Reactome | AP2S1 [clathrin-coated endocytic vesicle membrane]

AP2S1 [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-HSA-2130707

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

AP-2 complex subunit sigma, Adaptor protein complex AP-2 subunit sigma, Plasma membrane adapto AP-2 17 kDa protein

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by WNT (Homo sapiens)
  - Beta-catenin independent WNT signaling (Homo sapiens)
    - PCP/CE pathway (Homo sapiens)
      - WNT5A-dependent internalization of FZD4 (Homo sapiens)
        
        WNT5A:FZD4 is endocytosed (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2:AP-2:clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        clathrin:AP-2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 Complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP2S1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P53680 AP2S1

Gene Names

AP2S1, AP17, CLAPS2

Chain

chain:1-142

Reference Genes

BioGPS Gene:1175 AP2S1

COSMIC (genes):AP2S1 AP2S1

CTD Gene:1175 AP2S1

dbSNP Gene:1175 AP2S1

ENSEMBL:ENSG00000042753 AP2S1

ENSEMBL:ENSG00000042753.12 AP2S1

HGNC:565 AP2S1

KEGG Gene (Homo sapiens):1175 AP2S1

Monarch:1175 AP2S1

NCBI Gene:1175 AP2S1

OMIM:602242 AP2S1

UCSC:P53680 AP2S1

Reference Transcript

Other Identifiers

11716610_a_at

11716611_x_at

1175

11755456_a_at

16873647

202120_PM_x_at

202120_x_at

208074_PM_s_at

208074_s_at

211047_PM_x_at

211047_x_at

2483096

3866303

3866304

3866305

3866306

3866307

3866310

3866315

3866316

39347_at

8037847

A_33_P3346663

GE82612

GE86174

GO:0005515

GO:0005737

GO:0005764

GO:0005768

GO:0005773

GO:0005829

GO:0005886

GO:0005905

GO:0006886

GO:0006897

GO:0009898

GO:0015031

GO:0016020

GO:0016192

GO:0030100

GO:0030117

GO:0030122

GO:0030666

GO:0030669

GO:0031410

GO:0035615

GO:0036020

GO:0043226

GO:0043231

GO:0045202

GO:0045334

GO:0048268

GO:0048488

GO:0060090

GO:0065003

GO:0071944

GO:0072583

GO:0098793

GO:0098794

GO:0098884

HMNXSV003057421

ILMN_1662426

ILMN_1809957

PH_hs_0035544

TC19001658.hg

X97074_at

g11038642_3p_s_at

g13623468_3p_s_at

Participates

as a component of

AP-2 Complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Other forms of this molecule

AP2S1 [endolysosome membrane]

AP2S1 [cytosol]

AP2S1 [plasma membrane]

Inferred To

AP-2sigma [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)

ap2s1 [clathrin-coated endocytic vesicle membrane] (Xenopus tropicalis)

AP2S1 [clathrin-coated endocytic vesicle membrane] (Bos taurus)

AP2S1 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)

AP2S1 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)

aps-2 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)

Ap2s1 [clathrin-coated endocytic vesicle membrane] (Mus musculus)

Ap2s1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)

zgc:65827 [clathrin-coated endocytic vesicle membrane] (Danio rerio)

Cross References

RefSeq

NP_067586.1, NP_001288010.1, NP_001288005.1, NP_001288007.1, NP_004060.2

OpenTargets

ENSG00000042753

HPA

ENSG00000042753-AP2S1

GeneCards

P53680

Ensembl

ENSP00000470898, ENST00000263270, ENSG00000042753, ENSP00000263270, ENST00000601649

PRO

P53680

Pharos - Targets

P53680

Orphanet

21725

PDB

6URI

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.569	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.527	3
UniProt:P42566 EPS15	2	p-Y849 EPS15 [cytosol] (R-HSA-8867028) EPS15 [cytosol] (R-HSA-182920)	0.527	2

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