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ITGB4 [plasma membrane]
Stable Identifier
R-HSA-215947
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Integrin beta-4
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Homo sapiens)
Cell junction organization (Homo sapiens)
Type I hemidesmosome assembly (Homo sapiens)
BP180 interacts extracellularly with Laminin 332 (Homo sapiens)
Integrin alpha 6:beta 4:Plectin:BP180:Laminin-322 complex [plasma membrane] (Homo sapiens)
Integrin alpha 6:beta 4:Plectin complex [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGB4 [plasma membrane] (Homo sapiens)
Integrin alpha6:beta4:Plectin:BP180 complex [plasma membrane] (Homo sapiens)
Integrin alpha 6:beta 4:Plectin complex [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGB4 [plasma membrane] (Homo sapiens)
BP180 interacts intracellularly with plectin and integrin beta4 (Homo sapiens)
Integrin alpha 6:beta 4:Plectin complex [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGB4 [plasma membrane] (Homo sapiens)
Integrin alpha6:beta4:Plectin:BP180 complex [plasma membrane] (Homo sapiens)
Integrin alpha 6:beta 4:Plectin complex [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGB4 [plasma membrane] (Homo sapiens)
BP230 interacts with keretin K5/K14 (Homo sapiens)
CD151:BP230:BP180:Plectin:Integrin alpha 6 beta 4: Laminin [plasma membrane] (Homo sapiens)
BP230:BP180:Plectin:integrin alpha 6 beta 4:Laminin 332 [plasma membrane] (Homo sapiens)
Integrin alpha 6:beta 4:Plectin:BP180:Laminin-322 complex [plasma membrane] (Homo sapiens)
Integrin alpha 6:beta 4:Plectin complex [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGB4 [plasma membrane] (Homo sapiens)
Type II hemidesmosome [plasma membrane] (Homo sapiens)
CD151:BP230:BP180:Plectin:Integrin alpha 6 beta 4: Laminin [plasma membrane] (Homo sapiens)
BP230:BP180:Plectin:integrin alpha 6 beta 4:Laminin 332 [plasma membrane] (Homo sapiens)
Integrin alpha 6:beta 4:Plectin:BP180:Laminin-322 complex [plasma membrane] (Homo sapiens)
Integrin alpha 6:beta 4:Plectin complex [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGB4 [plasma membrane] (Homo sapiens)
BP230 is recruited to the hemidesmosome (Homo sapiens)
BP230:BP180:Plectin:integrin alpha 6 beta 4:Laminin 332 [plasma membrane] (Homo sapiens)
Integrin alpha 6:beta 4:Plectin:BP180:Laminin-322 complex [plasma membrane] (Homo sapiens)
Integrin alpha 6:beta 4:Plectin complex [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGB4 [plasma membrane] (Homo sapiens)
Integrin alpha 6:beta 4:Plectin:BP180:Laminin-322 complex [plasma membrane] (Homo sapiens)
Integrin alpha 6:beta 4:Plectin complex [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGB4 [plasma membrane] (Homo sapiens)
CD151 interacts with BP180 and the integrin alpha 6 subunit (Homo sapiens)
BP230:BP180:Plectin:integrin alpha 6 beta 4:Laminin 332 [plasma membrane] (Homo sapiens)
Integrin alpha 6:beta 4:Plectin:BP180:Laminin-322 complex [plasma membrane] (Homo sapiens)
Integrin alpha 6:beta 4:Plectin complex [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGB4 [plasma membrane] (Homo sapiens)
CD151:BP230:BP180:Plectin:Integrin alpha 6 beta 4: Laminin [plasma membrane] (Homo sapiens)
BP230:BP180:Plectin:integrin alpha 6 beta 4:Laminin 332 [plasma membrane] (Homo sapiens)
Integrin alpha 6:beta 4:Plectin:BP180:Laminin-322 complex [plasma membrane] (Homo sapiens)
Integrin alpha 6:beta 4:Plectin complex [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGB4 [plasma membrane] (Homo sapiens)
Interaction of Plectin with Integrin beta 4 (Homo sapiens)
Integrin alpha 6:beta 4:Plectin complex [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGB4 [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGB4 [plasma membrane] (Homo sapiens)
Developmental Biology (Homo sapiens)
Developmental Cell Lineages (Homo sapiens)
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin (Homo sapiens)
Keratinocyte stem cell differentiates into transit amplifying cell in the basal layer of interfollicular epidermis (Homo sapiens)
keratinocyte stem cell of skin epidermis basal layer (Homo sapiens)
ITGB4 [plasma membrane] (Homo sapiens)
Extracellular matrix organization (Homo sapiens)
Collagen formation (Homo sapiens)
Assembly of collagen fibrils and other multimeric structures (Homo sapiens)
Hemidesmosome formation (Homo sapiens)
Collagen type XVII fibril:Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGB4 [plasma membrane] (Homo sapiens)
Type I hemidesmosome complex [extracellular region] (Homo sapiens)
Collagen type XVII fibril:Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGB4 [plasma membrane] (Homo sapiens)
Laminin interactions (Homo sapiens)
Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221) (Homo sapiens)
Integrin alpha3beta1, alpha6beta4 [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGB4 [plasma membrane] (Homo sapiens)
Integrin alpha3beta1, alpha6beta4:Laminins-332, 511, 521, (211, 221) [plasma membrane] (Homo sapiens)
Integrin alpha3beta1, alpha6beta4 [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGB4 [plasma membrane] (Homo sapiens)
Non-integrin membrane-ECM interactions (Homo sapiens)
Syndecan interactions (Homo sapiens)
Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Homo sapiens)
Integrin alpha2beta1, (alpha6beta4) [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGB4 [plasma membrane] (Homo sapiens)
Syndecan-1:Integrin alpha2beta1 (alpha6beta4) [plasma membrane] (Homo sapiens)
Integrin alpha2beta1, (alpha6beta4) [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGB4 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P16144 ITGB4
Gene Names
ITGB4
Chain
signal peptide:1-27, chain:28-1822
Reference Genes
COSMIC (genes):ITGB4 ITGB4
dbSNP Gene:3691 ITGB4
ENSEMBL:ENSG00000132470 ITGB4
Participates
as a protein marker of
keratinocyte stem cell of skin epidermis basal layer (Homo sapiens)
as a component of
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
Inferred To
pat-3 [plasma membrane]
(Caenorhabditis elegans)
ITGB4 [plasma membrane]
(Bos taurus)
ITGB4 [plasma membrane]
(Caenorhabditis elegans)
ITGB4 [plasma membrane]
(Canis familiaris)
ITGB4 [plasma membrane]
(Mus musculus)
ITGB4 [plasma membrane]
(Rattus norvegicus)
ITGB4 [plasma membrane]
(Sus scrofa)
Ghost homologue of ITGB4 [plasma membrane]
(Xenopus tropicalis)
Homologues of ITGB4 [plasma membrane]
(Caenorhabditis elegans)
Homologues of ITGB4 [plasma membrane]
(Drosophila melanogaster)
mys [plasma membrane]
(Drosophila melanogaster)
Itgbn [plasma membrane]
(Drosophila melanogaster)
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P48509 CD151
2
CD151 [cytosol]
(R-HSA-446072)
CD151 [plasma membrane]
(R-HSA-913947)
0.602
3
UniProt:Q15149 PLEC
3
PLEC(2396-4684) [cytosol]
(R-HSA-350618)
PLEC(1-2395) [cytosol]
(R-HSA-350638)
PLEC [cytosol]
(R-HSA-201575)
0.558
7
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.527
8
UniProt:Q05397 PTK2
11
p-6Y-PTK2 [cytosol]
(R-HSA-354128)
p-Y397-PTK2 [cytosol]
(R-HSA-354068)
PTK2 [cytosol]
(R-HSA-201621)
PTK2(1-772) [cytosol]
(R-HSA-202827)
PTK2(773-1052) [cytosol]
(R-HSA-202829)
p-5Y-PTK2 [cytosol]
(R-HSA-5218711)
p-5Y,S732-PTK2 [cytosol]
(R-HSA-5229006)
p-6Y,S732-PTK2 [cytosol]
(R-HSA-5218694)
pY-PTK2 [cytosol]
(R-HSA-9632393)
p-Y194,Y397-PTK2 [cytosol]
(R-HSA-8874600)
p-Y194,Y397,Y576,Y577-PTK2 [cytosol]
(R-HSA-8874613)
0.524
7
UniProt:Q99500 S1PR3
1
S1PR3 [plasma membrane]
(R-HSA-419396)
0.471
3
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