Reactome | Translocation of TGN-lysosome vesicle to lysosome

Translocation of TGN-lysosome vesicle to lysosome

Stable Identifier

R-HSA-2130641

Type

Reaction [transition]

Species

Homo sapiens

Compartment

trans-Golgi network membrane, cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Translocation of TGN-lysosome vesicle to lysosome

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Budding vesicles loaded with the nonameric complex bud off from the TGN to reach the late-endosome/lysosome membrane.

Literature References

PubMed ID	Title	Journal	Year
7650016	A role for acidic residues in di-leucine motif-based targeting to the endocytic pathway Peterson, PA, Tainer, JA, Pond, L, Schutze, MP, Jackson, MR, Teyton, L, Kuhn, LA	J Biol Chem	1995
10480952	Direct transport of newly synthesized HLA-DR from the trans-Golgi network to major histocompatibility complex class II containing compartments (MIICS) demonstrated using a novel tyrosine-sulfated chimera Davidson, HW	J Biol Chem	1999
8939989	Expression of major histocompatibility complex class II molecules in HeLa cells promotes the recruitment of AP-1 Golgi-specific assembly proteins on Golgi membranes Goud, B, Hoflack, B, Salamero, J, Le Borgne, R, Saudrais, C	J Biol Chem	1996
7592972	Structure-activity relationship of the leucine-based sorting motifs in the cytosolic tail of the major histocompatibility complex-associated invariant chain Morelli, MA, Frank, RW, Saviano, G, Bremnes, B, Motta, A, Bakke, O	J Biol Chem	1995
9497313	Medium chains of adaptor complexes AP-1 and AP-2 recognize leucine-based sorting signals from the invariant chain Rodionov, DG, Bakke, O	J Biol Chem	1998
10593899	The leucine-based sorting motifs in the cytoplasmic domain of the invariant chain are recognized by the clathrin adaptors AP1 and AP2 and their medium chains Dobberstein, B, Rodionov, D, von Figura, K, Höning, S, Bakke, O, Hofmann, MW	J Biol Chem	1999
2121367	MHC class II-associated invariant chain contains a sorting signal for endosomal compartments Dobberstein, B, Bakke, O	Cell	1990