Reactome | RAD51C [nucleoplasm]

RAD51C [nucleoplasm]

Stable Identifier

R-HSA-217039

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

DNA repair protein RAD51 homolog 3, (R51H3) (RAD51-like protein 2)

Locations in the PathwayBrowser for interactor UniProt:Q6NVH7 SWAP1

Expand all

External Reference Information

External Reference

UniProt:O43502 RAD51C

Gene Names

RAD51C, RAD51L2

Chain

chain:1-376

Reference Genes

BioGPS Gene:5889 RAD51C

COSMIC (genes):RAD51C RAD51C

CTD Gene:5889 RAD51C

dbSNP Gene:5889 RAD51C

ENSEMBL:ENSG00000108384 RAD51C

ENSEMBL_homo_sapiens_GENE:ENSG00000108384.16 RAD51C

HGNC:9820 RAD51C

KEGG Gene (Homo sapiens):5889 RAD51C

Monarch:5889 RAD51C

NCBI Gene:5889 RAD51C

OMIM:602774 RAD51C

UCSC:O43502 RAD51C

Reference Transcript

Other Identifiers

11724062_a_at

11732520_a_at

11750293_a_at

16836457

206066_PM_s_at

206066_s_at

209849_PM_s_at

209849_s_at

3728777

3728778

3728779

3728786

3728787

3728788

3728789

3728793

3728798

3728802

3728805

3728810

3728813

3728814

3728815

3728817

41479_s_at

41480_at

43342_i_at

43343_r_at

5889

8008754

A_14_P128689

A_23_P207014

A_32_P24359

GO:0000166

GO:0000278

GO:0000400

GO:0000707

GO:0000722

GO:0000724

GO:0003677

GO:0003824

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005657

GO:0005694

GO:0005737

GO:0005739

GO:0005829

GO:0006259

GO:0006281

GO:0006310

GO:0006974

GO:0007059

GO:0007062

GO:0007066

GO:0007131

GO:0007141

GO:0007283

GO:0008821

GO:0010971

GO:0016787

GO:0022414

GO:0030054

GO:0032200

GO:0033063

GO:0033065

GO:0043226

GO:0043231

GO:0048471

GO:0048476

GO:0065003

GO:0140013

GO:0140097

GO:0140299

GO:0140657

GO:0140664

HMNXSV003040725

ILMN_1667644

ILMN_1695386

ILMN_1760635

PH_hs_0019562

g2909800_3p_a_at

g4506390_3p_a_at

Participates

as a component of

as an input of

This entity regulates

Positively

Formation of meiotic single-stranded DNA invasion complex (Homo sapiens)

Inferred To

rad51c [nucleoplasm] (Danio rerio)

rad51c [nucleoplasm] (Xenopus tropicalis)

RAD51C [nucleoplasm] (Bos taurus)

RAD51C [nucleoplasm] (Canis familiaris)

RAD51C [nucleoplasm] (Dictyostelium discoideum)

RAD51C [nucleoplasm] (Gallus gallus)

RAD51C [nucleoplasm] (Mus musculus)

RAD51C [nucleoplasm] (Plasmodium falciparum)

RAD51C [nucleoplasm] (Saccharomyces cerevisiae)

RAD51C [nucleoplasm] (Schizosaccharomyces pombe)

RAD51C [nucleoplasm] (Sus scrofa)

Rad51c [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_002867.1, NP_478123.1

OpenTargets

ENSG00000108384

HPA

ENSG00000108384-RAD51C

GeneCards

O43502

Ensembl

ENSG00000108384, ENST00000337432, ENSP00000336701, ENSP00000391450, ENST00000421782

PRO

O43502

Pharos - Targets

O43502

Orphanet

19136

PDB

8OUY, 8GBJ, 8OUZ, 8FAZ

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43542 XRCC3	1	XRCC3 [nucleoplasm] (R-HSA-5685303)	0.94	12
UniProt:O15315 RAD51B	1	RAD51B [nucleoplasm] (R-HSA-983271)	0.94	16
UniProt:O75771 RAD51D	1	RAD51D [nucleoplasm] (R-HSA-216920)	0.818	8
UniProt:O43543 XRCC2	1	XRCC2 [nucleoplasm] (R-HSA-5685302)	0.744	4
UniProt:Q06609 RAD51	2	RAD51 [nucleoplasm] (R-HSA-62637) p-T309-RAD51 [nucleoplasm] (R-HSA-5685231)	0.662	6
UniProt:Q86YC2 PALB2	20	PALB2 Y28C [nucleoplasm] (R-HSA-9724169) PALB2 L35P [nucleoplasm] (R-HSA-9724168) PALB2 L24S [nucleoplasm] (R-HSA-9724172) PALB2 L21A [nucleoplasm] (R-HSA-9704339) PALB2 R37H [nucleoplasm] (R-HSA-9724178) PALB2 L21F [nucleoplasm] (R-HSA-9704347) PALB2 E12* [nucleoplasm] (R-HSA-9704349) PALB2 R37C [nucleoplasm] (R-HSA-9724188) PALB2 L35F [nucleoplasm] (R-HSA-9704338) PALB2 L947F [nucleoplasm] (R-HSA-9724554) PALB2 G1043D [nucleoplasm] (R-HSA-9724584) PALB2 T1030I [nucleoplasm] (R-HSA-9704424) PALB2 T841Qfs10 [nucleoplasm] (R-HSA-9704749) PALB2 L1119P [nucleoplasm] (R-HSA-9724589) PALB2 L947S [nucleoplasm] (R-HSA-9724557) PALB2 L1143P [nucleoplasm] (R-HSA-9704428) PALB2 L1070P [nucleoplasm] (R-HSA-9724556) PALB2 C77Vfs100 [nucleoplasm] (R-HSA-9704738) PALB2 L939W [nucleoplasm] (R-HSA-9704417) PALB2 L961P [nucleoplasm] (R-HSA-9724583)	0.612	10
UniProt:P51587 BRCA2	20	BRCA2 D2983Ffs34 [cytosol] (R-HSA-9709538) BRCA2 K2555 [cytosol] (R-HSA-9711337) BRCA2 N2553Tfs95 [cytosol] (R-HSA-9712872) BRCA2 T2685Hfs9 [cytosol] (R-HSA-9712879) BRCA2 K2674Rfs2 [cytosol] (R-HSA-9712610) BRCA2 S3231 [cytosol] (R-HSA-9711458) BRCA2 I2675Dfs6 [cytosol] (R-HSA-9712869) BRCA2 R2625 [cytosol] (R-HSA-9711482) BRCA2 E3071* [cytosol] (R-HSA-9711354) BRCA2 V2716Wfs17 [cytosol] (R-HSA-9712761) BRCA2 W2586 [cytosol] (R-HSA-9711487) BRCA2 P2767Lfs10 [cytosol] (R-HSA-9712509) BRCA2 K3032 [cytosol] (R-HSA-9711485) BRCA2 S2835* [cytosol] (R-HSA-9711345) BRCA2 Y3006* [cytosol] (R-HSA-9711222) BRCA2 L2926* [cytosol] (R-HSA-9711348) BRCA2 R3128* [cytosol] (R-HSA-9711177) BRCA2 E2599* [cytosol] (R-HSA-9711304) BRCA2 E2571* [cytosol] (R-HSA-9711560) BRCA2 Y2977* [cytosol] (R-HSA-9711182)	0.532	5
UniProt:Q15768 EFNB3	2	p-Y318,Y323,Y337-EFNB3 [plasma membrane] (R-HSA-3928388) EFNB3 [plasma membrane] (R-HSA-2682319)	0.527	2
UniProt:P43378 PTPN9	1	PTPN9 [nucleoplasm] (R-HSA-9008907)	0.527	2
UniProt:Q9HBV2 SACA1			0.527	2
UniProt:Q8TBP5 F174A			0.527	2
UniProt:Q9UK85 DKKL1			0.527	3
UniProt:Q6JEL2 KLH10			0.527	2
UniProt:Q6NVH7 SWAP1			0.524	2
UniProt:Q8TDG4 HELQ			0.499	6

Cite Us!