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p-T,Y-MAPK8 [nucleoplasm]
Stable Identifier
R-HSA-216349
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
p-T,Y-JNK1, mitogen-activated protein kinase 8 (phosphorylated)
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
Activated JNKs phosphorylate c-JUN (Homo sapiens)
p-MAPK8,9,10 [nucleoplasm] (Homo sapiens)
p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
p-MAPK8,9,10 [nucleoplasm] (Homo sapiens)
p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
DNA Double Strand Break Response (Homo sapiens)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Homo sapiens)
APBB1 and MAPK8 bind diphosphorylated H2AFX (Homo sapiens)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome:APBB1:p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by ALK in cancer (Homo sapiens)
Signaling by ALK fusions and activated point mutants (Homo sapiens)
JNK-dependent inhibition of TP53 ubiquitination (Homo sapiens)
p-T,Y MAPK8,9:TP53 tetramer [nucleoplasm] (Homo sapiens)
p-T,Y MAPK8,9 [nucleoplasm] (Homo sapiens)
p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
NPM1-ALK- and JNK-dependent JUN phosphorylation (Homo sapiens)
p-T,Y MAPK8,9 [nucleoplasm] (Homo sapiens)
p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
p-T,Y MAPK8,9 bind TP53 (Homo sapiens)
p-T,Y MAPK8,9 [nucleoplasm] (Homo sapiens)
p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
p-T,Y MAPK8,9:TP53 tetramer [nucleoplasm] (Homo sapiens)
p-T,Y MAPK8,9 [nucleoplasm] (Homo sapiens)
p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
p-T,Y MAPK8,9 translocate to the nucleus (Homo sapiens)
p-T,Y MAPK8,9 [nucleoplasm] (Homo sapiens)
p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Killing mechanisms (Homo sapiens)
WNT5:FZD7-mediated leishmania damping (Homo sapiens)
Activated JNK phosphorylates c-JUN (Homo sapiens)
p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
p-T,Y-MAPK8 translocates from the cytosol to the nucleoplasm (Homo sapiens)
p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-17 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
p-MAPK8,9,10 [nucleoplasm] (Homo sapiens)
p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
Activation of the AP-1 family of transcription factors (Homo sapiens)
Activated JNKs phosphorylate c-JUN (Homo sapiens)
p-MAPK8,9,10 [nucleoplasm] (Homo sapiens)
p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
Phosphorylated MAPKs phosphorylate ATF-2 (Homo sapiens)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Homo sapiens)
p-MAPK8,9,10 [nucleoplasm] (Homo sapiens)
p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
Innate Immune System (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated MAPK activation (Homo sapiens)
Activated JNKs phosphorylate c-JUN (Homo sapiens)
p-MAPK8,9,10 [nucleoplasm] (Homo sapiens)
p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
p-MAPK8,9,10 [nucleoplasm] (Homo sapiens)
p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
p-MAPK8,9,10 [nucleoplasm] (Homo sapiens)
p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
Activation of the AP-1 family of transcription factors (Homo sapiens)
Activated JNKs phosphorylate c-JUN (Homo sapiens)
p-MAPK8,9,10 [nucleoplasm] (Homo sapiens)
p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
Phosphorylated MAPKs phosphorylate ATF-2 (Homo sapiens)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Homo sapiens)
p-MAPK8,9,10 [nucleoplasm] (Homo sapiens)
p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
p-MAPK8,9,10 [nucleoplasm] (Homo sapiens)
p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
Activation of the AP-1 family of transcription factors (Homo sapiens)
Activated JNKs phosphorylate c-JUN (Homo sapiens)
p-MAPK8,9,10 [nucleoplasm] (Homo sapiens)
p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
Phosphorylated MAPKs phosphorylate ATF-2 (Homo sapiens)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Homo sapiens)
p-MAPK8,9,10 [nucleoplasm] (Homo sapiens)
p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
p-MAPK8,9,10 [nucleoplasm] (Homo sapiens)
p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
Activation of the AP-1 family of transcription factors (Homo sapiens)
Activated JNKs phosphorylate c-JUN (Homo sapiens)
p-MAPK8,9,10 [nucleoplasm] (Homo sapiens)
p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
Phosphorylated MAPKs phosphorylate ATF-2 (Homo sapiens)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Homo sapiens)
p-MAPK8,9,10 [nucleoplasm] (Homo sapiens)
p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
p-MAPK8,9,10 [nucleoplasm] (Homo sapiens)
p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
Activation of the AP-1 family of transcription factors (Homo sapiens)
Activated JNKs phosphorylate c-JUN (Homo sapiens)
p-MAPK8,9,10 [nucleoplasm] (Homo sapiens)
p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
Phosphorylated MAPKs phosphorylate ATF-2 (Homo sapiens)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Homo sapiens)
p-MAPK8,9,10 [nucleoplasm] (Homo sapiens)
p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
p-MAPK8,9,10 [nucleoplasm] (Homo sapiens)
p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
Activation of the AP-1 family of transcription factors (Homo sapiens)
Activated JNKs phosphorylate c-JUN (Homo sapiens)
p-MAPK8,9,10 [nucleoplasm] (Homo sapiens)
p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
Phosphorylated MAPKs phosphorylate ATF-2 (Homo sapiens)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Homo sapiens)
p-MAPK8,9,10 [nucleoplasm] (Homo sapiens)
p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
p-MAPK8,9,10 [nucleoplasm] (Homo sapiens)
p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
Activation of the AP-1 family of transcription factors (Homo sapiens)
Activated JNKs phosphorylate c-JUN (Homo sapiens)
p-MAPK8,9,10 [nucleoplasm] (Homo sapiens)
p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
Phosphorylated MAPKs phosphorylate ATF-2 (Homo sapiens)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Homo sapiens)
p-MAPK8,9,10 [nucleoplasm] (Homo sapiens)
p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
p-MAPK8,9,10 [nucleoplasm] (Homo sapiens)
p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
Activation of the AP-1 family of transcription factors (Homo sapiens)
Activated JNKs phosphorylate c-JUN (Homo sapiens)
p-MAPK8,9,10 [nucleoplasm] (Homo sapiens)
p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
Phosphorylated MAPKs phosphorylate ATF-2 (Homo sapiens)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Homo sapiens)
p-MAPK8,9,10 [nucleoplasm] (Homo sapiens)
p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
p-MAPK8,9,10 [nucleoplasm] (Homo sapiens)
p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
Activation of the AP-1 family of transcription factors (Homo sapiens)
Activated JNKs phosphorylate c-JUN (Homo sapiens)
p-MAPK8,9,10 [nucleoplasm] (Homo sapiens)
p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
Phosphorylated MAPKs phosphorylate ATF-2 (Homo sapiens)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Homo sapiens)
p-MAPK8,9,10 [nucleoplasm] (Homo sapiens)
p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
p-MAPK8,9,10 [nucleoplasm] (Homo sapiens)
p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
Activation of the AP-1 family of transcription factors (Homo sapiens)
Activated JNKs phosphorylate c-JUN (Homo sapiens)
p-MAPK8,9,10 [nucleoplasm] (Homo sapiens)
p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
Phosphorylated MAPKs phosphorylate ATF-2 (Homo sapiens)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Homo sapiens)
p-MAPK8,9,10 [nucleoplasm] (Homo sapiens)
p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
NRAGE signals death through JNK (Homo sapiens)
Active JNK moves to the nucleus and phosphorylates different transcription factors (Homo sapiens)
p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P45983 MAPK8
Gene Names
MAPK8, JNK1, PRKM8, SAPK1, SAPK1C
Chain
chain:1-427
Reference Genes
BioGPS Gene:5599 MAPK8
COSMIC (genes):MAPK8 MAPK8
CTD Gene:5599 MAPK8
dbSNP Gene:5599 MAPK8
ENSEMBL:ENSG00000107643 MAPK8
ENSEMBL_homo_sapiens_GENE:ENSG00000107643.17 MAPK8
HGNC:6881 MAPK8
KEGG Gene (Homo sapiens):5599 MAPK8
Monarch:5599 MAPK8
NCBI Gene:5599 MAPK8
OMIM:601158 MAPK8
UCSC:P45983 MAPK8
Reference Transcript
RefSeq:NM_001323328.1 MAPK8
RefSeq:NM_001323322.1 MAPK8
RefSeq:NM_001323327.1 MAPK8
RefSeq:NM_139049.3 MAPK8
RefSeq:NM_001323321.1 MAPK8
RefSeq:NM_001323326.1 MAPK8
RefSeq:NM_139046.3 MAPK8
RefSeq:NM_001323331.1 MAPK8
RefSeq:NM_001323325.1 MAPK8
RefSeq:NM_001323302.1 MAPK8
RefSeq:NM_001278548.1 MAPK8
RefSeq:NM_001323330.1 MAPK8
RefSeq:NM_001323324.1 MAPK8
RefSeq:NM_001323329.1 MAPK8
RefSeq:NM_001278547.1 MAPK8
RefSeq:NM_001323323.1 MAPK8
Other Identifiers
11736292_a_at
11747477_a_at
11759192_a_at
16704687
2070_i_at
2071_s_at
210477_PM_x_at
210477_x_at
210671_PM_x_at
210671_x_at
226046_PM_at
226046_at
226048_PM_at
226048_at
229664_PM_at
229664_at
3245685
3245686
3245690
3245693
3245701
3245713
3245714
3245715
3245717
3245718
3245720
3245721
3245723
3245724
3245728
3245731
3245732
3245735
3245739
3245740
3245741
3245742
3245743
3245744
34006_s_at
47790_at
49510_at
49512_at
5599
56901_at
7927389
A_14_P128899
A_23_P202540
A_23_P356152
A_24_P286898
A_33_P3250289
GE57700
GO:0000165
GO:0000166
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0004705
GO:0004707
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006468
GO:0006914
GO:0006979
GO:0007254
GO:0007258
GO:0009411
GO:0009612
GO:0010628
GO:0012501
GO:0016241
GO:0016301
GO:0016310
GO:0016740
GO:0018105
GO:0018107
GO:0019899
GO:0019903
GO:0023052
GO:0030424
GO:0031281
GO:0031343
GO:0032091
GO:0032880
GO:0033554
GO:0034198
GO:0034599
GO:0034614
GO:0035033
GO:0036211
GO:0038095
GO:0042752
GO:0042826
GO:0043065
GO:0043066
GO:0043226
GO:0045202
GO:0048511
GO:0051247
GO:0051403
GO:0065003
GO:0071222
GO:0071260
GO:0071276
GO:0090398
GO:0097441
GO:0098772
GO:0106310
GO:0120283
GO:0140096
GO:1900227
HMNXSV003013434
Hs.267445.0.S1_3p_at
Hs.267445.0.S2_3p_at
Hs.65228.0.A1_3p_at
ILMN_1849941
ILMN_2308806
ILMN_2364574
PH_hs_0026061
PH_hs_0039294
TC10000322.hg
TC10002063.hg
U35005_s_at
g1463136_3p_a_at
g1463136_3p_s_at
Participates
as a member of
p-T,Y MAPK8,9 [nucleoplasm] (Homo sapiens)
p-MAPK8,9,10 [nucleoplasm] (Homo sapiens)
as an output of
p-T,Y-MAPK8 translocates from the cytosol to the nucleoplasm (Homo sapiens)
Active JNK moves to the nucleus and phosphorylates different transcription factors (Homo sapiens)
as a component of
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome:APBB1:p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
as an input of
APBB1 and MAPK8 bind diphosphorylated H2AFX (Homo sapiens)
Other forms of this molecule
MAPK8 [cytosol]
p-T,Y-MAPK8 [cytosol]
Inferred To
phospho-MAPK8 [nucleoplasm]
(Bos taurus)
phospho-MAPK8 [nucleoplasm]
(Canis familiaris)
phospho-MAPK8 [nucleoplasm]
(Gallus gallus)
phospho-MAPK8 [nucleoplasm]
(Sus scrofa)
Homologues of p-T,Y-MAPK8 [nucleoplasm]
(Dictyostelium discoideum)
phospho-p-T,Y-MAPK8 [nucleoplasm]
(Caenorhabditis elegans)
phospho-p-T,Y-MAPK8 [nucleoplasm]
(Danio rerio)
phospho-p-T,Y-MAPK8 [nucleoplasm]
(Dictyostelium discoideum)
phospho-p-T,Y-MAPK8 [nucleoplasm]
(Drosophila melanogaster)
phospho-p-T,Y-MAPK8 [nucleoplasm]
(Mus musculus)
phospho-p-T,Y-MAPK8 [nucleoplasm]
(Rattus norvegicus)
phospho-p-T,Y-MAPK8 [nucleoplasm]
(Saccharomyces cerevisiae)
phospho-p-T,Y-MAPK8 [nucleoplasm]
(Schizosaccharomyces pombe)
Modified Residues
Name
O-phospho-L-threonine at unknown position
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_001310255.1
,
NP_001310256.1
,
NP_001310250.1
,
NP_001310260.1
,
NP_001310252.1
,
NP_001310259.1
,
NP_620634.1
,
NP_001310251.1
,
NP_620637.1
,
NP_001310253.1
,
NP_001310258.1
,
NP_001265477.1
,
NP_001310231.1
,
NP_001310254.1
,
NP_001310257.1
,
NP_001265476.1
ZINC - World Drugs
MK08_HUMAN
Guide to Pharmacology - Targets
1496
OpenTargets
ENSG00000107643
ZINC - FDA approved
MK08_HUMAN
ZINC - Substances
MK08_HUMAN
ZINC target
P45983
ZINC - Biogenic
MK08_HUMAN
PRO
P45983
PDB
3ELJ
,
4G1W
,
3VUD
,
8X5M
,
1UKH
,
2G01
,
4AWI
,
3O17
,
6ZR5
,
3VUM
,
2XRW
,
2XS0
,
3O2M
,
2GMX
,
3V3V
,
2H96
,
3VUL
,
6F5E
,
2NO3
,
4YR8
,
3VUK
,
4HYU
,
4HYS
,
4QTD
,
4UX9
,
3VUI
,
4E73
,
3VUH
,
5LW1
,
3PZE
,
4L7F
,
4IZY
,
3VUG
,
1UKI
ZINC - Investigational
MK08_HUMAN
HPA
ENSG00000107643-MAPK8
GeneCards
P45983
Ensembl
ENSP00000363291
,
ENST00000395611
,
ENSP00000363294
,
ENSP00000363297
,
ENST00000374179
,
ENSP00000378974
,
ENSP00000353483
,
ENST00000374189
,
ENST00000374176
,
ENST00000360332
,
ENSP00000363304
,
ENST00000374182
,
ENSG00000107643
Pharos - Targets
P45983
ZINC - Predictions - Purchasable
MK08_HUMAN
HMDB Protein
HMDBP01536
Interactors (18)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05412 JUN
4
p-S63,S73-JUN [cytosol]
(R-HSA-8868682)
JUN [nucleoplasm]
(R-HSA-450250)
p-S63,S73-JUN [nucleoplasm]
(R-HSA-450237)
JUN [cytosol]
(R-HSA-168194)
0.854
5
UniProt:P45984 MAPK9
3
MAPK9 [cytosol]
(R-HSA-450355)
p-T183,Y185-MAPK9 [cytosol]
(R-HSA-450293)
p-T183,Y185-MAPK9 [nucleoplasm]
(R-HSA-450319)
0.773
5
UniProt:Q9UQF2 JIP1
0.708
8
UniProt:P45985 MAP2K4
4
MAP2K4 [cytosol]
(R-HSA-168107)
p-S257,T261-MAP2K4 [cytosol]
(R-HSA-168170)
MAP2K4(1-?) [cytosol]
(R-HSA-5211402)
MAP2K4(?-399) [cytosol]
(R-HSA-5211396)
0.688
3
UniProt:Q13202 DUSP8
2
DUSP8 [nucleoplasm]
(R-HSA-5675349)
DUSP8 [cytosol]
(R-HSA-5675348)
0.659
3
UniProt:O43379 WDR62
0.643
3
UniProt:P27986 PIK3R1
16
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 [cytosol]
(R-HSA-74789)
PIK3R1 [plasma membrane]
(R-HSA-198365)
0.623
6
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.553
2
UniProt:O14733-2 MAP2K7
0.544
3
UniProt:P46108 CRK
1
CRK [cytosol]
(R-HSA-2980677)
0.536
2
UniProt:P29401 TKT
1
TKT [cytosol]
(R-HSA-71321)
0.527
2
UniProt:P16104 H2AFX
7
Me2sR4-H2AFX [nucleoplasm]
(R-HSA-5218317)
H2AFX [nucleoplasm]
(R-HSA-56151)
p-Y143-H2AFX [nucleoplasm]
(R-HSA-5683942)
p-S140,Y143-H2AFX [nucleoplasm]
(R-HSA-5683953)
p-S140-H2AFX [nucleoplasm]
(R-HSA-75170)
K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm]
(R-HSA-5682847)
H2AFX [extracellular region]
(R-HSA-977583)
0.524
3
UniProt:Q07817 BCL2L1
2
BCL2L1 [cytosol]
(R-HSA-50771)
BCL2L1 [mitochondrial outer membrane]
(R-HSA-114236)
0.516
2
UniProt:Q8N122 RPTOR
3
RPTOR [nucleoplasm]
(R-HSA-5083664)
RPTOR [cytosol]
(R-HSA-3006727)
p-S722,S792-RPTOR [cytosol]
(R-HSA-3132767)
0.499
6
UniProt:Q9WVI9-1 MAPK8IP1
0.499
2
UniProt:P56747 CLDN6
2
CLDN6 [plasma membrane]
(R-HSA-419992)
CLDN6 [cell junction]
(R-HSA-421250)
0.488
3
UniProt:O14733 MAP2K7
4
MAP2K7(?-419) [cytosol]
(R-HSA-5211401)
MAP2K7(2-?) [cytosol]
(R-HSA-5211389)
MAP2K7 [cytosol]
(R-HSA-450276)
p-S271,T275-MAP2K7 [cytosol]
(R-HSA-450353)
0.483
4
UniProt:P60953 CDC42
3
CDC42 [endoplasmic reticulum membrane]
(R-HSA-5672086)
CDC42 [cytosol]
(R-HSA-442630)
CDC42 [plasma membrane]
(R-HSA-449545)
0.483
2
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