Reactome | 12S-HpETE is reduced to 12S-HETE by GPX1/2/4

12S-HpETE is reduced to 12S-HETE by GPX1/2/4

Stable Identifier

R-HSA-2161999

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

12S-HpETE is reduced to 12S-HETE by GPX1/2/4

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Glutathione peroxidase 1 (GPX1) (Bryant et al. 1982, Sutherland et al. 2001), 2 (GPX2) (Chu et al. 1993), and 4 (Bryant et al. 1982, Sutherland et al. 2001) are involved in converting 12S-hydroperoxy-eicosatetraenoic acid (12S-HpETE) to 12S-hydro-eicosatetraenoic acid (12S-HETE). GPXs are selenoenzymes that are responsible for reducing the cellular peroxide. Cellular GPXs compete with hepoxilins A3 (HXA3) synthase for 12S-HpETE as substrate either to produce 12S-HETE or to convert to HXA3, respectively.

Literature References

PubMed ID	Title	Journal	Year
11115402	Evidence for the presence of phospholipid hydroperoxide glutathione peroxidase in human platelets: implications for its involvement in the regulatory network of the 12-lipoxygenase pathway of arachidonic acid metabolism Schewe, T, Shankaranarayanan, P, Nigam, S, Sutherland, M	Biochem J	2001
6816802	Role of glutathione peroxidase and hexose monophosphate shunt in the platelet lipoxygenase pathway Simon, TC, Bailey, JM, Bryant, RW	J Biol Chem	1982
8428933	Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI Esworthy, RS, Chu, FF, Doroshow, JH	J Biol Chem	1993