Reactome | CD74 [clathrin-coated endocytic vesicle membrane]

CD74 [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-HSA-2130522

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

Invariant chain (Ii), HLA class II histocompatibility antigen gamma chain, HG2A_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P04233 CD74

Gene Names

CD74, DHLAG

Chain

chain:1-296, peptide:97-120

Reference Genes

BioGPS Gene:972 CD74

COSMIC (genes):CD74 CD74

CTD Gene:972 CD74

dbSNP Gene:972 CD74

ENSEMBL:ENSG00000019582 CD74

HGNC:1697 CD74

KEGG:hsa:972 CD74

Monarch:972 CD74

NCBI Gene:972 CD74

OMIM:142790 CD74

UCSC:P04233 CD74

Reference Transcript

Participates

as a component of

Invariant chain trimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Other forms of this molecule

CD74 [plasma membrane]

CD74 [lysosomal membrane]

CD74(1-176) [lysosomal membrane]

CD74 [endocytic vesicle membrane]

CD74 [transport vesicle membrane]

CD74 [trans-Golgi network membrane]

CD74 [Golgi membrane]

CD74 [ER to Golgi transport vesicle membrane]

CD74 [lumenal side of endoplasmic reticulum membrane]

CD74(1-117) [lysosomal membrane]

CD74(81-104) [lysosomal membrane]

CD74(81-104) [lysosomal lumen]

Inferred To

Cd74 [clathrin-coated endocytic vesicle membrane] (Mus musculus)

Cd74 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)

Ii [clathrin-coated endocytic vesicle membrane] (Gallus gallus)

CD74 [clathrin-coated endocytic vesicle membrane] (Bos taurus)

CD74 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)

CD74 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)

Ghost homologue of CD74 [clathrin-coated endocytic vesicle membrane] (Xenopus tropicalis)

cd74a [clathrin-coated endocytic vesicle membrane] (Danio rerio)

Cross References

Guide to Pharmacology - Targets

2840

ENSEMBL

ENST00000377795, ENSP00000367026, ENSP00000009530, ENST00000009530, ENSP00000230685, ENSG00000019582, ENST00000353334

OpenTargets

ENSG00000019582

HPA

ENSG00000019582-CD74

GeneCards

CD74

ZINC - Substances

HG2A_HUMAN

ZINC target

P04233

PRO

P04233

Pharos - Targets

P04233

GlyGen

P04233

ZINC - Predictions - Purchasable

HG2A_HUMAN

PDB

1A6A, 3PDO, 4AEN, 9CYL, 5KSV, 8VSP, 9CYM, 1IIE, 3PGC, 1MUJ, 1L3H, 3PGD, 7Z0Q, 3QXA, 4X5W, 3QXD, 1ICF, 4AH2, 5KSU, 7YXB, 8VSJ, 8VRW, 7YX9

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01909 HLA-DQA1	9	HLA class II histocompatibility antigen, DQ [plasma membrane] (R-HSA-197585) HLA class II histocompatibility antigen, DQ [lysosomal membrane] (R-HSA-2130686) HLA class II histocompatibility antigen, DQ [endocytic vesicle membrane] (R-HSA-2130529) HLA class II histocompatibility antigen, DQ [clathrin-coated endocytic vesicle membrane] (R-HSA-2130595) HLA class II histocompatibility antigen, DQ [transport vesicle membrane] (R-HSA-2130733) HLA class II histocompatibility antigen, DQ [trans-Golgi network membrane] (R-HSA-2130568) HLA class II histocompatibility antigen, DQ [Golgi membrane] (R-HSA-2214382) HLA class II histocompatibility antigen, DQ [ER to Golgi transport vesicle membrane] (R-HSA-2130699) HLA class II histocompatibility antigen, DQ [lumenal side of endoplasmic reticulum membrane] (R-HSA-2130716)	0.674	4
UniProt:P01903 HLA-DRA	9	HLA class II histocompatibility antigen, DR alpha chain precursor [plasma membrane] (R-HSA-197588) HLA class II histocompatibility antigen, DR alpha chain precursor [lysosomal membrane] (R-HSA-2130677) HLA class II histocompatibility antigen, DR alpha chain precursor [endocytic vesicle membrane] (R-HSA-2130463) HLA class II histocompatibility antigen, DR alpha chain precursor [clathrin-coated endocytic vesicle membrane] (R-HSA-2130442) HLA class II histocompatibility antigen, DR alpha chain precursor [transport vesicle membrane] (R-HSA-2130530) HLA class II histocompatibility antigen, DR alpha chain precursor [trans-Golgi network membrane] (R-HSA-2130586) HLA class II histocompatibility antigen, DR alpha chain precursor [Golgi membrane] (R-HSA-2214390) HLA class II histocompatibility antigen, DR alpha chain precursor [ER to Golgi transport vesicle membrane] (R-HSA-2130480) HLA class II histocompatibility antigen, DR alpha chain precursor [lumenal side of endoplasmic reticulum membrane] (R-HSA-2130665)	0.564	2
UniProt:P61073 CXCR4	1	CXCR4 [plasma membrane] (R-HSA-2980772)	0.556	4
UniProt:P40939 HADHA	1	HADHA [mitochondrial inner membrane] (R-HSA-77264)	0.547	2
UniProt:hspa1a_hspa1b_human-1 EBI-11820565			0.544	3
UniProt:P0A6Y8 DNAK			0.544	8
UniProt:Q9UBF2 COPG2	4	COPG2 [endoplasmic reticulum membrane] (R-HSA-6810962) COPG2 [Golgi membrane] (R-HSA-6808751) COPG2 [transport vesicle] (R-HSA-6808753) COPG2 [cytosol] (R-HSA-6807747)	0.527	2
UniProt:Q9Y678 COPG1	4	COPG1 [endoplasmic reticulum membrane] (R-HSA-6810960) COPG1 [Golgi membrane] (R-HSA-6808747) COPG1 [transport vesicle] (R-HSA-6808749) COPG1 [cytosol] (R-HSA-199987)	0.527	2
UniProt:P04440 HLA-DPB1	9	HLA class II histocompatibility antigen, DP [plasma membrane] (R-HSA-197648) HLA class II histocompatibility antigen, DP [lysosomal membrane] (R-HSA-2130601) HLA class II histocompatibility antigen, DP [endocytic vesicle membrane] (R-HSA-2130419) HLA class II histocompatibility antigen, DP [clathrin-coated endocytic vesicle membrane] (R-HSA-2130390) HLA class II histocompatibility antigen, DP [transport vesicle membrane] (R-HSA-2130533) HLA class II histocompatibility antigen, DP [trans-Golgi network membrane] (R-HSA-2130397) HLA class II histocompatibility antigen, DP [Golgi membrane] (R-HSA-2214364) HLA class II histocompatibility antigen, DP [ER to Golgi transport vesicle membrane] (R-HSA-2130688) HLA class II histocompatibility antigen, DP [lumenal side of endoplasmic reticulum membrane] (R-HSA-2130709)	0.527	2
UniProt:O00264 PGRMC1	2	PGRMC1 [plasma membrane] (R-HSA-6806314) PGRMC1 [specific granule membrane] (R-HSA-6799648)	0.527	2
UniProt:P25025 CXCR2	2	CXCR2 [plasma membrane] (R-HSA-373796) CXCR2 [secretory granule membrane] (R-HSA-6804771)	0.524	2
UniProt:Q14974 KPNB1	5	KPNB1 [cytosol] (R-HSA-180733) KPNB1 [nucleoplasm] (R-HSA-180714) KPNB1 [ficolin-1-rich granule lumen] (R-HSA-6800978) KPNB1 [extracellular region] (R-HSA-6806306) KPNB1 [specific granule lumen] (R-HSA-6799646)	0.499	2
UniProt:P60228 EIF3E	1	EIF3E [cytosol] (R-HSA-72552)	0.499	2
UniProt:P16070 CD44	2	CD44 [plasma membrane] (R-HSA-1031688) CD44 [secretory granule membrane] (R-HSA-6804776)	0.463	9

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