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SH3GL2 [clathrin-coated endocytic vesicle membrane]
Stable Identifier
R-HSA-2130629
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
clathrin-coated endocytic vesicle membrane
Synonyms
Endophilin
Locations in the PathwayBrowser for interactor UniProt:Q99961 SH3GL1
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
MHC class II antigen presentation (Homo sapiens)
Uncoating of clathrin-coated vesicles and fusion with endosomes (Homo sapiens)
SH3GL2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99962 SH3GL2
Gene Names
SH3GL2, CNSA2, SH3D2A
Chain
chain:1-352
Reference Genes
BioGPS Gene:6456 SH3GL2
COSMIC (genes):SH3GL2 SH3GL2
CTD Gene:6456 SH3GL2
dbSNP Gene:6456 SH3GL2
ENSEMBL:ENSG00000107295 SH3GL2
ENSEMBL_homo_sapiens_GENE:ENSG00000107295.10 SH3GL2
HGNC:10831 SH3GL2
KEGG Gene (Homo sapiens):6456 SH3GL2
Monarch:6456 SH3GL2
NCBI Gene:6456 SH3GL2
OMIM:604465 SH3GL2
UCSC:Q99962 SH3GL2
Reference Transcript
RefSeq:NM_003026.3 SH3GL2
Other Identifiers
11730182_a_at
11730183_s_at
17083776
205751_PM_at
205751_at
3163827
3163828
3163829
3163830
3163831
3163860
3163861
3163863
3163866
3163868
3163869
3163870
3163871
3163872
3163873
3163874
3163875
40378_at
6456
8154476
A_14_P101372
A_23_P169351
GE54291
GO:0000139
GO:0001933
GO:0003013
GO:0005515
GO:0005737
GO:0005768
GO:0005769
GO:0005794
GO:0005829
GO:0005886
GO:0006897
GO:0007165
GO:0007417
GO:0008289
GO:0010629
GO:0016020
GO:0016191
GO:0016192
GO:0023052
GO:0030154
GO:0030669
GO:0031175
GO:0031410
GO:0036211
GO:0042802
GO:0042995
GO:0043226
GO:0045202
GO:0048471
GO:0048856
GO:0097484
GO:0098793
GO:0098978
GO:1905604
GO:1990416
HMNXSV003007293
ILMN_1661491
TC09000085.hg
X99657_at
g4506930_3p_at
Participates
as an output of
Uncoating of clathrin-coated vesicles and fusion with endosomes (Homo sapiens)
as a component of
Clathrin coated MHC class II alpha/beta/Ii nonamer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Other forms of this molecule
SH3GL2 [cytosol]
SH3GL2 [plasma membrane]
SH3GL2 [Golgi membrane]
Inferred To
sh3gl2a [clathrin-coated endocytic vesicle membrane]
(Danio rerio)
Sh3gl2 [clathrin-coated endocytic vesicle membrane]
(Mus musculus)
Sh3gl2 [clathrin-coated endocytic vesicle membrane]
(Rattus norvegicus)
sh3gl2 [clathrin-coated endocytic vesicle membrane]
(Xenopus tropicalis)
SH3GL2 [clathrin-coated endocytic vesicle membrane]
(Bos taurus)
SH3GL2 [clathrin-coated endocytic vesicle membrane]
(Canis familiaris)
SH3GL2 [clathrin-coated endocytic vesicle membrane]
(Gallus gallus)
SH3GL2 [clathrin-coated endocytic vesicle membrane]
(Sus scrofa)
Cross References
RefSeq
NP_003017.1
OpenTargets
ENSG00000107295
HPA
ENSG00000107295-SH3GL2
GeneCards
Q99962
Ensembl
ENSG00000107295
,
ENSP00000369981
,
ENST00000380607
PRO
Q99962
Pharos - Targets
Q99962
PDB
2D4C
,
1X04
,
2DBM
,
1X03
Interactors (21)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q99961 SH3GL1
1
SH3GL1 [cytosol]
(R-HSA-8867732)
0.804
7
UniProt:Q96B97 SH3KBP1
3
SH3KBP1 [plasma membrane]
(R-HSA-182955)
SH3KBP1 [cytosol]
(R-HSA-182957)
Ub-SH3KBP1 [cytosol]
(R-HSA-182926)
0.788
5
UniProt:Q99700 ATX2
0.779
9
UniProt:Q99962 SH3GL2
4
SH3GL2 [cytosol]
(R-HSA-182958)
SH3GL2 [plasma membrane]
(R-HSA-177495)
SH3GL2 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130629)
SH3GL2 [Golgi membrane]
(R-HSA-351189)
0.744
4
UniProt:P50570 DNM2
5
DNM2 [Golgi membrane]
(R-HSA-2980842)
DNM2 [endocytic vesicle membrane]
(R-HSA-2029000)
DNM2 [cytosol]
(R-HSA-2213180)
DNM2 [lysosomal membrane]
(R-HSA-2980840)
DNM2 [plasma membrane]
(R-HSA-2984201)
0.722
4
UniProt:Q99963 SH3GL3
1
SH3GL3 [cytosol]
(R-HSA-8867734)
0.721
7
UniProt:Q70E73 RAPH1
0.72
5
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.681
4
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.623
4
UniProt:Q924I2 M4K3
0.611
3
UniProt:Q6ICL3 TNG2
0.589
2
UniProt:Q62910
1
Synj1 [cytosol]
(R-RNO-1604634)
0.573
2
UniProt:O43426 SYNJ1
1
SYNJ1 [cytosol]
(R-HSA-1604634)
0.558
2
UniProt:Q8IUX8 EGFL6
0.553
2
UniProt:P20160 AZU1
2
AZU1 [extracellular region]
(R-HSA-6806193)
AZU1 [azurophil granule lumen]
(R-HSA-6798767)
0.527
2
UniProt:Q96J02 ITCH
2
Ub-C871-ITCH [cytosol]
(R-HSA-8864515)
ITCH [cytosol]
(R-HSA-975995)
0.526
3
UniProt:Q9H3S7 PTPN23
1
PTPN23 [nucleoplasm]
(R-HSA-9008924)
0.508
2
UniProt:P50402 EMD
4
EMD [nuclear envelope]
(R-HSA-201573)
EMD [cytosol]
(R-HSA-9613988)
EMD [endoplasmic reticulum membrane]
(R-HSA-9613998)
EMD [endosome membrane]
(R-HSA-9715092)
0.508
2
UniProt:Q13443 ADAM9
1
ADAM9 [plasma membrane]
(R-HSA-708336)
0.508
2
UniProt:Q13444 ADAM15
1
ADAM15 [plasma membrane]
(R-HSA-708329)
0.508
2
UniProt:P22681 CBL
20
PolyUb,p-Y-CBL [cytosol]
(R-HSA-9763893)
CBL R420G [cytosol]
(R-HSA-9706203)
CBL R420Q [cytosol]
(R-HSA-9706186)
CBL Y371H [cytosol]
(R-HSA-9706680)
CBL H398Y [cytosol]
(R-HSA-9706639)
CBL P417A [cytosol]
(R-HSA-9706636)
CBL S376F [cytosol]
(R-HSA-9706643)
CBL E366_Q409del [cytosol]
(R-HSA-9706179)
CBL del366-477 [cytosol]
(R-HSA-9706176)
CBL R499L [cytosol]
(R-HSA-9706678)
CBL L380P [cytosol]
(R-HSA-9706630)
CBL L287R [cytosol]
(R-HSA-9706693)
CBL L380R [cytosol]
(R-HSA-9706635)
CBL G375P [cytosol]
(R-HSA-9706219)
CBL P417L [cytosol]
(R-HSA-9706634)
CBL H398Q [cytosol]
(R-HSA-9706633)
CBL P417R [cytosol]
(R-HSA-9706632)
CBL R499* [cytosol]
(R-HSA-9706670)
CBL H398R [cytosol]
(R-HSA-9706638)
CBL H398P [cytosol]
(R-HSA-9706637)
0.499
2
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