Reactome | PTGDS [endoplasmic reticulum membrane]

PTGDS [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-2142814

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Prostaglandin-H2 D-isomerase, PTGDS_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q9BWT7 CAR10

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External Reference Information

External Reference

UniProt:P41222 PTGDS

Gene Names

PTGDS, PDS

Chain

signal peptide:1-22, chain:23-190

Reference Genes

BioGPS Gene:5730 PTGDS

COSMIC (genes):PTGDS PTGDS

CTD Gene:5730 PTGDS

dbSNP Gene:5730 PTGDS

ENSEMBL:ENSG00000107317 PTGDS

ENSEMBL_homo_sapiens_GENE:ENSG00000107317.13 PTGDS

HGNC:9592 PTGDS

KEGG Gene (Homo sapiens):5730 PTGDS

Monarch:5730 PTGDS

NCBI Gene:5730 PTGDS

OMIM:176803 PTGDS

UCSC:P41222 PTGDS

Reference Transcript

RefSeq:NM_000954.5 PTGDS

Other Identifiers

11756587_a_at

17091502

211748_3p_x_at

211748_PM_x_at

211748_x_at

212187_3p_x_at

212187_PM_x_at

212187_x_at

216_at

3195041

3195042

3195045

3195046

3195051

3195053

3195058

38406_f_at

38407_r_at

5730

80501_f_at

8159521

A_33_P3298159

GE79216

GO:0001516

GO:0002376

GO:0003824

GO:0004667

GO:0005501

GO:0005504

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005635

GO:0005737

GO:0005783

GO:0005789

GO:0005791

GO:0005794

GO:0006629

GO:0006631

GO:0006633

GO:0006693

GO:0008289

GO:0010467

GO:0016020

GO:0016192

GO:0016853

GO:0019371

GO:0022414

GO:0031965

GO:0036094

GO:0043226

GO:0043303

GO:0045187

GO:0048471

GO:0051384

GO:0070062

GO:2000255

HMNXSV003025301

Hs.8272.0.S1_3p_s_at

ILMN_1664464

M98539_at

g13543567_3p_s_at

Participates

as an output of

Expression of PTGDS in testis differentiation (Homo sapiens)

Inferred To

Dmel\CG44014 [endoplasmic reticulum membrane] (Drosophila melanogaster)

Homologues of PTGDS [endoplasmic reticulum membrane] (Danio rerio)

ptgds [endoplasmic reticulum membrane] (Xenopus tropicalis)

PTGDS [endoplasmic reticulum membrane] (Bos taurus)

PTGDS [endoplasmic reticulum membrane] (Canis familiaris)

PTGDS [endoplasmic reticulum membrane] (Danio rerio)

PTGDS [endoplasmic reticulum membrane] (Gallus gallus)

PTGDS [endoplasmic reticulum membrane] (Sus scrofa)

Ptgds [endoplasmic reticulum membrane] (Mus musculus)

Ptgds [endoplasmic reticulum membrane] (Rattus norvegicus)

ptgdsa [endoplasmic reticulum membrane] (Danio rerio)

Cross References

RefSeq

NP_000945.3

Guide to Pharmacology - Targets

1380

OpenTargets

ENSG00000107317

IntEnz

5.3.99.2

GeneCards

P41222

HPA

ENSG00000107317-PTGDS

Ensembl

ENSG00000107317, ENSP00000360687, ENST00000371625

PRO

P41222

Pharos - Targets

P41222

HMDB Protein

HMDBP01576

PDB

4ORY, 4IMN, 4OS8, 3O2Y, 3O19, 4OS0, 2WWP, 4ORU, 3O22, 8HTA, 4ORR, 5WY9, 4ORX, 4OS3, 4ORW, 4ORS, 4IMO

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P54253 ATX1			0.666	5
UniProt:Q9Y371 SHLB1			0.556	3
IntAct:EBI-10171679 386682			0.556	3
UniProt:Q9UHD9 UBQLN2	1	UBQLN2 [cytosol] (R-HSA-8866007)	0.556	6
UniProt:Q9BWT7 CAR10			0.556	3
UniProt:P60328 KRTAP12-3	1	KRTAP12-3 [cytosol] (R-HSA-6810284)	0.556	3
UniProt:P60409 KRTAP10-7	1	KRTAP10-7 [cytosol] (R-HSA-6810279)	0.556	3
UniProt:P13473-2 P134732			0.556	3
UniProt:A8MQ03 CRTP1			0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:P55212 CASP6	5	CASP6 (1-293) [cytosol] (R-HSA-6798132) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(194-293) [cytosol] (R-HSA-266128)	0.556	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:P02763 ORM1	4	ORM1 [platelet alpha granule lumen] (R-HSA-8848906) ORM1 [specific granule lumen] (R-HSA-6799632) ORM1 [extracellular region] (R-HSA-6799687) ORM1 [tertiary granule lumen] (R-HSA-6801026)	0.527	2

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