Reactome | RAD51D [nucleoplasm]

RAD51D [nucleoplasm]

Stable Identifier

R-HSA-216920

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

DNA repair protein RAD51 homolog 4, (R51H4) (RAD51-like protein 3) (TRAD), RAD51L3, R51H4, RAD51D

Locations in the PathwayBrowser for interactor UniProt:Q96N21 AP4AT

Expand all

DNA Repair (Homo sapiens)

- DNA Double-Strand Break Repair (Homo sapiens)
  - Homology Directed Repair (Homo sapiens)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
      - HDR through Homologous Recombination (HRR) (Homo sapiens)
        
        Homologous DNA Pairing and Strand Exchange (Homo sapiens)
        
        Presynaptic phase of homologous DNA pairing and strand exchange (Homo sapiens)
        
        BCDX2 complex formation (Homo sapiens)
        
        RAD51D [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O75771 RAD51D

Gene Names

RAD51D, RAD51L3

Chain

chain:1-328

Reference Genes

BioGPS Gene:5892 RAD51D

COSMIC (genes):RAD51D RAD51D

CTD Gene:5892 RAD51D

dbSNP Gene:5892 RAD51D

ENSEMBL:ENSG00000185379 RAD51D

ENSEMBL_homo_sapiens_GENE:ENSG00000185379.21 RAD51D

HGNC:9823 RAD51D

KEGG Gene (Homo sapiens):5892 RAD51D

Monarch:5892 RAD51D

NCBI Gene:5892 RAD51D

OMIM:602954 RAD51D

UCSC:O75771 RAD51D

Reference Transcript

Other Identifiers

11732399_a_at

11751485_a_at

11758494_s_at

16843374

209965_PM_s_at

209965_s_at

3056509

3753405

3753406

3753407

3753408

3753414

3753415

3753416

3753417

3753418

3753419

3753420

3753421

3753422

3753423

3753424

3753425

3753426

3753427

3753428

3753432

3753433

3753434

3753435

3753436

3753437

3753438

3753439

3753440

3753441

3753442

37792_s_at

37793_PM_r_at

37793_r_at

5892

59538_at

8014199

A_23_P500873

A_24_P356509

A_24_P40827

A_32_P120726

A_33_P3210827

GE56475

GE833404

GE856017

GO:0000166

GO:0000400

GO:0000722

GO:0000723

GO:0000724

GO:0000781

GO:0003677

GO:0003697

GO:0003824

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005657

GO:0005694

GO:0005737

GO:0005813

GO:0005815

GO:0005856

GO:0006259

GO:0006281

GO:0006310

GO:0006974

GO:0007131

GO:0008092

GO:0008094

GO:0016787

GO:0016887

GO:0022414

GO:0032200

GO:0033063

GO:0036297

GO:0042148

GO:0043015

GO:0043226

GO:0050896

GO:0051276

GO:0051726

GO:0140013

GO:0140097

GO:0140299

GO:0140657

GO:0140664

HMNXSV003048312

ILMN_1743356

ILMN_2273921

ILMN_2370907

ILMN_2370910

PH_hs_0007073

TC17001365.hg

TC17002587.hg

TC17002897.hg

g3327885_3p_a_at

g3327885_3p_s_at

Participates

as a candidate of

BRCA1, ATR, FANCD2, FANCI, ATM, MDC1, CHEK1, RAD51D [nucleoplasm] (Homo sapiens)

as an input of

BCDX2 complex formation (Homo sapiens)

as a component of

BCDX2 complex [nucleoplasm] (Homo sapiens)

Inferred To

Ghost homologue of RAD51D [nucleoplasm] (Rattus norvegicus)

RFFL [nucleoplasm] (Canis familiaris)

RAD51D [nucleoplasm] (Bos taurus)

RAD51D [nucleoplasm] (Gallus gallus)

RAD51D [nucleoplasm] (Mus musculus)

RAD51D [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_002869.3, NP_598332.1, NP_001136043.1

OpenTargets

ENSG00000185379

GeneCards

O75771

HPA

ENSG00000185379-RAD51D

Ensembl

ENST00000345365, ENST00000394589, ENSP00000338790, ENST00000587977, ENSP00000378090, ENST00000335858, ENSP00000465366, ENSP00000466399, ENSP00000466587, ENSP00000465584, ENST00000590016, ENSP00000338408, ENSG00000185379, ENST00000588594, ENST00000586044

PRO

O75771

Pharos - Targets

O75771

Orphanet

21074

PDB

8OUZ, 8OUY, 2KZ3, 8GBJ, 8FAZ

Interactors (51)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43543 XRCC2	1	XRCC2 [nucleoplasm] (R-HSA-5685302)	0.979	41
UniProt:Q9UKT9 IKZF3			0.849	11
UniProt:Q9Y2J4 AMOTL2	1	AMOTL2 [cytosol] (R-HSA-2028606)	0.83	8
UniProt:O43502 RAD51C	1	RAD51C [nucleoplasm] (R-HSA-217039)	0.818	8
UniProt:O15315 RAD51B	1	RAD51B [nucleoplasm] (R-HSA-983271)	0.81	8
UniProt:Q9BRK4 LZTS2			0.805	9
UniProt:P19012 KRT15	1	KRT15 [cytosol] (R-HSA-6809589)	0.781	7
UniProt:Q13422 IKZF1			0.742	5
UniProt:Q8IYA8 IHO1			0.718	6
UniProt:Q6P1W5 CA094			0.718	6
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.718	6
UniProt:Q9BVG8 KIFC3			0.666	4
UniProt:P54132 BLM	2	4SUMO2,3-BLM [nucleoplasm] (R-HSA-4568883) BLM [nucleoplasm] (R-HSA-174881)	0.639	4
UniProt:Q9H079 KTBL1			0.556	3
UniProt:P57678 GEMIN4	2	GEMIN4 [nucleoplasm] (R-HSA-191841) GEMIN4 [cytosol] (R-HSA-191836)	0.556	3
UniProt:Q8WUT1 Q8WUT1			0.556	3
UniProt:Q9UPT6 JIP3			0.556	3
UniProt:P15884-3 TCF4			0.556	3
UniProt:Q8ND90 PNMA1			0.556	3
UniProt:Q9UK58 CCNL1			0.556	3
UniProt:Q8NI38 IKBD			0.556	3
UniProt:O60504 SORBS3	1	SORBS3 [cytosol] (R-HSA-445805)	0.556	3
UniProt:Q6P2R3 Q6P2R3			0.556	3
UniProt:Q9Y2B5 VP9D1			0.556	3
IntAct:EBI-16439879 CCSB ORF ID			0.556	3
UniProt:F5H3M2 F5H3M2			0.556	3
UniProt:Q08117-2 TLE5			0.556	3
UniProt:Q5RL73 RBM48			0.556	3
UniProt:Q6P1L6 ZNF343	1	ZNF343 [nucleoplasm] (R-HSA-1247536)	0.556	3
UniProt:Q9NQX0 PRDM6			0.556	3
UniProt:Q9H0A9-2 SPATC1L			0.556	3
UniProt:O75031 HSF2B			0.556	3
UniProt:O75558 STX11			0.556	3
UniProt:Q53FD0-2 ZC2HC1C			0.556	3
UniProt:Q8IYX8-2 CEP57L1			0.556	3
UniProt:Q8N5R6 CCD33			0.556	3
UniProt:Q14142 TRIM14	1	TRIM14 [cytosol] (R-HSA-5624345)	0.556	3
UniProt:Q9Y2J4-4 AMOTL2			0.556	3
UniProt:Q04864-2 REL			0.556	3
UniProt:Q5W5X9-3 TTC23			0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:Q96N21 AP4AT			0.556	3
UniProt:Q5JST6 EFHC2			0.556	3
UniProt:Q9BVG8-5 KIFC3			0.556	3
UniProt:P48059-3 LIMS1			0.556	3
UniProt:B2RXF5 ZBT42			0.556	3
UniProt:Q13422-7 IKZF1			0.556	3
UniProt:Q6NX45 ZNF774	1	ZNF774 [nucleoplasm] (R-HSA-3110232)	0.556	3
UniProt:Q9GZV8 PRDM14	1	PRDM14 [nucleoplasm] (R-HSA-1112608)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:Q6NVH7 SWAP1			0.524	2