Reactome | Unknown enzyme decarboxylates MHDB

Unknown enzyme decarboxylates MHDB

Stable Identifier

R-HSA-2162195

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

MHDB is decarboxylated to DMPhOH by MHDB decarboxylase

ReviewStatus

4/5

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3-methoxy-4-hydroxy-5-decaprenylbenzoic acid (MHDB) is enzymatically decarboxylated to form 2-methoxy-6-decaprenylphenol (DMPhOH). At the present time the enzyme identity is unknown but is thought to be a member of the COQ family. This reaction is inferred from the equivalent reaction in yeast (Casey & Threlfall 1978, Goewert et al. 1981).

Literature References

PubMed ID	Title	Journal	Year
620805	Synthesis of 5-demethoxyubiquinone-6 and ubiquinone-6 from 3-hexaprenyl-4-hydroxybenzoate in yeast mitochondria Threlfall, DR, Casey, J	FEBS Lett	1978
7028108	Identification of 3-methoxy-4-hydroxy-5-hexaprenylbenzoic acid as a new intermediate in ubiquinone biosynthesis by Saccharomyces cerevisiae Olson, RE, Sippel, CJ, Goewert, RR, Grimm, MF	Biochemistry	1981

Participants

Input

Output

Participates

as an event of

Ubiquinol biosynthesis (Homo sapiens)

Catalyst Activity

3-methoxy-4-hydroxy-5-decaprenylbenzoic acid decarboxylase activity of MHDB decarboxylase [mitochondrial matrix]

Physical Entity

MHDB decarboxylase [mitochondrial matrix] (Homo sapiens)

Activity

3-methoxy-4-hydroxy-5-decaprenylbenzoic acid decarboxylase activity (GO:0036169)

Inferred From

MHHB is decarboxylated to HMPhOH by MHHB decarboxylase (Saccharomyces cerevisiae)

Authored

Williams, MG (2012-03-19)

Reviewed

Kawamukai, M (2013-02-05)

Created

Williams, MG (2012-03-15)

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