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TGIF1 [nucleoplasm]
Stable Identifier
R-HSA-2186594
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
TGIF, Homeobox protein TGIF1
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Homo sapiens)
TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Homo sapiens)
TGIF [nucleoplasm] (Homo sapiens)
TGIF1 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4:TGIF:HDAC1 [nucleoplasm] (Homo sapiens)
TGIF [nucleoplasm] (Homo sapiens)
TGIF1 [nucleoplasm] (Homo sapiens)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
WWTR1:SMAD stimulates transcription of SERPINE1 while TGIF:SMAD and SMAD7 inhibit it (Homo sapiens)
p-2S-SMAD2/3:SMAD4:TGIF:HDAC1 [nucleoplasm] (Homo sapiens)
TGIF [nucleoplasm] (Homo sapiens)
TGIF1 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Homo sapiens)
TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Homo sapiens)
TGIF [nucleoplasm] (Homo sapiens)
TGIF1 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4:TGIF:HDAC1 [nucleoplasm] (Homo sapiens)
TGIF [nucleoplasm] (Homo sapiens)
TGIF1 [nucleoplasm] (Homo sapiens)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
WWTR1:SMAD stimulates transcription of SERPINE1 while TGIF:SMAD and SMAD7 inhibit it (Homo sapiens)
p-2S-SMAD2/3:SMAD4:TGIF:HDAC1 [nucleoplasm] (Homo sapiens)
TGIF [nucleoplasm] (Homo sapiens)
TGIF1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15583 TGIF1
Gene Names
TGIF1, TGIF
Chain
chain:1-401
Reference Genes
BioGPS Gene:7050 TGIF1
COSMIC (genes):TGIF1 TGIF1
CTD Gene:7050 TGIF1
dbSNP Gene:7050 TGIF1
ENSEMBL:ENSG00000177426 TGIF1
ENSEMBL:ENSG00000177426.22 TGIF1
HGNC:11776 TGIF1
KEGG Gene (Homo sapiens):7050 TGIF1
Monarch:7050 TGIF1
NCBI Gene:7050 TGIF1
OMIM:602630 TGIF1
UCSC:Q15583 TGIF1
Reference Transcript
RefSeq:NM_003244.3 TGIF1
RefSeq:NM_170695.3 TGIF1
RefSeq:NM_173209.2 TGIF1
RefSeq:NM_001278686.1 TGIF1
RefSeq:NM_173208.2 TGIF1
RefSeq:XM_017025958.1 TGIF1
RefSeq:XM_017025959.1 TGIF1
RefSeq:XM_011525735.2 TGIF1
RefSeq:NM_174886.2 TGIF1
RefSeq:NM_001278684.1 TGIF1
RefSeq:NM_001278682.1 TGIF1
RefSeq:NM_173207.2 TGIF1
RefSeq:NM_173211.1 TGIF1
RefSeq:NM_173210.2 TGIF1
Other Identifiers
11740681_a_at
11740938_a_at
203313_PM_s_at
203313_s_at
244858_PM_at
244858_at
3776505
3776506
3776507
3776508
3776510
3776511
3776512
3776513
3776515
3776516
3776517
3776518
3776519
3776520
3776521
3776522
3776523
3776524
3776525
3776527
3776528
3776529
3776530
3776531
3776532
3776533
3776534
3776535
3776539
3776540
3776541
3776542
3776543
3776544
3776545
3776546
3776547
3776548
3776549
3776550
3776558
3865929
3865933
38805_at
7050
72858_at
8019939
8180316
8180317
8180318
8180319
A_14_P105321
A_14_P201918
A_21_P0000192
A_33_P3311717
GE558171
GE60124
GE705168
GE789470
GO:0000122
GO:0000785
GO:0000978
GO:0000981
GO:0001227
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0006351
GO:0006355
GO:0009410
GO:0010629
GO:0043226
GO:0070410
GO:0071363
GO:0140110
GO:1990837
HMNXSV003026422
Hs.233297.0.A1_3p_at
ILMN_1656761
ILMN_1702211
ILMN_1754102
ILMN_2245292
ILMN_2247842
ILMN_2318638
ILMN_2318643
PH_hs_0027910
X89750_at
g4507472_3p_a_at
Participates
as a member of
TGIF [nucleoplasm] (Homo sapiens)
Inferred To
TGIF1 [nucleoplasm]
(Bos taurus)
TGIF1 [nucleoplasm]
(Canis familiaris)
TGIF1 [nucleoplasm]
(Sus scrofa)
tgif1 [nucleoplasm]
(Xenopus tropicalis)
TGIF [nucleoplasm]
(Danio rerio)
vis [nucleoplasm]
(Drosophila melanogaster)
achi [nucleoplasm]
(Drosophila melanogaster)
Homologues of TGIF1 [nucleoplasm]
(Drosophila melanogaster)
Tgif1 [nucleoplasm]
(Mus musculus)
Tgif1 [nucleoplasm]
(Rattus norvegicus)
Cross References
RefSeq
NP_001265613.1
,
XP_016881447.1
,
NP_775302.1
,
NP_001265611.1
,
XP_011524037.1
,
NP_775299.1
,
NP_775303.1
,
NP_775300.1
,
NP_733796.2
,
NP_003235.1
,
NP_775301.1
,
NP_001265615.1
,
XP_016881448.1
,
NP_777480.1
OpenTargets
ENSG00000177426
HPA
ENSG00000177426-TGIF1
GeneCards
Q15583
Ensembl
ENSP00000383031
,
ENST00000400167
,
ENST00000551541
,
ENSP00000384970
,
ENSP00000384133
,
ENST00000548489
,
ENSP00000339631
,
ENSP00000483499
,
ENST00000618001
,
ENST00000472042
,
ENSP00000343969
,
ENST00000343820
,
ENSP00000385206
,
ENST00000345133
,
ENST00000401449
,
ENSP00000450025
,
ENST00000405385
,
ENSG00000177426
,
ENSP00000327959
,
ENSP00000449501
,
ENST00000330513
,
ENST00000407501
,
ENSP00000447747
PRO
Q15583
Pharos - Targets
Q15583
Orphanet
15612
PDB
6FQQ
,
2LK2
,
6FQP
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y2T1 AXIN2
4
AXIN2 [cytosol]
(R-HSA-3640821)
RibC-AXIN2 [cytosol]
(R-HSA-3640842)
Ub-RibC-AXIN2 [cytosol]
(R-HSA-3640859)
ub-AXIN2 [cytosol]
(R-HSA-4641131)
0.567
5
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:P53350 PLK1
4
PLK1 [nucleoplasm]
(R-HSA-156720)
p-T210-PLK1 [cytosol]
(R-HSA-3000318)
p-T210-PLK1 [nucleoplasm]
(R-HSA-3002800)
PLK1 [cytosol]
(R-HSA-164603)
0.556
3
UniProt:O14494 PLPP1
1
PPAP2A [plasma membrane]
(R-HSA-76106)
0.556
3
UniProt:P84022 SMAD3
20
Ub-SMAD3 [cytosol]
(R-HSA-6782830)
p-S423,S425-SMAD3 D258N [cytosol]
(R-HSA-3315470)
p-S423,S425-SMAD3 R268C [cytosol]
(R-HSA-3315075)
p-S423,S425-SMAD3 R268H [cytosol]
(R-HSA-3315080)
SMAD3 Q316* [cytosol]
(R-HSA-9668765)
SMAD3 Y384* [cytosol]
(R-HSA-9668782)
SMAD3 W326* [cytosol]
(R-HSA-9668766)
SMAD3 E246* [cytosol]
(R-HSA-9668776)
SMAD3 Q358* [cytosol]
(R-HSA-9668772)
SMAD3 Q322* [cytosol]
(R-HSA-9668773)
SMAD3 S425F [cytosol]
(R-HSA-8944158)
SMAD3 E383* [cytosol]
(R-HSA-9668775)
SMAD3 R368* [cytosol]
(R-HSA-9668768)
SMAD3 Y298* [cytosol]
(R-HSA-9668769)
SMAD3 S425C [cytosol]
(R-HSA-3308499)
p-S208-SMAD3 [cytosol]
(R-HSA-9731114)
SMAD3 [nucleoplasm]
(R-HSA-206150)
2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2187326)
Ub,p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-9773841)
p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2176471)
0.556
3
UniProt:P29590 PML
5
polySUMO3-K65,K160,K490-PML [nucleoplasm]
(R-HSA-3000386)
polySUMO2-K65,K160,K490-PML [nucleoplasm]
(R-HSA-3000423)
monoSUMO1-K65,160,490-PML [nucleoplasm]
(R-HSA-3000440)
PML [nucleoplasm]
(R-HSA-1031706)
PML [cytosol]
(R-HSA-5624327)
0.556
3
UniProt:Q13363 CTBP1
3
monoSUMO1-K428-CTBP1 [nucleoplasm]
(R-HSA-3108200)
polySUMO2,3-K428-CTBP1 [nucleoplasm]
(R-HSA-3108226)
CTBP1 [nucleoplasm]
(R-HSA-212372)
0.508
2
UniProt:O15169 AXIN1
11
AXIN1 L396M [cytosol]
(R-HSA-5251503)
AXIN1 Y346* [cytosol]
(R-HSA-4839753)
AXIN1 E406* [cytosol]
(R-HSA-5251500)
AXIN1 W247* [cytosol]
(R-HSA-5251512)
AXIN1 P354L [cytosol]
(R-HSA-5251511)
AXIN1 P255S [cytosol]
(R-HSA-5251505)
ub-AXIN1 [cytosol]
(R-HSA-4641133)
Ub-RibC-AXIN1 [cytosol]
(R-HSA-3640864)
AXIN1 [cytosol]
(R-HSA-195249)
p-T481,S486,S493-AXIN1 [cytosol]
(R-HSA-206040)
RibC-AXIN1 [cytosol]
(R-HSA-3640841)
0.499
4
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