Reactome | NEDD4L [nucleoplasm]

NEDD4L [nucleoplasm]

Stable Identifier

R-HSA-2176420

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

E3 ubiquitin-protein ligase NEDD4-like, NED4L_HUMAN

Icon

Locations in the PathwayBrowser for interactor UniProt:Q13571 LAPM5

Expand all

External Reference Information

External Reference

UniProt:Q96PU5 NEDD4L

Gene Names

NEDD4L, KIAA0439, NEDL3

Chain

initiator methionine:, chain:2-975

Reference Genes

BioGPS Gene:23327 NEDD4L

COSMIC (genes):NEDD4L NEDD4L

CTD Gene:23327 NEDD4L

dbSNP Gene:23327 NEDD4L

ENSEMBL:ENSG00000049759 NEDD4L

HGNC:7728 NEDD4L

KEGG:hsa:23327 NEDD4L

Monarch:23327 NEDD4L

NCBI Gene:23327 NEDD4L

OMIM:606384 NEDD4L

UCSC:Q96PU5 NEDD4L

Reference Transcript

Participates

as a component of

as an input of

as an output of

NEDD4L ubiquitinates SMAD2/3 (Homo sapiens)

Other forms of this molecule

NEDD4L [cytosol]

Inferred To

Nedd4 [nucleoplasm] (Drosophila melanogaster)

Nedd4l [nucleoplasm] (Mus musculus)

Nedd4l [nucleoplasm] (Rattus norvegicus)

NEDD4L [nucleoplasm] (Bos taurus)

NEDD4L [nucleoplasm] (Caenorhabditis elegans)

NEDD4L [nucleoplasm] (Canis familiaris)

NEDD4L [nucleoplasm] (Gallus gallus)

NEDD4L [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_001138436.1, NP_001138437.1, XP_047293360.1, XP_047293361.1, NP_001138439.1, NP_001138438.1, XP_024306903.1, XP_024306904.1, XP_016881168.1, NP_056092.2, XP_054174386.1, XP_054174387.1, XP_054174365.1, NP_001230889.1, XP_047293359.1, XP_047293373.1, XP_047293358.1, XP_047293374.1, XP_054174372.1, XP_054174367.1, XP_054174388.1, XP_047293375.1, XP_054174366.1, XP_054174389.1, XP_054174371.1, XP_024306897.1, XP_054174391.1, XP_054174392.1, NP_001138440.1, NP_001138443.1, XP_024306899.1, NP_001138441.1, NP_001138442.1, XP_054174368.1

OpenTargets

ENSG00000049759

ENSEMBL

ENSP00000256830, ENSP00000372301, ENSG00000049759, ENST00000435432, ENST00000675801, ENSP00000389406, ENST00000674517, ENSP00000501665, ENST00000431212, ENST00000356462, ENST00000357895, ENST00000675865, ENSP00000350569, ENST00000675502, ENST00000256830, ENSP00000393395, ENSP00000383199, ENST00000400345, ENSP00000502688, ENSP00000411947, ENSP00000348847, ENSP00000502325, ENST00000382850, ENST00000456173, ENSP00000502003, ENST00000586263, ENSP00000468546, ENSP00000502428, ENST00000676226, ENST00000456986, ENSP00000405440

GeneCards

NEDD4L

HPA

ENSG00000049759-NEDD4L

PRO

Q96PU5

Pharos - Targets

Q96PU5

GlyGen

Q96PU5

Orphanet

NEDD4L

HMDB Protein

HMDBP02282

PDB

7NMZ, 3JW0, 7LP3, 7LP5, 2LB2, 7LP1, 6ZC9, 7LP4, 5HPK, 3JVZ, 7LP2, 6ZBT, 2NSQ, 2ONI, 2LTY, 2MPT, 2LAJ

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96B67 ARRD3			0.768	5
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.758	5
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.745	5
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.727	6
UniProt:Q15884 EREP1			0.659	5
UniProt:Q9BZD6 TMG4			0.656	3
UniProt:Q8N5I2 ARRD1			0.643	5
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	8
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.569	3
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.569	3
UniProt:Q15038 DAZP2			0.556	3
UniProt:Q13571 LAPM5			0.547	2
UniProt:Q9UH99 SUN2	1	SUN2 [nuclear envelope] (R-HSA-912382)	0.527	2
UniProt:Q9H0E2 TOLLIP	4	TOLLIP [cytosol] (R-HSA-446885) TOLLIP [azurophil granule lumen] (R-HSA-6799709) TOLLIP [extracellular region] (R-HSA-6800448) TOLLIP [specific granule lumen] (R-HSA-6799719)	0.527	2
UniProt:Q92796 DLG3	2	DLG3 [plasma membrane] (R-HSA-443609) DLG3 [cytosol] (R-HSA-6794232)	0.527	2
UniProt:Q8NCT1 ARRD4			0.527	2
UniProt:Q8WVE6 TM171			0.527	3
UniProt:P81408 EREP3			0.527	4
UniProt:O15165 LRAD4			0.527	4
UniProt:Q4VCS5 AMOT			0.527	2
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.483	2
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.471	2

Cite Us!