E3 ubiqutin ligases RNF111 (Arkadia) (Levy et al. 2007, Nagano et al. 2007) and SMURF2 (Bonni et al. 2001) ubiquitinate SKI/SKIL transcriptional repressors bound to activated SMAD2/3. The role of RNF111 was inferred from experiments that used recombinant mouse RNF111 and endogenous human SMADs and SKI/SKIL. The role of SMURF2 was inferred from experiments involving human proteins only.
Episkopou, V, Levy, L, Harkin, S, Hill, CS, Das, D, Howell, M
Episkopou, V, Miyazono, K, Yuki, K, Nagano, Y, Lee, KL, Imamura, T, Isogaya, K, Saitoh, M, Koinuma, D, Mavrakis, KJ, Fujii, T, Sase, H, Miyazawa, K
Wrana, JL, Luo, K, Bonni, S, Wang, HR, Stroschein, SL, Causing, CG, Kavsak, P
ubiquitin-protein transferase activity of p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR:RNF111/SMURF2 [nucleoplasm]
© 2023 Reactome
