RNF111 ubiquitinates SMAD7

Stable Identifier
R-HSA-2186785
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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RNF111 ubiquitinates SMAD7
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RNF111 (Arkadia) polyubiquitinates SMAD7 (Koinuma et al. 2003). This was inferred from studies using recombinant mouse Smad7 and recombinant mouse Rnf111 expressed in human embryonic kidney cell line HEK293.

Literature References
PubMed ID Title Journal Year
14657019 Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7

Miyazono, K, Goto, K, Shinozaki, M, Imamura, T, Nukiwa, T, Komuro, A, Ebina, M, Miyazawa, K, Saitoh, M, Hanyu, A, Koinuma, D

EMBO J 2003
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Catalyst Activity

ubiquitin-protein transferase activity of SMAD7:RNF111 [nucleoplasm]

Physical Entity
SMAD7:RNF111 [nucleoplasm] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Inferred From
Rnf111 ubiquitinates Smad7 (Homo sapiens)
Authored
Orlic-Milacic, M  (2012-04-05)
Reviewed
Huang, T  (2012-05-14)
Contreras, O  (2022-05-02)
Created
Orlic-Milacic, M  (2012-04-05)
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