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Cytosolic CMs translocate to extracellular region
Stable Identifier
R-HSA-2187332
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
,
extracellular region
Synonyms
Chylomicron secretion into the lymphatic system
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of fat-soluble vitamins (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
Cytosolic CMs translocate to extracellular region (Homo sapiens)
Sensory Perception (Homo sapiens)
Visual phototransduction (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
Cytosolic CMs translocate to extracellular region (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Nascent chylomicrons (CM) containing all-trans-retinyl esters (atREs) are secreted from intestinal cells and transported to the liver via the lymphatic system (Nayak et al. 2001, During & Harrison 2007).
Literature References
PubMed ID
Title
Journal
Year
17644776
Mechanisms of provitamin A (carotenoid) and vitamin A (retinol) transport into and out of intestinal Caco-2 cells
During, A
,
Harrison, EH
J Lipid Res
2007
11181758
Retinyl ester secretion by intestinal cells: a specific and regulated process dependent on assembly and secretion of chylomicrons
Hussain, MM
,
Harrison, EH
,
Nayak, N
J Lipid Res
2001
Participants
Input
nascent CM:atREs [cytosol]
(Homo sapiens)
Output
nascent CM:atREs [extracellular region]
(Homo sapiens)
Participates
as an event of
Retinoid metabolism and transport (Homo sapiens)
Orthologous Events
Cytosolic CMs translocate to extracellular region (Bos taurus)
Cytosolic CMs translocate to extracellular region (Canis familiaris)
Cytosolic CMs translocate to extracellular region (Gallus gallus)
Cytosolic CMs translocate to extracellular region (Mus musculus)
Cytosolic CMs translocate to extracellular region (Rattus norvegicus)
Cytosolic CMs translocate to extracellular region (Sus scrofa)
Authored
Jassal, B (2012-04-09)
Reviewed
Blaner, WS (2013-01-31)
Created
Jassal, B (2012-04-09)
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