Reactome | 3x4Hyp-COL2A1(182-1241) [extracellular region]

3x4Hyp-COL2A1(182-1241) [extracellular region]

Stable Identifier

R-HSA-2127413

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

3x4Hyp-COL2A1, 4-hydroxyprolyl collagen alpha-1(II) chain

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - NCAM signaling for neurite out-growth (Homo sapiens)
      - NCAM1 interactions (Homo sapiens)
        
        Interaction of NCAM1 with collagens (Homo sapiens)
        
        Collagens [extracellular region] (Homo sapiens)
        
        Collagen type II fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type II [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(II) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-COL2A1(182-1241) [extracellular region] (Homo sapiens)
        
        NCAM-1:Collagen complex [plasma membrane] (Homo sapiens)
        
        Collagens [extracellular region] (Homo sapiens)
        
        Collagen type II fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type II [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(II) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-COL2A1(182-1241) [extracellular region] (Homo sapiens)

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Homo sapiens)
    - OSCAR binds collagen and SP-D (Homo sapiens)
      - Collagen types I,II,III/SP-D [extracellular region] (Homo sapiens)
        
        Collagen types I,II,III [extracellular region] (Homo sapiens)
        
        Collagen type II fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type II [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(II) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-COL2A1(182-1241) [extracellular region] (Homo sapiens)
      - OSCAR:Collagen I,II,III/SP-D [extracellular region] (Homo sapiens)
        
        Collagen types I,II,III/SP-D [extracellular region] (Homo sapiens)
        
        Collagen types I,II,III [extracellular region] (Homo sapiens)
        
        Collagen type II fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type II [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(II) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-COL2A1(182-1241) [extracellular region] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by MET (Homo sapiens)
    - MET promotes cell motility (Homo sapiens)
      - MET activates PTK2 signaling (Homo sapiens)
        
        PTK2 binds activated MET (Homo sapiens)
        
        Integrin alpha2beta1,alpha3:beta1:(collagen,laminin,fibronectin) [plasma membrane] (Homo sapiens)
        
        Collagen, laminin, fibronectin [extracellular region] (Homo sapiens)
        
        Collagen fibres [extracellular region] (Homo sapiens)
        
        Collagen type II fibre [extracellular region] (Homo sapiens)
        
        Collagen type II fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type II [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(II) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-COL2A1(182-1241) [extracellular region] (Homo sapiens)
        
        Collagen type XI fibre [extracellular region] (Homo sapiens)
        
        Collagen type XI fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type XI [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(II) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-COL2A1(182-1241) [extracellular region] (Homo sapiens)
  - Signaling by PDGF (Homo sapiens)
    - PDGF binds to extracellular matrix proteins (Homo sapiens)
      - Extracellular matrix ligands [extracellular region] (Homo sapiens)
        
        Collagens [extracellular region] (Homo sapiens)
        
        Collagen type II fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type II [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(II) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-COL2A1(182-1241) [extracellular region] (Homo sapiens)
      - PDGF A and B chains:ECM complex [extracellular region] (Homo sapiens)
        
        Extracellular matrix ligands [extracellular region] (Homo sapiens)
        
        Collagens [extracellular region] (Homo sapiens)
        
        Collagen type II fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type II [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(II) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-COL2A1(182-1241) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P02458 COL2A1

Gene Names

COL2A1

Chain

signal peptide:1-25, propeptide:26-181, chain:182-1241, chain:1242-1487

Reference Genes

BioGPS Gene:1280 COL2A1

COSMIC (genes):COL2A1 COL2A1

CTD Gene:1280 COL2A1

dbSNP Gene:1280 COL2A1

ENSEMBL:ENSG00000139219 COL2A1

ENSEMBL:ENSG00000139219.19 COL2A1

HGNC:2200 COL2A1

KEGG Gene (Homo sapiens):1280 COL2A1

Monarch:1280 COL2A1

NCBI Gene:1280 COL2A1

OMIM:120140 COL2A1

UCSC:P02458 COL2A1

Reference Transcript

Other Identifiers

11757309_a_at

1280

16763783

213492_PM_at

213492_at

217404_PM_s_at

217404_s_at

3452864

3452866

3452867

3452868

3452870

3452872

3452873

3452874

3452875

3452876

3452878

3452879

3452881

3452882

3452883

3452884

3452886

3452887

3452888

3452889

3452890

3452891

3452892

3452894

3452895

3452896

3452897

3452898

3452899

3452900

3452902

3452903

3452904

3452905

3452907

3452908

3452909

3452910

3452911

3452912

3452913

3452914

3452916

3452918

3452919

3452921

3452925

3452926

3452927

3452928

3452929

3452930

3452931

3452932

3452933

3452934

3452935

3452937

3452940

3452941

37605_at

598_at

7962703

85915_at

A_23_P500464

GE57600

GO:0001501

GO:0001502

GO:0001503

GO:0001894

GO:0001958

GO:0002062

GO:0003007

GO:0005198

GO:0005201

GO:0005515

GO:0005576

GO:0005581

GO:0005585

GO:0005592

GO:0005604

GO:0005615

GO:0005737

GO:0005783

GO:0005788

GO:0006029

GO:0007417

GO:0007601

GO:0007605

GO:0010468

GO:0012501

GO:0023052

GO:0030020

GO:0030154

GO:0030198

GO:0030199

GO:0030312

GO:0030903

GO:0031012

GO:0035108

GO:0042289

GO:0042472

GO:0042802

GO:0042803

GO:0043226

GO:0043394

GO:0046872

GO:0048407

GO:0048705

GO:0048839

GO:0048856

GO:0050877

GO:0051216

GO:0060021

GO:0060174

GO:0060272

GO:0060348

GO:0060351

GO:0062023

GO:0071599

GO:0071773

GO:0097065

GO:0097192

GO:1901135

GO:2001240

HMNXSV003048858

Hs.81343.0.S2_3p_at

Hs.81343.1.S1_3p_a_at

ILMN_1674785

ILMN_1742840

J00116_s_at

M60299_at

PH_hs_0024730

TC12001440.hg

X06268_at

Participates

as a member of

Collagen alpha-1(II) chains [extracellular region] (Homo sapiens)

Other forms of this molecule

GalHyl-COL2A1(26-1487) [endoplasmic reticulum lumen]

3x4Hyp-GalHyl-COL2A1(26-1487) [endoplasmic reticulum lumen]

3x4Hyp-3Hyp-GalHyl-COL2A1(26-1487) [endoplasmic reticulum lumen]

GlcGalHyl-COL2A1(26-1487) [endoplasmic reticulum lumen]

3x4Hyp-3Hyp-GlcGalHyl-COL2A1(26-1487) [endoplasmic reticulum lumen]

3x4Hyp-GlcGalHyl-COL2A1(26-1487) [endoplasmic reticulum lumen]

COL2A1(26-1487) [endoplasmic reticulum lumen]

3x4Hyp-COL2A1(26-1487) [endoplasmic reticulum lumen]

3x4Hyp-3Hyp-COL2A1(26-1487) [endoplasmic reticulum lumen]

3x4Hyp-5Hyl-COL2A1(26-1487) [endoplasmic reticulum lumen]

3x4Hyp-3Hyp-5Hyl-COL2A1(26-1487) [endoplasmic reticulum lumen]

5Hyl-COL2A1(26-1487) [endoplasmic reticulum lumen]

GalHyl-COL2A1(26-1487) [extracellular region]

3x4Hyp-3Hyp-COL2A1(26-1487) [extracellular region]

COL2A1(26-1487) [extracellular region]

3x4Hyp-5Hyl-COL2A1(26-1487) [extracellular region]

GlcGalHyl-COL2A1(26-1487) [extracellular region]

3x4Hyp-COL2A1(26-1487) [extracellular region]

3x4Hyp-GlcGalHyl-COL2A1(26-1487) [extracellular region]

5Hyl-COL2A1(26-1487) [extracellular region]

3x4Hyp-3Hyp-GlcGalHyl-COL2A1(26-1487) [extracellular region]

3x4Hyp-3Hyp-5Hyl-COL2A1(26-1487) [extracellular region]

3x4Hyp-GalHyl-COL2A1(26-1487) [extracellular region]

5Hyl-COL2A1(182-1487) [extracellular region]

GalHyl-COL2A1(182-1487) [extracellular region]

COL2A1(182-1487) [extracellular region]

GlcGalHyl-COL2A1(182-1487) [extracellular region]

3x4Hyp-3Hyp-COL2A1(182-1487) [extracellular region]

3x4Hyp-3Hyp-5Hyl-COL2A1(182-1487) [extracellular region]

3x4Hyp-COL2A1(182-1487) [extracellular region]

3x4Hyp-GalHyl-COL2A1(182-1487) [extracellular region]

3x4Hyp-3Hyp-GalHyl-COL2A1(26-1487) [extracellular region]

3x4Hyp-3Hyp-GlcGalHyl-COL2A1(182-1487) [extracellular region]

3x4Hyp-GlcGalHyl-COL2A1(182-1487) [extracellular region]

3x4Hyp-5Hyl-COL2A1(182-1487) [extracellular region]

GalHyl-COL2A1(976-1241) [extracellular region]

GalHyl-COL2A1(182-975) [extracellular region]

5Hyl-COL2A1(182-975) [extracellular region]

3x4Hyp-COL2A1(182-975) [extracellular region]

COL2A1(182-975) [extracellular region]

3x4Hyp-GlcGalHyl-COL2A1(976-1241) [extracellular region]

3x4Hyp-3Hyp-GalHyl-COL2A1(976-1241) [extracellular region]

GlcGalHyl-COL2A1(182-975) [extracellular region]

3x4Hyp-GalHyl-COL2A1(976-1241) [extracellular region]

3x4Hyp-3Hyp-5Hyl-COL2A1(182-975) [extracellular region]

3x4Hyp-3Hyp-COL2A1(182-975) [extracellular region]

3x4Hyp-GalHyl-COL2A1(182-975) [extracellular region]

3x4Hyp-3Hyp-COL2A1(976-1241) [extracellular region]

3x4Hyp-3Hyp-GlcGalHyl-COL2A1(976-1241) [extracellular region]

3x4Hyp-5Hyl-COL2A1(182-975) [extracellular region]

3x4Hyp-3Hyp-GlcGalHyl-COL2A1(182-975) [extracellular region]

GlcGalHyl-COL2A1(976-1241) [extracellular region]

3x4Hyp-COL2A1(976-1241) [extracellular region]

3x4Hyp-3Hyp-5Hyl-COL2A1(976-1241) [extracellular region]

3x4Hyp-3Hyp-GalHyl-COL2A1(182-975) [extracellular region]

COL2A1(976-1241) [extracellular region]

3x4Hyp-GlcGalHyl-COL2A1(182-975) [extracellular region]

3x4Hyp-5Hyl-COL2A1(976-1241) [extracellular region]

5Hyl-COL2A1(976-1241) [extracellular region]

COL2A1(182-1241) [extracellular region]

3x4Hyp-GalHyl-COL2A1(182-1241) [extracellular region]

GalHyl-COL2A1(182-1241) [extracellular region]

3x4Hyp-3Hyp-GlcGalHyl-COL2A1(182-1241) [extracellular region]

3x4Hyp-GlcGalHyl-COL2A1(182-1241) [extracellular region]

5Hyl-COL2A1(182-1241) [extracellular region]

3x4Hyp-3Hyp-5Hyl-COL2A1(182-1241) [extracellular region]

3x4Hyp-3Hyp-COL2A1(182-1241) [extracellular region]

3x4Hyp-5Hyl-COL2A1(182-1241) [extracellular region]

GlcGalHyl-COL2A1(182-1241) [extracellular region]

3x4Hyp-3Hyp-GalHyl-COL2A1(182-1241) [extracellular region]

Inferred To

COL2A1 [extracellular region] (Sus scrofa)

LOC100488932 [extracellular region] (Xenopus tropicalis)

3x4Hyp-COL2A1(182-1241) [extracellular region] (Bos taurus)

3x4Hyp-COL2A1(182-1241) [extracellular region] (Canis familiaris)

3x4Hyp-COL2A1(182-1241) [extracellular region] (Gallus gallus)

3x4Hyp-COL2A1(182-1241) [extracellular region] (Mus musculus)

3x4Hyp-COL2A1(182-1241) [extracellular region] (Rattus norvegicus)

col2a1 [extracellular region] (Danio rerio)

Modified Residues

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Cross References

RefSeq

NP_001835.3, NP_149162.2

OpenTargets

ENSG00000139219

HPA

ENSG00000139219-COL2A1

GeneCards

P02458

Ensembl

ENSP00000369889, ENSG00000139219, ENST00000380518, ENSP00000338213, ENST00000337299

PRO

P02458

Pharos - Targets

P02458

Orphanet

15769

PDB

6NIX, 2SEB, 1U5M, 2FSE, 5OCX, 6BIN, 7NZE, 5NIR, 5OCY, 6HG7

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