COQ2 ligates all-E-10PrP2 to PHB

Stable Identifier
R-HSA-2162192
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
PHB and all-E-10PrP2 are combined into DHB by COQ2
ReviewStatus
5/5
Locations in the PathwayBrowser
General
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4-Hydroxybenzoate polyprenyltransferase (COQ2) catalyses the combination of 4-hydroxybenzoic acid, aka para-hydroxybenzoic acid (PHB), with the polyisoprenoid tail all-trans-decaprenyl diphosphate (all-E-10PrP2) to form 3-decaprenyl-4-hydroxybenzoate (DHB) (Forsgren et al., 2004; Lopez-Martin ef al., 2007; Tekle et al., 2008).
Literature References
PubMed ID Title Journal Year
17916383 Investigation of coenzyme Q biosynthesis in human fibroblast and HepG2 cells

Dallner, G, Turunen, M, Swiezewska, E, Tekle, M, Chojnacki, T

J Biochem Biophys Methods 2008
17374725 Missense mutation of the COQ2 gene causes defects of bioenergetics and de novo pyrimidine synthesis

Salviati, L, Trevisson, E, Sánchez-Alcázar, JA, DiMauro, S, Rodriguez-Hernandez, A, Hirano, M, Quinzii, C, López-Martín, JM, Navas, P, Santos-Ocaña, C, Cordero, MD, Montini, G

Hum Mol Genet 2007
15153069 Isolation and functional expression of human COQ2, a gene encoding a polyprenyl transferase involved in the synthesis of CoQ

Dallner, G, Climent, I, Grünler, J, Attersand, A, Swiezewska, E, Forsgren, M, Lake, S

Biochem J 2004
Participants
Participates
Catalyst Activity

4-hydroxybenzoate decaprenyltransferase activity of COQ2 [mitochondrial inner membrane]

Orthologous Events
Cross References
Rhea
RHEA
Authored
Reviewed
Created
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