Reactome | p-S345-PARD6A [plasma membrane]

p-S345-PARD6A [plasma membrane]

Stable Identifier

R-HSA-2134533

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

p-PARD6A

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by TGFB family members (Homo sapiens)
  - Signaling by TGF-beta Receptor Complex (Homo sapiens)
    - TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) (Homo sapiens)
      - Disassembly of tight junctions (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction] (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        Tight Junction Complex:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        PARD3:p-PARD6A:PRKCZ [cell junction] (Homo sapiens)
        
        p-S345-PARD6A [plasma membrane] (Homo sapiens)
      - SMURF1 binds phosphorylated PARD6A (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        Tight Junction Complex:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        PARD3:p-PARD6A:PRKCZ [cell junction] (Homo sapiens)
        
        p-S345-PARD6A [plasma membrane] (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        Tight Junction Complex:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        PARD3:p-PARD6A:PRKCZ [cell junction] (Homo sapiens)
        
        p-S345-PARD6A [plasma membrane] (Homo sapiens)
      - SMURF1 ubiquitinates RHOA (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        Tight Junction Complex:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        PARD3:p-PARD6A:PRKCZ [cell junction] (Homo sapiens)
        
        p-S345-PARD6A [plasma membrane] (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction] (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        Tight Junction Complex:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        PARD3:p-PARD6A:PRKCZ [cell junction] (Homo sapiens)
        
        p-S345-PARD6A [plasma membrane] (Homo sapiens)
      - TGFBR2 phosphorylates TGFBR1 and PARD6A (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        Tight Junction Complex:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        PARD3:p-PARD6A:PRKCZ [cell junction] (Homo sapiens)
        
        p-S345-PARD6A [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NPB6 PARD6A

Gene Names

PARD6A, PAR6A

Chain

chain:1-346

Reference Genes

COSMIC (genes):PARD6A PARD6A

dbSNP Gene:50855 PARD6A

ENSEMBL:ENSG00000102981 PARD6A

Participates

as a component of

PARD3:p-PARD6A:PRKCZ [cell junction] (Homo sapiens)

Other forms of this molecule

PARD6A [plasma membrane]

PARD6A [cytosol]

PARD6A [cell junction]

Inferred To

phospho-par-6 [plasma membrane] (Caenorhabditis elegans)

phospho-par-6 [plasma membrane] (Drosophila melanogaster)

Ghost homologue of p-S345-PARD6A [plasma membrane] (Xenopus tropicalis)

phospho-pard6a [plasma membrane] (Danio rerio)

phospho-Pard6a [plasma membrane] (Mus musculus)

phospho-Pard6a [plasma membrane] (Rattus norvegicus)

phospho-PARD6A [plasma membrane] (Bos taurus)

phospho-PARD6A [plasma membrane] (Canis familiaris)

phospho-PARD6A [plasma membrane] (Gallus gallus)

phospho-PARD6A [plasma membrane] (Sus scrofa)

Modified Residues

Name

O-phospho-L-serine at 345

Coordinate

345

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P41743 PRKCI	3	PRKCI [nucleoplasm] (R-HSA-9021345) PRKCI [cytosol] (R-HSA-58206) PRKCI [plasma membrane] (R-HSA-420005)	0.949	17
UniProt:Q05513 PRKCZ	5	pS, p-T410-PRKCZ [cytosol] (R-HSA-9632824) PRKCZ [cytosol] (R-HSA-58218) p-T410,T563-PRKCZ [cytosol] (R-HSA-5218698) p-T410-PRKCZ [cytosol] (R-HSA-437181) PRKCZ [cell junction] (R-HSA-2134483)	0.906	10
UniProt:P60953 CDC42	3	CDC42 [cytosol] (R-HSA-442630) CDC42 [plasma membrane] (R-HSA-449545) CDC42 [endoplasmic reticulum membrane] (R-HSA-5672086)	0.755	7
UniProt:P63000 RAC1	6	RAC1 [plasma membrane] (R-HSA-351141) RAC1 [cytosol] (R-HSA-442615) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076)	0.508	2