SMAD7:SMURF2 complex translocates to the cytosol

Stable Identifier
R-HSA-2167876
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SMAD7:SMURF2 complex translocates to the cytosol
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
After forming a complex in the nucleus, SMAD7:SMURF2 traffics to the cytosol (Kavsak et al. 2000). This was inferred from experiments that used a recombinant mouse Smad7 and recombinant human SMURF2.
Literature References
PubMed ID Title Journal Year
11163210 Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

Thomsen, GH, Wrana, JL, Bonni, S, Causing, CG, Rasmussen, RK, Zhu, H, Kavsak, P

Mol Cell 2000
Participants
Input
Output
Participates
as an event of
Inferred From
Smad7:SMURF2 complex translocates to the cytosol (Homo sapiens)
Authored
Orlic-Milacic, M  (2012-04-05)
Reviewed
Huang, T  (2012-05-14)
Created
Orlic-Milacic, M  (2012-03-23)
Cite Us!