Reactome | 20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3

20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3

Stable Identifier

R-HSA-2161745

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

Synonyms

20-hydroxy-leukotriene B4 + O2 + reduced (NADPH--hemoprotein reductase) => 20-oxo-leukotriene B4 + H(+) + 2 H2O + oxidized (NADPH--hemoprotein reductase)

ReviewStatus

5/5

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20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3

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The cytochrome P450s 4F2 (CYP4F2) and F3 (CYP4F3) oxidise the omega hydroxylated metabolite, 20-hydroxyleukotriene B4 (20oh-LTB4) to form 20-aldehyde leukotriene B4 (20cho-LTB4) (Soberman et al. 1988).

Literature References

PubMed ID	Title	Journal	Year
2836406	The identification and formation of 20-aldehyde leukotriene B4 Sutyak, JP, Soberman, RJ, Okita, RT, Roberts LJ, 2nd, Wendelborn, DF, Austen, KF	J Biol Chem	1988