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p-T183-PRKAA1 [nucleoplasm]
Stable Identifier
R-HSA-2151206
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
p-T183-AMPK alpha1, 5'-AMP-activated protein kinase catalytic subunit alpha-1, AAPK1_HUMAN, PRKAA1
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
AMPK phosphorylates TP53 (Homo sapiens)
Activated AMPK heterotrimer [nucleoplasm] (Homo sapiens)
p-AMPK alpha [nucleoplasm] (Homo sapiens)
p-T183-PRKAA1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13131 PRKAA1
Gene Names
PRKAA1, AMPK1
Chain
chain:1-559
Reference Genes
BioGPS Gene:5562 PRKAA1
COSMIC (genes):PRKAA1 PRKAA1
CTD Gene:5562 PRKAA1
dbSNP Gene:5562 PRKAA1
ENSEMBL:ENSG00000132356 PRKAA1
ENSEMBL_homo_sapiens_GENE:ENSG00000132356.12 PRKAA1
HGNC:9376 PRKAA1
KEGG Gene (Homo sapiens):5562 PRKAA1
Monarch:5562 PRKAA1
NCBI Gene:5562 PRKAA1
OMIM:602739 PRKAA1
UCSC:Q13131 PRKAA1
Reference Transcript
RefSeq:NM_006251.5 PRKAA1
RefSeq:NM_206907.3 PRKAA1
Other Identifiers
11729314_a_at
11739209_a_at
11751517_a_at
16995685
209799_PM_at
209799_at
225984_PM_at
225984_at
225985_PM_at
225985_at
2854734
2854736
2854738
2854739
2854740
2854741
2854742
2854743
2854746
2854747
2854749
2854753
2854755
2854758
2854760
2854765
2854776
2854777
2854778
2854779
41015_at
48068_at
5562
8111796
A_23_P110725
A_33_P3257187
A_33_P3312212
GE53597
GE878012
GE895807
GO:0000166
GO:0000785
GO:0001666
GO:0003682
GO:0003824
GO:0004672
GO:0004674
GO:0004679
GO:0004691
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0005886
GO:0005975
GO:0006006
GO:0006091
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0006468
GO:0006629
GO:0006631
GO:0006633
GO:0006694
GO:0006695
GO:0006886
GO:0006914
GO:0007005
GO:0007010
GO:0007165
GO:0008092
GO:0008202
GO:0008203
GO:0008284
GO:0008610
GO:0009410
GO:0009411
GO:0009631
GO:0010332
GO:0010508
GO:0010628
GO:0010629
GO:0012501
GO:0014823
GO:0015721
GO:0016055
GO:0016126
GO:0016192
GO:0016301
GO:0016310
GO:0016324
GO:0016607
GO:0016740
GO:0019395
GO:0023052
GO:0030424
GO:0030425
GO:0031000
GO:0031331
GO:0031588
GO:0031669
GO:0032007
GO:0032991
GO:0033135
GO:0034599
GO:0035556
GO:0036211
GO:0038183
GO:0042149
GO:0042542
GO:0042593
GO:0042752
GO:0043025
GO:0043066
GO:0043226
GO:0043627
GO:0044877
GO:0045542
GO:0045821
GO:0045893
GO:0046318
GO:0046627
GO:0046872
GO:0047322
GO:0048156
GO:0048511
GO:0048643
GO:0048856
GO:0050321
GO:0050405
GO:0050896
GO:0050995
GO:0055086
GO:0055089
GO:0060627
GO:0061744
GO:0061762
GO:0062028
GO:0070050
GO:0070301
GO:0070507
GO:0071277
GO:0071333
GO:0071361
GO:0071380
GO:0071417
GO:0071456
GO:0071466
GO:0097009
GO:0106310
GO:0120188
GO:0140053
GO:0140096
GO:0140823
GO:1901135
GO:1903109
GO:1903829
GO:1903944
GO:1903955
GO:1904179
GO:1904262
GO:1904428
GO:1905691
GO:1990044
GO:2000758
HMNXSV003036598
Hs.107057.0.A1_3p_at
Hs.107057.0.A2_3p_at
ILMN_1783889
ILMN_2357577
PH_hs_0022119
TC05001298.hg
Y12856_at
g5410311_3p_at
Participates
as a member of
p-AMPK alpha [nucleoplasm] (Homo sapiens)
Other forms of this molecule
p-T183-PRKAA1 [cytosol]
PRKAA1 [cytosol]
Inferred To
phospho-p-T183-PRKAA1 [nucleoplasm]
(Bos taurus)
phospho-p-T183-PRKAA1 [nucleoplasm]
(Danio rerio)
phospho-p-T183-PRKAA1 [nucleoplasm]
(Drosophila melanogaster)
phospho-p-T183-PRKAA1 [nucleoplasm]
(Mus musculus)
phospho-p-T183-PRKAA1 [nucleoplasm]
(Rattus norvegicus)
Modified Residues
Name
O-phospho-L-threonine at 183
Coordinate
183
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_996790.3
,
NP_006242.5
Guide to Pharmacology - Targets
1541
OpenTargets
ENSG00000132356
IntEnz
2.7.11.31
,
2.7.11.26
GeneCards
Q13131
HPA
ENSG00000132356-PRKAA1
ZINC target
Q13131
Ensembl
ENSP00000346148
,
ENST00000354209
,
ENST00000397128
,
ENSG00000132356
,
ENSP00000380317
PRO
Q13131
Pharos - Targets
Q13131
HMDB Protein
HMDBP01899
PDB
4RER
,
4REW
,
5EZV
,
7JHG
,
6C9F
,
7JIJ
,
6C9H
,
7JHH
,
6C9J
,
7M74
,
4RED
,
6C9G
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O75385 ULK1
7
ULK1 [recycling endosome]
(R-HSA-8854761)
p-S758-ULK1 [cytosol]
(R-HSA-5672131)
p-S317,467,556,638,T575-ULK1 [cytosol]
(R-HSA-5673747)
p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol]
(R-HSA-5675858)
p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane]
(R-HSA-8948047)
ULK1 [cytosol]
(R-HSA-1632847)
ULK1 [mitochondrial outer membrane]
(R-HSA-8948145)
0.669
3
UniProt:Q13451 FKBP5
2
FKBP5 [cytosol]
(R-HSA-5618096)
FKBP5 [nucleoplasm]
(R-HSA-8939165)
0.643
3
UniProt:P46937 YAP1
8
p-Y407-YAP1 [cytosol]
(R-HSA-9865208)
p-S127-YAP1 [cytosol]
(R-HSA-2028553)
p-5S-YAP1 [cytosol]
(R-HSA-2028554)
p-Y407-YAP1 [nucleoplasm]
(R-HSA-8956661)
p-Y-YAP1 [cytosol]
(R-HSA-8937843)
p-Y-YAP1 [nucleoplasm]
(R-HSA-8937857)
YAP1 [cytosol]
(R-HSA-1253345)
YAP1 [nucleoplasm]
(R-HSA-1253322)
0.564
3
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.564
2
UniProt:O96006 ZBED1
1
ZBED1 [nucleoplasm]
(R-HSA-8956376)
0.556
3
UniProt:P14373 TRIM27
2
TRIM27 [nucleoplasm]
(R-HSA-2997690)
TRIM27 [cytosol]
(R-HSA-8851002)
0.556
3
UniProt:O14503 BHLHE40
1
BHLHE40 [nucleoplasm]
(R-HSA-879741)
0.556
3
UniProt:Q08117 TLE5
1
AES [nucleoplasm]
(R-HSA-4648963)
0.556
3
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.556
3
UniProt:P54646 PRKAA2
4
PRKAA2 [cytosol]
(R-HSA-200405)
p-T172-PRKAA2 [cytosol]
(R-HSA-200417)
p-T172-PRKAA2 [nucleoplasm]
(R-HSA-164171)
PRKAA2 [nucleoplasm]
(R-HSA-163682)
0.527
3
UniProt:P07900 HSP90AA1
8
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [cytosol]
(R-HSA-192864)
HSP90AA1 [lysosomal lumen]
(R-HSA-9622850)
0.527
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
3
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