15S-HETE is oxidised to 15-oxoETE by 15-HEDH

Stable Identifier
R-HSA-2161789
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + NAD(P)(+) = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NAD(P)H
ReviewStatus
5/5
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15S-HETE is oxidised to 15-oxoETE by 15-HEDH
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A 15-hydroxy-eicosatetraenoic acid dehydrogenase (15-HEDH) oxidises 15S-hydroxyeicosatetraenoic acid (15S-HETE) to 15-oxo-eicosatetraenoic acid (15-oxoETE) (Gulliksson et al. 2007). The actual human 15-HEDH has yet to be cloned.
Literature References
PubMed ID Title Journal Year
17662651 Expression of 15-lipoxygenase type-1 in human mast cells

Gulliksson, M, Brunnström, A, Johannesson, M, Backman, L, Nilsson, G, Harvima, I, Dahlén, B, Kumlin, M, Claesson, HE

Biochim Biophys Acta 2007
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Catalyst Activity

15-hydroxyicosatetraenoate dehydrogenase activity of 15-HEDH [cytosol]

Physical Entity
15-HEDH [cytosol] (Homo sapiens)
Activity
15-hydroxyicosatetraenoate dehydrogenase activity (GO:0047034)
Cross References
RHEA
Authored
Williams, MG  (2012-02-24)
Reviewed
Rush, MG  (2012-11-10)
Created
Williams, MG  (2012-03-14)
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