Reactome | USO1 [Golgi membrane]

USO1 [Golgi membrane]

Stable Identifier

R-HSA-2167936

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

Synonyms

General vesicular transport factor p115, TAP

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPI-mediated anterograde transport (Homo sapiens)
        
        COPI vesicle uncoating (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1 [Golgi membrane] (Homo sapiens)
        
        USO1 homodimer [Golgi membrane] (Homo sapiens)
        
        USO1 [Golgi membrane] (Homo sapiens)
        
        Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1 [Golgi membrane] (Homo sapiens)
        
        USO1 homodimer [Golgi membrane] (Homo sapiens)
        
        USO1 [Golgi membrane] (Homo sapiens)
        
        cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1 [Golgi membrane] (Homo sapiens)
        
        USO1 homodimer [Golgi membrane] (Homo sapiens)
        
        USO1 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1 [Golgi membrane] (Homo sapiens)
        
        USO1 homodimer [Golgi membrane] (Homo sapiens)
        
        USO1 [Golgi membrane] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPI-mediated anterograde transport (Homo sapiens)
      - COPI vesicle uncoating (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1 [Golgi membrane] (Homo sapiens)
        
        USO1 homodimer [Golgi membrane] (Homo sapiens)
        
        USO1 [Golgi membrane] (Homo sapiens)
      - Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1 [Golgi membrane] (Homo sapiens)
        
        USO1 homodimer [Golgi membrane] (Homo sapiens)
        
        USO1 [Golgi membrane] (Homo sapiens)
      - cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1 [Golgi membrane] (Homo sapiens)
        
        USO1 homodimer [Golgi membrane] (Homo sapiens)
        
        USO1 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1 [Golgi membrane] (Homo sapiens)
        
        USO1 homodimer [Golgi membrane] (Homo sapiens)
        
        USO1 [Golgi membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O60763 USO1

Gene Names

USO1, VDP

Chain

chain:1-962

Reference Genes

BioGPS Gene:8615 USO1

COSMIC (genes):USO1 USO1

CTD Gene:8615 USO1

dbSNP Gene:8615 USO1

ENSEMBL:ENSG00000138768 USO1

HGNC:30904 USO1

KEGG:hsa:8615 USO1

Monarch:8615 USO1

NCBI Gene:8615 USO1

OMIM:603344 USO1

UCSC:O60763 USO1

Reference Transcript

Other Identifiers

11716440_s_at

11716441_at

16967925

201831_PM_s_at

201831_s_at

201832_PM_s_at

201832_s_at

2731830

2731832

2731833

2731842

2731847

2731848

2731849

2731850

2731851

2731852

2731855

2731857

2731860

2731867

2731869

2731871

2731872

2731873

2731874

2731875

2731876

2731877

2731878

2731879

2731881

2731882

2731883

2731884

2743190

37356_r_at

45396_at

8095773

8615

A_23_P29855

GO:0000139

GO:0001650

GO:0003723

GO:0005515

GO:0005737

GO:0005783

GO:0005794

GO:0005795

GO:0005815

GO:0005829

GO:0006886

GO:0006888

GO:0007030

GO:0007264

GO:0012507

GO:0015031

GO:0016020

GO:0016192

GO:0030133

GO:0031410

GO:0032252

GO:0043226

GO:0045056

GO:0045296

GO:0048211

GO:0048280

GO:0048471

GO:0061024

GO:0061025

GO:1900076

HMNXSV003009152

Hs.325948.0.A1_3p_a_at

ILMN_1692121

PH_hs_0016169

TC04000421.hg

g4505540_3p_a_at

Participates

as a component of

USO1 homodimer [Golgi membrane] (Homo sapiens)

Other forms of this molecule

USO1 [transport vesicle]

USO1 [ER to Golgi transport vesicle membrane]

USO1 [microtubule organizing center]

USO1 [cytosol]

Inferred To

Uso1 [Golgi membrane] (Mus musculus)

Uso1 [Golgi membrane] (Rattus norvegicus)

uso-1 [Golgi membrane] (Caenorhabditis elegans)

uso1 [Golgi membrane] (Schizosaccharomyces pombe)

USO1 [Golgi membrane] (Bos taurus)

USO1 [Golgi membrane] (Canis familiaris)

USO1 [Golgi membrane] (Dictyostelium discoideum)

USO1 [Golgi membrane] (Gallus gallus)

USO1 [Golgi membrane] (Sus scrofa)

p115 [Golgi membrane] (Drosophila melanogaster)

Ghost homologue of USO1 [Golgi membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001276978.1, NP_003706.2

ENSEMBL

ENSP00000444850, ENST00000514213, ENSP00000264904, ENST00000264904

OpenTargets

ENSG00000138768

HPA

ENSG00000138768-USO1

PRO

O60763

Pharos - Targets

O60763

GlyGen

O60763

PDB

2W3C

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.601	4
UniProt:Q8NE22 SETD9	1	SETD9 [nucleoplasm] (R-HSA-3239029)	0.499	2

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