Reactome | 7xHC-HP(19-160) [extracellular region]

7xHC-HP(19-160) [extracellular region]

Stable Identifier

R-HSA-2168848

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

HP alpha chain, Haptoglobin alpha chain, HPT_HUMAN, HP

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P00738 HP

Gene Names

Chain

signal peptide:1-18, chain:19-406, chain:19-160, chain:162-406

Reference Genes

BioGPS Gene:3240 HP

COSMIC (genes):HP HP

CTD Gene:3240 HP

dbSNP Gene:3240 HP

ENSEMBL:ENSG00000257017 HP

HGNC:5141 HP

KEGG:hsa:3240 HP

Monarch:3240 HP

NCBI Gene:3240 HP

OMIM:140100 HP

UCSC:P00738 HP

Reference Transcript

Other Identifiers

11733829_x_at

11744649_x_at

11757277_x_at

16820937

206697_3p_s_at

206697_PM_s_at

206697_s_at

208470_PM_s_at

208470_s_at

3240

3667859

3667860

3667861

3667862

3667863

3667864

3667865

3667866

3667867

3667868

3667869

3667870

3667871

3667872

3667873

3667874

3667875

3667876

3667877

3667878

3667879

3667880

3667881

3667882

3667883

3667884

3667885

3667895

3667899

36983_f_at

36984_f_at

7997188

A_14_P112792

A_23_P206760

A_33_P3289236

GE59631

GE84988

GO:0002376

GO:0003824

GO:0004252

GO:0005515

GO:0005576

GO:0005615

GO:0006508

GO:0006952

GO:0006953

GO:0006954

GO:0016209

GO:0016787

GO:0030492

GO:0031838

GO:0035580

GO:0042542

GO:0042742

GO:0043226

GO:0051354

GO:0070062

GO:0071682

GO:0072562

GO:0098542

GO:0098754

GO:0098869

GO:0140096

GO:1904724

GO:2000296

HMNXSV003047722

Hs2Affx.1.389.S1_3p_s_at

ILMN_1812433

K03431_cds1_at

M69197_xpt2_s_at

PH_hs_0030034

PH_hs_0039997

TC16002057.hg

g4826761_3p_s_at

g4826761_3p_x_at

Participates

as a component of

Haptoglobin [extracellular region] (Homo sapiens)

Other forms of this molecule

HP [specific granule lumen]

HP [extracellular region]

HP [tertiary granule lumen]

5xHC-HP(162-406) [extracellular region]

7xHC-HP(19-160) [endocytic vesicle lumen]

5xHC-HP(162-406) [endocytic vesicle lumen]

Inferred To

Ghost homologue of 7xHC-HP(19-160) [extracellular region] (Bos taurus)

Ghost homologue of 7xHC-HP(19-160) [extracellular region] (Canis familiaris)

c1s.2 [extracellular region] (Danio rerio)

Homologues of 7xHC-HP(19-160) [extracellular region] (Sus scrofa)

HP [extracellular region] (Sus scrofa)

Hp [extracellular region] (Mus musculus)

Hp [extracellular region] (Rattus norvegicus)

7xHC-HP(19-160) [extracellular region] (Gallus gallus)

7xHC-HP(19-160) [extracellular region] (Sus scrofa)

Modified Residues

Name

Intra-chain Crosslink via L-cystine (cross-link) at 52 and 86

Coordinate

PsiMod Name

L-cystine (cross-link)

PsiMod Definition

A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.

Name

Intra-chain Crosslink via L-cystine (cross-link) at 111 and 145

Coordinate

111

PsiMod Name

L-cystine (cross-link)

PsiMod Definition

A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.

Name

Inter-chain Crosslink via L-cystine (cross-link) at 149 and 266

Coordinate

149

PsiMod Name

L-cystine (cross-link)

PsiMod Definition

A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.

Cross References

OpenTargets

ENSG00000257017

ENSEMBL

ENST00000355906, ENSP00000348170, ENSP00000457629, ENST00000570083, ENSP00000381199, ENST00000398131

HPA

ENSG00000257017-HP

PRO

P00738

Pharos - Targets

P00738

GlyGen

P00738

HMDB Protein

HMDBP02380

PDB

5HU6, 4WJG, 4X0L, 6TB2

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02649 APOE	10	APOE [endoplasmic reticulum lumen] (R-HSA-6784908) p-APOE [endoplasmic reticulum lumen] (R-HSA-8956980) APOE [extracellular region] (R-HSA-174646) APOE [endocytic vesicle lumen] (R-HSA-3221641) APOE-4 [extracellular region] (R-HSA-9711070) APOE [plasma membrane] (R-HSA-174615) APOE [clathrin-coated endocytic vesicle membrane] (R-HSA-174651) APOE [endosome membrane] (R-HSA-174766) APOE [endosome lumen] (R-HSA-174804) APOE [early endosome] (R-HSA-2429687)	0.675	7
UniProt:P02647 APOA1	11	APOA1(25-266) [extracellular region] (R-HSA-174720) APOA1 [endoplasmic reticulum lumen] (R-HSA-8956724) p-APOA1 [endoplasmic reticulum lumen] (R-HSA-8957081) APOA1(25-266) [endocytic vesicle lumen] (R-HSA-2239460) Variant apolipoprotein AI [extracellular region] (R-HSA-976865) APOA1(25-266) [plasma membrane] (R-HSA-216742) APOA1(19-266) [extracellular region] (R-HSA-264771) APOA1(25-267) [endoplasmic reticulum lumen] (R-HSA-174640) APOA1(25-267) [early endosome] (R-HSA-2429641) APOA1(25-267) [cytosol] (R-HSA-2395781) APOA1(25-266) [secretory granule lumen] (R-HSA-350761)	0.558	3
UniProt:Q16659 MAPK6 gene	6	p-3S,T MAPK6 [nucleoplasm] (R-HSA-5692665) MAPK6 [nucleoplasm] (R-HSA-5692686) p-S189 MAPK6 [nucleoplasm] (R-HSA-5687015) p-S189 MAPK6 [cytosol] (R-HSA-5687019) MAPK6 [cytosol] (R-HSA-5686979) ub-MAPK6 [cytosol] (R-HSA-5687000)	0.527	2