (Xenopus tropicalis)
Authored
Mahajan, SS (2008-01-14)
Reviewed
Kavalali, E (2008-04-24)
Created
Mahajan, SS (2008-02-13)
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