Reactome | Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)

Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)

Stable Identifier

R-HSA-2142670

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)

Click the image above or here to open this pathway in the Pathway Browser

The epoxidation of arachidonate by cytochrome P450s (CYPs) results in the formation of unique bioactive lipid mediators termed epoxyeicosatrienoates (EETs). Each double bond has been shown to be susceptible to oxidation, resulting in 5,6-EET, 8,9-EET, 11,12-EET, and 14,15-EET. The majority of the EET biological activities are diminished by the hydrolysis to the corresponding dihydroxyeicosatrienoates (DHET) (Capdevila et al. 2000, Buczynski et al. 2009, Vance & Vance 2008).

Literature References

PubMed ID	Title	Journal	Year
10681399	Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase Capdevila, JH, Falck, JR, Harris, RC	J Lipid Res	2000
	Biochemistry of Lipids, Lipoproteins and Membranes, 5th Edition Vance, DE, Vance, JE		2008
19244215	Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology Buczynski, MW, Dumlao, DS, Dennis, EA	J Lipid Res	2009