Synthesis of Leukotrienes (LT) and Eoxins (EX)

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Homo sapiens
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Leukotrienes (LTs) are biologically active molecules formed in response to inflammatory stimuli. They cause contraction of bronchial smooth muscles, stimulation of vascular permeability, and attraction and activation of leukocytes. LTs were discovered in 1938 and were termed the "slow release substance" (SRS) until their structures were determined in 1979 and they were then renamed to leukotrienes. LTs are derived from arachidonic acid through action by arachidonate 5-lipoxygenase (ALOX5). Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are generated as products derived from leukotriene A4 (LTA4). Eoxins are generated from leukotrienes (LTs) and resemble cysteinyl leukotrienes but have a different three-dimensional structure (Murphy & Gijon 2007, Hammarstrom 1983, MA.Claesson 2009, Vance & Vance 2008, Buczynski et al. 2009).

Literature References
PubMed ID Title Journal Year
6311078 Leukotrienes

Hammarström, S

Annu Rev Biochem 1983
17623009 Biosynthesis and metabolism of leukotrienes

Gijon, MA, Murphy, RC

Biochem J 2007
19130894 On the biosynthesis and biological role of eoxins and 15-lipoxygenase-1 in airway inflammation and Hodgkin lymphoma

Claesson, HE

Prostaglandins Other Lipid Mediat 2009
  Biochemistry of Lipids, Lipoproteins and Membranes, 5th Edition

Vance, JE, Vance, DE

19244215 Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology

Dumlao, DS, Buczynski, MW, Dennis, EA

J Lipid Res 2009
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