Reactome | Ubiquitination of SKI/SKIL by RNF111/SMURF2

Ubiquitination of SKI/SKIL by RNF111/SMURF2

Stable Identifier

R-HSA-2186747

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Ubiquitination of SKI/SKIL by RNF111/SMURF2

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E3 ubiqutin ligases RNF111 (Arkadia) (Levy et al. 2007, Nagano et al. 2007) and SMURF2 (Bonni et al. 2001) ubiquitinate SKI/SKIL transcriptional repressors bound to activated SMAD2/3. The role of RNF111 was inferred from experiments that used recombinant mouse RNF111 and endogenous human SMADs and SKI/SKIL. The role of SMURF2 was inferred from experiments involving human proteins only.

Literature References

PubMed ID	Title	Journal	Year
17591695	Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation Episkopou, V, Levy, L, Harkin, S, Hill, CS, Das, D, Howell, M	Mol Cell Biol	2007
17510063	Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-beta signaling Episkopou, V, Miyazono, K, Yuki, K, Nagano, Y, Lee, KL, Imamura, T, Isogaya, K, Saitoh, M, Koinuma, D, Mavrakis, KJ, Fujii, T, Sase, H, Miyazawa, K	J Biol Chem	2007
11389444	TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation Wrana, JL, Luo, K, Bonni, S, Wang, HR, Stroschein, SL, Causing, CG, Kavsak, P	Nat Cell Biol	2001