LXA4 is oxidised to 15k-LXA4 by HPGD

Stable Identifier
R-HSA-2161779
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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15-Hydroxyprostaglandin dehydrogenase (HPGD) converts lipoxin A4 (LXA4) to 15-oxo lipoxin A4 aka 15-keto-LXA4 (15k-LXA4) (Clish et al. 2000).
Literature References
PubMed ID Title Journal Year
10837478 Oxidoreductases in lipoxin A4 metabolic inactivation: a novel role for 15-oxoprostaglandin 13-reductase/leukotriene B4 12-hydroxydehydrogenase in inflammation

Tai, HH, Serhan, CN, Clish, CB, Chiang, N, Levy, BD

J Biol Chem 2000
Participants
Participates
Catalyst Activity

15-hydroxyprostaglandin dehydrogenase (NAD+) activity of HPGD dimer [cytosol]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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