carbovir monophosphate + ATP => carbovir diphosphate + ADP

Stable Identifier
R-HSA-2162092
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Phosphorylation of carbovir monophosphate
ReviewStatus
5/5
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carbovir monophosphate + ATP => carbovir diphosphate + ADP
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Cytosolic GUK1 (guanylate kinase 1) catalyzes the reaction of carbovir monophosphate and ATP to form carbovir diphosphate and ADP. The activity of human GUK1 is inferred from that of the corresponding pig protein (Miller et al. 1992).
Literature References
PubMed ID Title Journal Year
1383219 Phosphorylation of carbovir enantiomers by cellular enzymes determines the stereoselectivity of antiviral activity

Miller, WH, Boyd, FL, Miller, RL, Hopkins, S, Garvey, EP, Reardon, JE, Daluge, SM

J Biol Chem 1992
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as an event of
Catalyst Activity

nucleoside monophosphate kinase activity of unknown kinase [cytosol]

Physical Entity
unknown kinase [cytosol] (Homo sapiens)
Activity
nucleoside monophosphate kinase activity (GO:0050145)
Inferred From
carbovir monophosphate + ATP => carbovir diphosphate + ADP (Sus scrofa)
Authored
D'Eustachio, P  (2012-03-14)
Reviewed
Jassal, B  (2012-03-16)
Created
D'Eustachio, P  (2012-03-14)
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