Reactome | TACC3 [cytosol]

TACC3 [cytosol]

Stable Identifier

R-HSA-2160956

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Transforming acidic coiled-coil-containing protein 3, ERIC1

Locations in the PathwayBrowser for interactor UniProt:A5D8V6 VPS37C

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External Reference Information

External Reference

UniProt:Q9Y6A5 TACC3

Gene Names

TACC3, ERIC1

Chain

initiator methionine:, chain:2-838

Reference Genes

BioGPS Gene:10460 TACC3

COSMIC (genes):TACC3 TACC3

CTD Gene:10460 TACC3

dbSNP Gene:10460 TACC3

ENSEMBL:ENSG00000013810 TACC3

HGNC:11524 TACC3

KEGG:hsa:10460 TACC3

Monarch:10460 TACC3

NCBI Gene:10460 TACC3

OMIM:605303 TACC3

UCSC:Q9Y6A5 TACC3

Reference Transcript

Other Identifiers

10460

11718297_a_at

11746461_a_at

11760423_at

11760424_x_at

11763455_a_at

11763456_x_at

1569487_PM_at

1569487_at

16964000

218308_PM_at

218308_at

2714950

2714956

2714957

2714958

2714959

2714961

2714962

2714968

2714969

2714970

2714971

2714972

2714973

2714974

2714975

2714977

2714978

2714979

2714980

2714981

2714982

2714983

2714984

2714985

2714986

2714987

2714988

2714989

2714990

2714991

2714992

2714994

2714995

2714996

2714997

2714998

2714999

52238_s_at

52239_r_at

8093500

A_14_P128134

A_23_P212844

GE58400

GO:0000226

GO:0000922

GO:0005515

GO:0005737

GO:0005813

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0007010

GO:0007052

GO:0007091

GO:0008283

GO:0021987

GO:0034451

GO:0043226

GO:0043231

GO:0048856

GO:0051301

GO:0060236

GO:0072686

GO:1902850

HMNXSV003007489

Hs2.396824.1.S1_3p_at

ILMN_1724407

PH_hs_0005773

TC04000028.hg

g5454101_3p_at

Participates

as a component of

as an input of

Cross References

OpenTargets

ENSG00000013810

ENSEMBL

ENSP00000498361, ENST00000651472, ENST00000313288, ENSP00000326550

HPA

ENSG00000013810-TACC3

PRO

Q9Y6A5

Pharos - Targets

Q9Y6A5

GlyGen

Q9Y6A5

PDB

5LXO, 5LXN, 5ODT, 5ODS

Interactors (36)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14008 CKAP5	1	CKAP5 [cytosol] (R-HSA-377729)	0.819	10
UniProt:Q9NU19 TB22B			0.781	7
UniProt:Q2M2Z5 KIZ			0.718	6
UniProt:Q96Q77 CIB3			0.718	9
UniProt:Q9P270 SLAI2			0.643	4
UniProt:Q53EZ4 CEP55			0.621	3
UniProt:Q2WGJ6 KLH38			0.601	4
UniProt:A2AGT5	1	Ckap5 [cytosol] (R-MMU-377729)	0.564	2
UniProt:Q9BXY8 BEX2			0.556	3
UniProt:Q00994 BEX3	1	NGFRAP1 [cytosol] (R-HSA-194333)	0.556	3
UniProt:Q07866-2 KLC1			0.556	3
UniProt:A5D8V6 VPS37C	1	VPS37C [endosome membrane] (R-HSA-184438)	0.556	3
UniProt:Q99988 GDF15			0.556	3
UniProt:Q9BZE9 ASPSCR1	1	ASPSCR1 [cytoplasmic vesicle membrane] (R-HSA-1449582)	0.556	3
UniProt:Q8TC71 MIEAP			0.556	3
UniProt:Q53TS8 CTSRT			0.556	3
UniProt:Q99819 ARHGDIG	1	ARHGDIG [cytosol] (R-HSA-195087)	0.556	3
UniProt:Q9GZM8 NDEL1	1	NDEL1 [cytosol] (R-HSA-376258)	0.556	3
UniProt:Q86Y33-5 CDC20B			0.556	3
UniProt:Q7Z3B4 NUP54	2	NUP54 [cytosol] (R-HSA-9634221) NUP54 [nuclear envelope] (R-HSA-157724)	0.556	3
UniProt:Q96DY2-2 Q96DY22			0.556	3
UniProt:Q8TD31-3 CCHCR1			0.556	3
UniProt:Q7Z614 SNX20			0.556	3
UniProt:Q5VTR2 RNF20	2	RNF20 [cytosol] (R-HSA-9715141) RNF20 [nucleoplasm] (R-HSA-5689011)	0.556	3
UniProt:P16562 CRIS2			0.527	2
UniProt:O43482 OIP5	1	OIP5 [nucleoplasm] (R-HSA-606286)	0.527	2
UniProt:O14965 AURKA	6	p-T288-AURKA [cytosol] (R-HSA-2574832) AURKA [cytosol] (R-HSA-174254) p-T288-AURKA [nucleoplasm] (R-HSA-6805089) AURKA [nucleoplasm] (R-HSA-4655443) PolyUb-AURKA [cytosol] (R-HSA-8854040) SUMO1-K258-AURKA [cytosol] (R-HSA-4655367)	0.527	2
UniProt:Q8N8S7 ENAH	1	ENAH [cytosol] (R-HSA-426406)	0.527	2
UniProt:Q03426 MVK	1	MVK [cytosol] (R-HSA-191375)	0.527	2
UniProt:P11142 HSPA8	10	HSPA8 [cytosol] (R-HSA-264476) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217)	0.527	2
UniProt:P50552 VASP	1	VASP [cytosol] (R-HSA-446323)	0.527	2
UniProt:Q96GS4 BORC6			0.527	3
UniProt:O95721 SNAP29	3	SNAP29 [azurophil granule membrane] (R-HSA-6799359) SNAP29 [plasma membrane] (R-HSA-2029020) SNAP29 [Golgi membrane] (R-HSA-6810997)	0.527	2
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.508	3
UniProt:P09496 CLTA	6	CLTA [cytosol] (R-HSA-8856817) CLTA [trans-Golgi network membrane] (R-HSA-5333758) CLTA [endolysosome membrane] (R-HSA-8870825) CLTA [clathrin-coated endocytic vesicle membrane] (R-HSA-5138427) CLTA [lysosomal membrane] (R-HSA-2980595) CLTA [plasma membrane] (R-HSA-2980611)	0.499	3
UniProt:Q9Y6A5 TACC3	1	TACC3 [cytosol] (R-HSA-2160956)	0.488	2

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