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HLA class II histocompatibility antigen, DQ [lysosomal membrane]
Stable Identifier
R-HSA-2130686
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
lysosomal membrane
Synonyms
HA23_HUMAN, HLA-DQA1
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
MHC class II antigen presentation (Homo sapiens)
Cleavage of lip22 to lip10 (Homo sapiens)
MHC II:lip10 nonamer [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II alpha chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DQ [lysosomal membrane] (Homo sapiens)
MHC II:lip22 nonamer [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II alpha chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DQ [lysosomal membrane] (Homo sapiens)
Disassociation of CLIP from MHC II (Homo sapiens)
MHC II:CLIP [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II alpha chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DQ [lysosomal membrane] (Homo sapiens)
peptide free MHC II:HLA-DM [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II alpha chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DQ [lysosomal membrane] (Homo sapiens)
Generation of CLIP from lip10 (Homo sapiens)
MHC II:CLIP [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II alpha chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DQ [lysosomal membrane] (Homo sapiens)
MHC II:lip10 nonamer [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II alpha chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DQ [lysosomal membrane] (Homo sapiens)
Initial proteolyis of Ii by aspartic proteases to lip22 (Homo sapiens)
MHC II:lip22 nonamer [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II alpha chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DQ [lysosomal membrane] (Homo sapiens)
Nonameric complex [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II alpha chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DQ [lysosomal membrane] (Homo sapiens)
Loading of antigenic peptides (Homo sapiens)
peptide free MHC II:HLA-DM [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II alpha chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DQ [lysosomal membrane] (Homo sapiens)
peptide loaded MHC class II [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II alpha chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DQ [lysosomal membrane] (Homo sapiens)
TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome (Homo sapiens)
Nonameric complex [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II alpha chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DQ [lysosomal membrane] (Homo sapiens)
Trafficking of nonameric complex in the endocytic pathway (Homo sapiens)
Nonameric complex [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II alpha chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DQ [lysosomal membrane] (Homo sapiens)
Transport of antigen loaded MHC II molecules to surface (Homo sapiens)
peptide loaded MHC class II [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II alpha chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DQ [lysosomal membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01909 HLA-DQA1
Gene Names
HLA-DQA1
Chain
signal peptide:1-23, chain:24-254
Reference Genes
BioGPS Gene:3117 HLA-DQA1
COSMIC (genes):HLA-DQA1 HLA-DQA1
CTD Gene:3117 HLA-DQA1
dbSNP Gene:3117 HLA-DQA1
ENSEMBL:ENSG00000196735 HLA-DQA1
ENSEMBL:ENSG00000206305 HLA-DQA1
ENSEMBL:ENSG00000232062 HLA-DQA1
HGNC:4942 HLA-DQA1
KEGG Gene (Homo sapiens):3117 HLA-DQA1
Monarch:3117 HLA-DQA1
NCBI Gene:3117 HLA-DQA1
OMIM:146880 HLA-DQA1
UCSC:P01909 HLA-DQA1
Reference Transcript
RefSeq:NM_002122.3 HLA-DQA1
Other Identifiers
0006220735
0006550605
11724799_x_at
11750528_x_at
11753898_x_at
11756083_x_at
11758340_x_at
17028326
17038609
17041240
203290_at
212671_s_at
213831_at
2903223
2903224
2903227
2903229
2903231
2903233
2903234
2903235
2903236
2903259
2903265
2903266
3117
32773_at
8118556
8178199
8179489
A_23_P30900
A_24_P196827
A_24_P326084
A_24_P393230
A_33_P3293049
GE81121
GE890404
GO:0000139
GO:0002250
GO:0002376
GO:0002504
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005764
GO:0005765
GO:0005768
GO:0005773
GO:0005783
GO:0005789
GO:0005794
GO:0005886
GO:0005887
GO:0006950
GO:0006955
GO:0007165
GO:0008150
GO:0010008
GO:0012507
GO:0016020
GO:0016021
GO:0019882
GO:0019886
GO:0030658
GO:0030666
GO:0030669
GO:0031410
GO:0032395
GO:0032588
GO:0032991
GO:0042605
GO:0042613
GO:0043226
GO:0050852
GO:0060333
GO:0071556
HMNXSV003000947
HMNXSV003054155
HMNXSV003055601
HMNXSV003056103
Hs.198253.1.A1_3p_a_at
Hs.198253.2.A1_3p_s_at
ILMN_1808405
ILMN_3249667
K01160_s_at
M26041_s_at
M34996_s_at
PH_hs_0033085
TC06000400.hg
TC6_cox_hap2000091.hg
TC6_qbl_hap6000082.hg
TC6_ssto_hap7000077.hg
g4504406_3p_at
Participates
as a member of
HLA II alpha chain [lysosomal membrane] (Homo sapiens)
Other forms of this molecule
HLA class II histocompatibility antigen, DQ [integral component of lumenal side of endoplasmic reticulum membrane]
HLA class II histocompatibility antigen, DQ [ER to Golgi transport vesicle membrane]
HLA class II histocompatibility antigen, DQ [Golgi membrane]
HLA class II histocompatibility antigen, DQ [trans-Golgi network membrane]
HLA class II histocompatibility antigen, DQ [transport vesicle membrane]
HLA class II histocompatibility antigen, DQ [clathrin-coated endocytic vesicle membrane]
HLA class II histocompatibility antigen, DQ [endocytic vesicle membrane]
HLA class II histocompatibility antigen, DQ [plasma membrane]
Inferred To
mhc2d8.37a1 [lysosomal membrane]
(Danio rerio)
BOLA-DQA1 [lysosomal membrane]
(Bos taurus)
si:busm1-194e12.8 [lysosomal membrane]
(Danio rerio)
Homologues of HLA class II histocompatibility antigen, DQ [lysosomal membrane]
(Danio rerio)
Homologues of HLA class II histocompatibility antigen, DQ [lysosomal membrane]
(Xenopus tropicalis)
hla-dqa1 [lysosomal membrane]
(Xenopus tropicalis)
HLA class II histocompatibility antigen, DQ [lysosomal membrane]
(Danio rerio)
HLA class II histocompatibility antigen, DQ [lysosomal membrane]
(Xenopus tropicalis)
H2-Aa [lysosomal membrane]
(Mus musculus)
SLA-DQA1 [lysosomal membrane]
(Sus scrofa)
DLA-DQA1 [lysosomal membrane]
(Canis familiaris)
mhc2d8.46a [lysosomal membrane]
(Danio rerio)
si:dkey-33b17.1 [lysosomal membrane]
(Danio rerio)
RT1-Ba [lysosomal membrane]
(Rattus norvegicus)
mhc2d8.37a2 [lysosomal membrane]
(Danio rerio)
Cross References
RefSeq
NP_002113.2
OpenTargets
ENSG00000196735
HPA
ENSG00000196735-HLA-DQA1
GeneCards
P01909
Ensembl
ENSG00000206305
,
ENST00000395363
,
ENSP00000378767
,
ENSG00000196735
,
ENSP00000413237
,
ENSG00000232062
,
ENST00000383251
,
ENSP00000382586
,
ENST00000374949
,
ENST00000418023
,
ENSP00000382583
,
ENST00000399675
,
ENSP00000339398
,
ENST00000399678
,
ENSP00000364087
,
ENST00000444296
,
ENSP00000387892
,
ENST00000343139
,
ENSP00000372738
PRO
P01909
Pharos - Targets
P01909
GlyGen
P01909
Orphanet
16829
PDB
6U3N
,
1JK8
,
1UVQ
,
6U3M
,
4GG6
,
5KSU
,
4OZG
,
4OZF
,
2NNA
,
6MFG
,
5KSB
,
4OZI
,
4OZH
,
1S9V
,
5KSA
,
6MFF
,
5KSV
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04233 CD74
13
CD74(81-104) [lysosomal lumen]
(R-HSA-2213220)
CD74(81-104) [lysosomal membrane]
(R-HSA-2130446)
CD74(1-117) [lysosomal membrane]
(R-HSA-2130632)
CD74 [integral component of lumenal side of endoplasmic reticulum membrane]
(R-HSA-1181241)
CD74 [ER to Golgi transport vesicle membrane]
(R-HSA-2130456)
CD74 [Golgi membrane]
(R-HSA-2214388)
CD74 [trans-Golgi network membrane]
(R-HSA-2130493)
CD74 [transport vesicle membrane]
(R-HSA-2130624)
CD74 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130522)
CD74 [endocytic vesicle membrane]
(R-HSA-2130460)
CD74(1-176) [lysosomal membrane]
(R-HSA-2130602)
CD74 [lysosomal membrane]
(R-HSA-2130320)
CD74 [plasma membrane]
(R-HSA-2130666)
0.536
2
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