LXA4 is oxidised to 15k-LXA4 by HPGD

Stable Identifier
R-HSA-2161779
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
lipoxin A4 + NAD(+) => 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH
ReviewStatus
5/5
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LXA4 is oxidised to 15k-LXA4 by HPGD
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
15-Hydroxyprostaglandin dehydrogenase (HPGD) converts lipoxin A4 (LXA4) to 15-oxo lipoxin A4 aka 15-keto-LXA4 (15k-LXA4) (Clish et al. 2000).
Literature References
PubMed ID Title Journal Year
10837478 Oxidoreductases in lipoxin A4 metabolic inactivation: a novel role for 15-oxoprostaglandin 13-reductase/leukotriene B4 12-hydroxydehydrogenase in inflammation

Tai, HH, Serhan, CN, Clish, CB, Chiang, N, Levy, BD

J Biol Chem 2000
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Catalyst Activity

15-hydroxyprostaglandin dehydrogenase (NAD+) activity of HPGD dimer [cytosol]

Physical Entity
HPGD dimer [cytosol] (Homo sapiens)
Activity
15-hydroxyprostaglandin dehydrogenase (NAD+) activity (GO:0016404)
Orthologous Events
LXA4 is oxidised to 15k-LXA4 by HPGD (Bos taurus)
LXA4 is oxidised to 15k-LXA4 by HPGD (Canis familiaris)
LXA4 is oxidised to 15k-LXA4 by HPGD (Danio rerio)
LXA4 is oxidised to 15k-LXA4 by HPGD (Drosophila melanogaster)
LXA4 is oxidised to 15k-LXA4 by HPGD (Gallus gallus)
LXA4 is oxidised to 15k-LXA4 by HPGD (Mus musculus)
LXA4 is oxidised to 15k-LXA4 by HPGD (Rattus norvegicus)
LXA4 is oxidised to 15k-LXA4 by HPGD (Sus scrofa)
LXA4 is oxidised to 15k-LXA4 by HPGD (Xenopus tropicalis)
Cross References
RHEA
Rhea
Authored
Williams, MG  (2012-02-24)
Reviewed
Hansen, TV  (2018-02-21)
Rush, MG  (2012-11-10)
Created
Williams, MG  (2012-03-14)
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