Reactome | PARD3 [cell junction]

PARD3 [cell junction]

Stable Identifier

R-HSA-2134481

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cell junction

Synonyms

Partitioning defective 3 homolog, PARD3_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by TGFB family members (Homo sapiens)
  - Signaling by TGF-beta Receptor Complex (Homo sapiens)
    - TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) (Homo sapiens)
      - Disassembly of tight junctions (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction] (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        Tight Junction Complex:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        PARD3:p-PARD6A:PRKCZ [cell junction] (Homo sapiens)
        
        PARD3 [cell junction] (Homo sapiens)
      - SMURF1 binds phosphorylated PARD6A (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        Tight Junction Complex:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        PARD3:p-PARD6A:PRKCZ [cell junction] (Homo sapiens)
        
        PARD3 [cell junction] (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        Tight Junction Complex:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        PARD3:p-PARD6A:PRKCZ [cell junction] (Homo sapiens)
        
        PARD3 [cell junction] (Homo sapiens)
      - SMURF1 ubiquitinates RHOA (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        Tight Junction Complex:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        PARD3:p-PARD6A:PRKCZ [cell junction] (Homo sapiens)
        
        PARD3 [cell junction] (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction] (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        Tight Junction Complex:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        PARD3:p-PARD6A:PRKCZ [cell junction] (Homo sapiens)
        
        PARD3 [cell junction] (Homo sapiens)
      - TGFBR1 is recruited to tight junctions by PARD6A (Homo sapiens)
        
        Tight Junction Complex:PARD6A:RHOA [cell junction] (Homo sapiens)
        
        PARD3:PARD6A:PRKCZ [cell junction] (Homo sapiens)
        
        PARD3 [cell junction] (Homo sapiens)
        
        Tight Junction Complex:TGFBR1:PARD6A:RHOA [cell junction] (Homo sapiens)
        
        Tight Junction Complex:PARD6A:RHOA [cell junction] (Homo sapiens)
        
        PARD3:PARD6A:PRKCZ [cell junction] (Homo sapiens)
        
        PARD3 [cell junction] (Homo sapiens)
      - TGFBR2 is recruited to tight junctions after TGF-beta stimulation (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:TGFBR1:PARD6A:RHOA [cell junction] (Homo sapiens)
        
        Tight Junction Complex:PARD6A:RHOA [cell junction] (Homo sapiens)
        
        PARD3:PARD6A:PRKCZ [cell junction] (Homo sapiens)
        
        PARD3 [cell junction] (Homo sapiens)
        
        Tight Junction Complex:TGFBR1:PARD6A:RHOA [cell junction] (Homo sapiens)
        
        Tight Junction Complex:PARD6A:RHOA [cell junction] (Homo sapiens)
        
        PARD3:PARD6A:PRKCZ [cell junction] (Homo sapiens)
        
        PARD3 [cell junction] (Homo sapiens)
      - TGFBR2 phosphorylates TGFBR1 and PARD6A (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:TGFBR1:PARD6A:RHOA [cell junction] (Homo sapiens)
        
        Tight Junction Complex:PARD6A:RHOA [cell junction] (Homo sapiens)
        
        PARD3:PARD6A:PRKCZ [cell junction] (Homo sapiens)
        
        PARD3 [cell junction] (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        Tight Junction Complex:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        PARD3:p-PARD6A:PRKCZ [cell junction] (Homo sapiens)
        
        PARD3 [cell junction] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8TEW0 PARD3

Gene Names

PARD3, PAR3, PAR3A

Chain

chain:1-1356

Reference Genes

BioGPS Gene:56288 PARD3

COSMIC (genes):PARD3 PARD3

CTD Gene:56288 PARD3

dbSNP Gene:56288 PARD3

ENSEMBL:ENSG00000148498 PARD3

ENSEMBL_homo_sapiens_GENE:ENSG00000148498.17 PARD3

HGNC:16051 PARD3

KEGG Gene (Homo sapiens):56288 PARD3

Monarch:56288 PARD3

NCBI Gene:56288 PARD3

OMIM:606745 PARD3

UCSC:Q8TEW0 PARD3

Reference Transcript

Other Identifiers

11744454_a_at

11745274_a_at

11758894_at

11759922_a_at

16713230

210094_PM_s_at

210094_s_at

221280_PM_s_at

221280_s_at

221526_PM_x_at

221526_x_at

221527_PM_s_at

221527_s_at

3284601

3284602

3284603

3284604

3284605

3284611

3284617

3284654

3284657

3284665

3284666

3284670

3284677

3284681

3284683

3284684

3284685

3284693

3284694

3284695

3284696

3284697

3284698

3284699

3284701

3284702

3284706

3284708

3284715

3284718

3284732

3284783

3284792

3284793

40973_at

45386_at

46674_at

56288

76542_at

7933010

83217_at

A_23_P201963

A_24_P35478

A_33_P3303372

GE55614

GE80842

GO:0000226

GO:0005515

GO:0005546

GO:0005547

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0005911

GO:0005912

GO:0005923

GO:0005938

GO:0006612

GO:0006886

GO:0007010

GO:0007049

GO:0007155

GO:0007163

GO:0007205

GO:0007409

GO:0008104

GO:0008289

GO:0008356

GO:0010801

GO:0012505

GO:0016020

GO:0016324

GO:0022011

GO:0023052

GO:0030010

GO:0030054

GO:0030154

GO:0031643

GO:0032266

GO:0033269

GO:0034330

GO:0035091

GO:0036211

GO:0043226

GO:0043296

GO:0045197

GO:0048856

GO:0051301

GO:0051660

GO:0065003

GO:0070160

GO:0070161

GO:0070830

GO:0090162

GO:0120157

HMNXSV003025426

HMNXSV003036141

HMNXSV003055658

Hs.72249.0.A1_3p_a_at

ILMN_1710524

PH_hs_0027144

TC10001170.hg

TC10002555.hg

g13491609_3p_a_at

g9665241_3p_a_at

Participates

as a component of

Other forms of this molecule

PARD3 [plasma membrane]

PARD3 [cytosol]

Inferred To

baz [cell junction] (Drosophila melanogaster)

Pard3 [cell junction] (Mus musculus)

Pard3 [cell junction] (Rattus norvegicus)

bazooka [cell junction] (Danio rerio)

par-3 [cell junction] (Caenorhabditis elegans)

pard3 [cell junction] (Xenopus tropicalis)

PARD3 [cell junction] (Bos taurus)

PARD3 [cell junction] (Canis familiaris)

PARD3 [cell junction] (Gallus gallus)

PARD3 [cell junction] (Sus scrofa)

Cross References

RefSeq

NP_001171721.1, NP_001171718.1, NP_001171723.1, NP_001171719.1, NP_001171714.1, NP_062565.2, NP_001171717.1, NP_001171722.1, NP_001171720.1, NP_001171716.1, NP_001171715.1

OpenTargets

ENSG00000148498

GeneCards

Q8TEW0

HPA

ENSG00000148498-PARD3

Ensembl

ENST00000374776, ENST00000374789, ENST00000374788, ENSP00000443147, ENSG00000148498, ENSP00000311986, ENST00000350537, ENSP00000440857, ENST00000545693, ENSP00000340591, ENST00000340077, ENSP00000363920, ENST00000374794, ENSP00000363908, ENST00000545260, ENSP00000341844, ENSP00000363921, ENSP00000363926, ENST00000346874

PRO

Q8TEW0

Pharos - Targets

Q8TEW0

HMDB Protein

HMDBP08503

PDB

2KOM

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.797	8
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.776	7
UniProt:P41743 PRKCI	3	PRKCI [nucleoplasm] (R-HSA-9021345) PRKCI [cytosol] (R-HSA-58206) PRKCI [plasma membrane] (R-HSA-420005)	0.623	5
UniProt:Q62074	3	PRKCI [plasma membrane] (R-MMU-420005) PRKCI [cytosol] (R-MMU-58206) PRKCI [nucleoplasm] (R-MMU-9021345)	0.611	7
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.536	2
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.536	4
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.499	3
UniProt:Q15831 STK11	2	STK11 [cytosol] (R-HSA-380954) STK11 [nucleoplasm] (R-HSA-164119)	0.463	2