Reactome | Tropocollagen type VIII [extracellular region]

Tropocollagen type VIII [extracellular region]

Stable Identifier

R-HSA-2168043

Type

Complex

Species

Homo sapiens

Compartment

extracellular region

Locations in the PathwayBrowser

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General

Collagen type VIII (COL8) is a major component of Descemet’s membrane. It is suggested that the form found in Decemet's membrane is composed of a 2:1 ratio of alpha-1(VIII) and alpha-2 (VIII). In vitro both can also form homotrimers (Knupp & Squire 2005).

Participants

components

x 2 Collagen alpha-1(VIII) chains [extracellular region] (Homo sapiens)
Collagen alpha-2(VIII) chains [extracellular region] (Homo sapiens)

Participates

as a member of

Non-fibrillar collagens [extracellular region] (Homo sapiens)
Network forming tropocollagens [extracellular region] (Homo sapiens)

as a repeated unit of

Collagen type VIII network [extracellular region] (Homo sapiens)
Collagen type VIII fibril [extracellular region] (Homo sapiens)

Inferred To

Tropocollagen type VIII [extracellular region] (Bos taurus)

Tropocollagen type VIII [extracellular region] (Canis familiaris)

Tropocollagen type VIII [extracellular region] (Danio rerio)

Tropocollagen type VIII [extracellular region] (Gallus gallus)

Tropocollagen type VIII [extracellular region] (Mus musculus)

Tropocollagen type VIII [extracellular region] (Rattus norvegicus)

Tropocollagen type VIII [extracellular region] (Sus scrofa)