EXD4 is converted to EXE4 by DPEP

Stable Identifier
R-HSA-2161868
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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EXD4 is converted to EXE4 by DPEP
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In an analogous reaction to the formation of leukotriene E4 (LTE4), eoxin D4 (EXD4) is converted to eoxin E4 (EXE4) by a dipeptidase (DPEP) (Feltenmark et al. 2008, Claesson et al. 2008) which has not yet been identified.
Literature References
PubMed ID Title Journal Year
18184802 Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human eosinophils and mast cells

Griffiths, W, Brunnström, A, Edenius, C, Backman, L, Björkholm, M, Gautam, N, Lindbom, L, Claesson, HE, Feltenmark, S

Proc Natl Acad Sci U S A 2008
18647347 Hodgkin Reed-Sternberg cells express 15-lipoxygenase-1 and are putative producers of eoxins in vivo: novel insight into the inflammatory features of classical Hodgkin lymphoma

Brunnström, A, Björkholm, M, Johnson, HA, Griffiths, WJ, Sjöberg, J, Porwit, A, Claesson, HE, Schain, F, Feltenmark, S, Andersson, E

FEBS J 2008
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Output
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Catalyst Activity

eoxin E4 synthase activity of DPEP [cytosol]

Physical Entity
DPEP [cytosol] (Homo sapiens)
Activity
eoxin E4 synthase activity (GO:0097263)
Authored
Williams, MG  (2012-02-24)
Reviewed
Rush, MG  (2012-11-10)
Created
Williams, MG  (2012-03-14)
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