NEDD4L ubiquitinates SMAD2/3

Stable Identifier
R-HSA-2176502
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
NEDD4L ubiquitinates SMAD2/3
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
NEDD4L ubiquitinates nuclear SMAD2 and SMAD3 phosphorylated at the linker region by CDK8 or CDK9, targeting SMAD2 and SMAD3 for degradation.
Literature References
PubMed ID Title Journal Year
19917253 Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling

Massague, J, Chen, PY, Macias, MJ, Tempst, P, Goerner, N, Gao, S, Sapkota, G, Alarcon, C, Erdjument-Bromage, H, Rahman, S

Mol Cell 2009
Participants
Input
Output
Participates
as an event of
Orthologous Events
NEDD4L ubiquitinates SMAD2/3 (Bos taurus)
NEDD4L ubiquitinates SMAD2/3 (Caenorhabditis elegans)
NEDD4L ubiquitinates SMAD2/3 (Canis familiaris)
NEDD4L ubiquitinates SMAD2/3 (Drosophila melanogaster)
NEDD4L ubiquitinates SMAD2/3 (Gallus gallus)
NEDD4L ubiquitinates SMAD2/3 (Mus musculus)
NEDD4L ubiquitinates SMAD2/3 (Rattus norvegicus)
NEDD4L ubiquitinates SMAD2/3 (Sus scrofa)
Authored
Orlic-Milacic, M  (2012-04-05)
Reviewed
Huang, T  (2012-05-14)
Contreras, O  (2022-05-02)
Created
Orlic-Milacic, M  (2012-04-03)
Cite Us!