Reactome | SIRT2 [cytosol]

SIRT2 [cytosol]

Stable Identifier

R-HSA-2161118

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

NAD-dependent deacetylase sirtuin-2

Locations in the PathwayBrowser for interactor UniProt:Q9UBN7%20HDAC6

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Metaphase and Anaphase (Homo sapiens)
      - Mitotic Anaphase (Homo sapiens)
        
        Nuclear Envelope (NE) Reassembly (Homo sapiens)
        
        Initiation of Nuclear Envelope (NE) Reformation (Homo sapiens)
        
        ANKLE2 is deacetylated by SIRT2 (Homo sapiens)
        
        SIRT2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8IXJ6 SIRT2

Gene Names

SIRT2, SIR2L, SIR2L2

Chain

initiator methionine:, chain:2-389

Reference Genes

BioGPS Gene:22933 SIRT2

COSMIC (genes):SIRT2 SIRT2

CTD Gene:22933 SIRT2

dbSNP Gene:22933 SIRT2

ENSEMBL:ENSG00000068903 SIRT2

ENSEMBL_homo_sapiens_GENE:ENSG00000068903.21 SIRT2

ENSEMBL_homo_sapiens_GENE:ENSG00000283100.2 SIRT2

HGNC:10886 SIRT2

KEGG Gene (Homo sapiens):22933 SIRT2

Monarch:22933 SIRT2

NCBI Gene:22933 SIRT2

OMIM:604480 SIRT2

UCSC:Q8IXJ6 SIRT2

Reference Transcript

Other Identifiers

11715768_x_at

11748220_a_at

16872089

220605_PM_s_at

220605_s_at

22933

3861690

3861691

3861692

3861693

3861694

3861696

3861697

3861700

3861701

3861702

3861703

3861704

3861705

3861707

3861708

3861710

3861711

3861712

3861714

3861721

3861725

3861726

56491_at

8036636

A_23_P142455

A_33_P3258946

A_33_P3271800

GE58472

GO:0000122

GO:0000183

GO:0000278

GO:0000781

GO:0000792

GO:0002376

GO:0003682

GO:0003824

GO:0003950

GO:0004407

GO:0005515

GO:0005634

GO:0005677

GO:0005694

GO:0005730

GO:0005737

GO:0005739

GO:0005813

GO:0005814

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0005874

GO:0005886

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0006476

GO:0006629

GO:0006914

GO:0007049

GO:0007059

GO:0007084

GO:0007096

GO:0007399

GO:0008270

GO:0010507

GO:0010801

GO:0012501

GO:0016020

GO:0016575

GO:0016740

GO:0016787

GO:0017136

GO:0021762

GO:0022011

GO:0022414

GO:0030154

GO:0030163

GO:0030426

GO:0030496

GO:0031507

GO:0031509

GO:0031641

GO:0032200

GO:0032436

GO:0033010

GO:0033270

GO:0033558

GO:0034599

GO:0034979

GO:0034983

GO:0035035

GO:0036211

GO:0040029

GO:0042177

GO:0042325

GO:0042826

GO:0042903

GO:0042995

GO:0043130

GO:0043161

GO:0043204

GO:0043209

GO:0043219

GO:0043220

GO:0043226

GO:0043388

GO:0044224

GO:0044242

GO:0044546

GO:0045087

GO:0045598

GO:0045599

GO:0045723

GO:0045836

GO:0045843

GO:0045892

GO:0045944

GO:0046872

GO:0046970

GO:0048471

GO:0048856

GO:0051287

GO:0051301

GO:0051321

GO:0051726

GO:0051775

GO:0051781

GO:0051987

GO:0061024

GO:0061428

GO:0061433

GO:0065003

GO:0070403

GO:0070446

GO:0071456

GO:0071872

GO:0072686

GO:0072687

GO:0090042

GO:0097386

GO:0098542

GO:0140013

GO:0140014

GO:0140096

GO:0140297

GO:0140773

GO:0140774

GO:1900119

GO:1900195

GO:1900226

GO:2000378

HMNXSV003021571

ILMN_1723494

ILMN_2398711

PH_hs_0018233

TC19002477.hg

g13775599_3p_s_at

Inferred To

SIRT2 [cytosol] (Bos taurus)

SIRT2 [cytosol] (Canis familiaris)

SIRT2 [cytosol] (Danio rerio)

SIRT2 [cytosol] (Drosophila melanogaster)

SIRT2 [cytosol] (Gallus gallus)

SIRT2 [cytosol] (Mus musculus)

SIRT2 [cytosol] (Rattus norvegicus)

SIRT2 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_001180215.1, NP_085096.1, NP_036369.2, XP_006723174.1, XP_011524957.1, XP_011524956.1

ZINC - World Drugs

SIR2_HUMAN

Guide to Pharmacology - Targets

2708

OpenTargets

ENSG00000068903

ZINC - FDA approved

SIR2_HUMAN

ZINC - Substances

SIR2_HUMAN

ZINC target

Q8IXJ6

ZINC - Biogenic

SIR2_HUMAN

PRO

Q8IXJ6

PDB

5YQM, 4R8M, 5DY5, 6L71, 6QCN, 1J8F, 3ZGV, 5Y0Z, 4RMJ, 4X3P, 5YQL, 5DY4, 4Y6Q, 3ZGO, 6NR0, 6L66, 4X3O, 5D7P, 4Y6O, 4RMH, 5MAR, 6L65, 4RMI, 5MAT, 5G4C, 5D7Q, 5YQO, 7BOT, 5FYQ, 5YQN, 5D7O, 4RMG, 6L72, 4Y6L, 4L3O, 5Y5N, 7BOS

ZINC - Investigational

SIR2_HUMAN

ZINC - Metabolites

SIR2_HUMAN

GeneCards

Q8IXJ6

HPA

ENSG00000068903-SIRT2

Ensembl

ENST00000392081, ENSP00000488940, ENSG00000283100, ENSG00000068903, ENST00000249396, ENSP00000489602, ENSP00000249396, ENST00000634533, ENST00000635478, ENSP00000375931

Pharos - Targets

Q8IXJ6

ZINC - Predictions - Purchasable

SIR2_HUMAN

HMDB Protein

HMDBP08880

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92831 KAT2B	1	KAT2B [nucleoplasm] (R-HSA-352430)	0.576	4
UniProt:O60566 BUB1B	1	BUB1B [cytosol] (R-HSA-141436)	0.576	3
UniProt:Q04206 RELA	6	MeK310-RELA [nucleoplasm] (R-HSA-8865233) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) p-S276-RELA [nucleoplasm] (R-HSA-5624468) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676)	0.544	2
UniProt:P11413 G6PD	1	G6PD [cytosol] (R-HSA-70372)	0.524	3
UniProt:O60729 CDC14B	1	CDC14B [nucleoplasm] (R-HSA-3214897)	0.524	2
UniProt:Q9BYB0 SHANK3	1	SHANK3 [cytosol] (R-HSA-6794277)	0.508	2
UniProt:Q9UBN7 HDAC6	4	HDAC6 [nucleoplasm] (R-HSA-351589) HDAC6 [late endosome lumen] (R-HSA-9659980) HDAC6 [cytosol] (R-HSA-5324660) HDAC6 [lysosomal lumen] (R-HSA-9660002)	0.463	2
UniProt:Q9UM11 FZR1	4	FZR1 [cytosol] (R-HSA-174249) FZR1 [nucleoplasm] (R-HSA-174099) p-FZR1 [nucleoplasm] (R-HSA-174257) p-FZR1 [cytosol] (R-HSA-174193)	0.462	2
UniProt:P15172 MYOD1	1	MYOD1 [nucleoplasm] (R-HSA-445441)	0.462	2