Reactome | AP2S1 [clathrin-coated endocytic vesicle membrane]

AP2S1 [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-HSA-2130707

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

AP-2 complex subunit sigma, Adaptor protein complex AP-2 subunit sigma, Plasma membrane adapto AP-2 17 kDa protein

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by WNT (Homo sapiens)
  - Beta-catenin independent WNT signaling (Homo sapiens)
    - PCP/CE pathway (Homo sapiens)
      - WNT5A-dependent internalization of FZD4 (Homo sapiens)
        
        WNT5A:FZD4 is endocytosed (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2:AP-2:clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        clathrin:AP-2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 Complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP2S1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P53680 AP2S1

Gene Names

AP2S1, AP17, CLAPS2

Chain

chain:1-142

Reference Genes

BioGPS Gene:1175 AP2S1

COSMIC (genes):AP2S1 AP2S1

CTD Gene:1175 AP2S1

dbSNP Gene:1175 AP2S1

ENSEMBL:ENSG00000042753 AP2S1

HGNC:565 AP2S1

KEGG:hsa:1175 AP2S1

Monarch:1175 AP2S1

NCBI Gene:1175 AP2S1

OMIM:602242 AP2S1

UCSC:P53680 AP2S1

Reference Transcript

Participates

as a component of

AP-2 Complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Other forms of this molecule

AP2S1 [plasma membrane]

AP2S1 [cytosol]

AP2S1 [endolysosome membrane]

Inferred To

AP-2sigma [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)

ap2s1 [clathrin-coated endocytic vesicle membrane] (Xenopus tropicalis)

AP2S1 [clathrin-coated endocytic vesicle membrane] (Bos taurus)

AP2S1 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)

AP2S1 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)

aps-2 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)

Ap2s1 [clathrin-coated endocytic vesicle membrane] (Mus musculus)

Ap2s1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_067586.1, NP_001288005.1, NP_004060.2, NP_001288007.1, NP_001288010.1

OpenTargets

ENSG00000042753

ENSEMBL

ENSP00000263270, ENST00000263270, ENSG00000042753, ENSP00000470898, ENST00000601649

HPA

ENSG00000042753-AP2S1

GeneCards

AP2S1

PRO

P53680

Pharos - Targets

P53680

Orphanet

AP2S1

GlyGen

P53680

PDB

6URI

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42566 EPS15	2	EPS15 [cytosol] (R-HSA-182920) p-Y849 EPS15 [cytosol] (R-HSA-8867028)	0.788	7
UniProt:Q2M2I8 AAK1	1	AAK1 [cytosol] (R-HSA-8854795)	0.725	5
UniProt:Q9UBC2 EPS15L1	2	EPS15L1 [plasma membrane] (R-HSA-182937) EPS15L1 [cytosol] (R-HSA-8935900)	0.725	5
UniProt:Q96CW1 AP2M1	6	AP2M1 [plasma membrane] (R-HSA-167585) AP2M1 [lysosomal membrane] (R-HSA-196144) AP2M1 [cytosol] (R-HSA-182227) AP2M1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130423) AP2M1 [endolysosome membrane] (R-HSA-6784828) p-T156 AP2M1 [cytosol] (R-HSA-8856805)	0.725	6
UniProt:Q15811 ITSN1	1	ITSN1 [cytosol] (R-HSA-3006481)	0.643	4
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.569	3
UniProt:Q96D71 REPS1	1	REPS1 [cytosol] (R-HSA-8862265)	0.527	2
UniProt:P49757 NUMB	1	NUMB [plasma membrane] (R-HSA-443595)	0.527	4
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.527	3
UniProt:Q8N6T3 ARFGAP1	1	ARFGAP1 [cytosol] (R-HSA-200464)	0.527	2
UniProt:P0CG47 UBB	20	UBB(77-152) [endocytic vesicle membrane] (R-HSA-939253) UBB(1-76) [endocytic vesicle membrane] (R-HSA-939231) UBB(153-228) [endocytic vesicle membrane] (R-HSA-939171) Ub-33-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783023) Ub-109-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783008) Ub-185-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783046) Ub-215-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783002) Ub-63-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783148) Ub-139-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783012) Ub-158-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783162) Ub-6-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783014) Ub-82-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783015) Ub-163-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783025) Ub-87-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6782998) Ub-11-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783109) Ub-124-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783131) Ub-200-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783100) Ub-48-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783165) Ub-181-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783160) Ub-29-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783070)	0.527	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4