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NEDD4L [nucleoplasm]
Stable Identifier
R-HSA-2176420
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
E3 ubiquitin-protein ligase NEDD4-like, NED4L_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Homo sapiens)
NEDD4L binds phosphorylated linker region of SMAD2/3 (Homo sapiens)
NEDD4L [nucleoplasm] (Homo sapiens)
p-T-2S-SMAD2,3:SMAD4:NEDDL4 [nucleoplasm] (Homo sapiens)
NEDD4L [nucleoplasm] (Homo sapiens)
NEDD4L ubiquitinates SMAD2/3 (Homo sapiens)
NEDD4L [nucleoplasm] (Homo sapiens)
p-T-2S-SMAD2,3:SMAD4:NEDDL4 [nucleoplasm] (Homo sapiens)
NEDD4L [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
TGF-beta receptor signaling activates SMADs (Homo sapiens)
Downregulation of TGF-beta receptor signaling (Homo sapiens)
NEDD4L ubiquitin ligase binds SMAD7 (Homo sapiens)
NEDD4L [nucleoplasm] (Homo sapiens)
SMAD7:NEDD4L [nucleoplasm] (Homo sapiens)
NEDD4L [nucleoplasm] (Homo sapiens)
SMAD7:NEDD4L complex translocates to the cytosol (Homo sapiens)
SMAD7:NEDD4L [nucleoplasm] (Homo sapiens)
NEDD4L [nucleoplasm] (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Homo sapiens)
NEDD4L binds phosphorylated linker region of SMAD2/3 (Homo sapiens)
NEDD4L [nucleoplasm] (Homo sapiens)
p-T-2S-SMAD2,3:SMAD4:NEDDL4 [nucleoplasm] (Homo sapiens)
NEDD4L [nucleoplasm] (Homo sapiens)
NEDD4L ubiquitinates SMAD2/3 (Homo sapiens)
NEDD4L [nucleoplasm] (Homo sapiens)
p-T-2S-SMAD2,3:SMAD4:NEDDL4 [nucleoplasm] (Homo sapiens)
NEDD4L [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96PU5 NEDD4L
Gene Names
NEDD4L, KIAA0439, NEDL3
Chain
initiator methionine:, chain:2-975
Reference Genes
COSMIC (genes):NEDD4L NEDD4L
dbSNP Gene:23327 NEDD4L
ENSEMBL:ENSG00000049759 NEDD4L
Participates
as a component of
Smad7:NEDD4L [nucleoplasm] (Homo sapiens)
SMAD7:NEDD4L [nucleoplasm] (Homo sapiens)
p-T-2S-SMAD2,3:SMAD4:NEDDL4 [nucleoplasm] (Homo sapiens)
as an input of
NEDD4L binds Smad7 (Homo sapiens)
NEDD4L ubiquitin ligase binds SMAD7 (Homo sapiens)
NEDD4L binds phosphorylated linker region of SMAD2/3 (Homo sapiens)
as an output of
NEDD4L ubiquitinates SMAD2/3 (Homo sapiens)
Other forms of this molecule
NEDD4L [cytosol]
Inferred To
Nedd4 [nucleoplasm]
(Drosophila melanogaster)
Nedd4l [nucleoplasm]
(Mus musculus)
Nedd4l [nucleoplasm]
(Rattus norvegicus)
NEDD4L [nucleoplasm]
(Bos taurus)
NEDD4L [nucleoplasm]
(Caenorhabditis elegans)
NEDD4L [nucleoplasm]
(Canis familiaris)
NEDD4L [nucleoplasm]
(Gallus gallus)
NEDD4L [nucleoplasm]
(Sus scrofa)
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.758
5
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.745
5
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.727
6
UniProt:Q96B67 ARRD3
0.702
4
UniProt:Q9BZD6 TMG4
0.656
3
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.615
8
UniProt:Q15038 DAZP2
0.556
3
UniProt:Q13571 LAPM5
0.547
2
UniProt:Q15884 EREP1
0.547
4
UniProt:Q4VCS5 AMOT
0.527
2
UniProt:Q8N5I2 ARRD1
0.527
4
UniProt:Q8NCT1 ARRD4
0.527
2
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.483
2
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.471
2
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