abacavir + UDP-glucuronate => abacavir 5'-glucuronide + UDP

Stable Identifier
R-HSA-2162099
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Glucuronidation of abacavir
ReviewStatus
5/5
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A member of the UDPGT (UDP-glucuronosyltransferase) enzyme family is thought to catalyze the reaction of abacavir and UDP-glucuronate to form UDP and abacavir-5'-glucuronate, one of the major forms in which abacavir is excreted from the body (McDowell et al. 1999; Ravitch and Moseley 2001). The specific UDPGT family enzyme family member or members that catalyze this reaction have not been identified.
Literature References
PubMed ID Title Journal Year
11678376 High-performance liquid chromatographic assay for abacavir and its two major metabolites in human urine and cerebrospinal fluid

Moseley, CG, Ravitch, JR

J Chromatogr B Biomed Sci Appl 2001
10582871 Pharmacokinetics of [(14)C]abacavir, a human immunodeficiency virus type 1 (HIV-1) reverse transcriptase inhibitor, administered in a single oral dose to HIV-1-infected adults: a mass balance study

Ravitch, JR, Chittick, GE, Stein, DS, McDowell, JA, Kerkering, TM, Polk, RE

Antimicrob Agents Chemother 1999
Participants
Participates
Catalyst Activity

glucuronosyltransferase activity of UDPGT [endoplasmic reticulum membrane]

Authored
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