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WIPF2 [cytosol]
Stable Identifier
R-HSA-2197666
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
WAS/WASL-interacting protein family member 2, WIPF2_HUMAN, WICH, WIRE
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Parasite infection (Homo sapiens)
Leishmania phagocytosis (Homo sapiens)
FCGR3A-mediated phagocytosis (Homo sapiens)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF2 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF2 [cytosol] (Homo sapiens)
Detachment of WASP/WAVE (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF2 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF2 [cytosol] (Homo sapiens)
Src phosphorylate WASP,N-WASP (Homo sapiens)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF2 [cytosol] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF2 [cytosol] (Homo sapiens)
WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF2 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF2 [cytosol] (Homo sapiens)
WIP binds WASP,N-WASP, activating them (Homo sapiens)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF2 [cytosol] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF2 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF2 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF2 [cytosol] (Homo sapiens)
Detachment of WASP/WAVE (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF2 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF2 [cytosol] (Homo sapiens)
Src phosphorylate WASP,N-WASP (Homo sapiens)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF2 [cytosol] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF2 [cytosol] (Homo sapiens)
WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF2 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF2 [cytosol] (Homo sapiens)
WIP binds WASP,N-WASP, activating them (Homo sapiens)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF2 [cytosol] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate WASPs and WAVEs (Homo sapiens)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF2 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF2 [cytosol] (Homo sapiens)
Detachment of WASP/WAVE (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF2 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF2 [cytosol] (Homo sapiens)
Src phosphorylate WASP,N-WASP (Homo sapiens)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF2 [cytosol] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF2 [cytosol] (Homo sapiens)
WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF2 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF2 [cytosol] (Homo sapiens)
WIP binds WASP,N-WASP, activating them (Homo sapiens)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF2 [cytosol] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF2 [cytosol] (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
CDC42 GTPase cycle (Homo sapiens)
CDC42 binds effectors at the plasma membrane (Homo sapiens)
CDC42 effectors [cytosol] (Homo sapiens)
WIP:WASP complex [cytosol] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF2 [cytosol] (Homo sapiens)
CDC42:GTP:CDC42 effectors [plasma membrane] (Homo sapiens)
CDC42 effectors [cytosol] (Homo sapiens)
WIP:WASP complex [cytosol] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF2 [cytosol] (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 binds effectors at the plasma membrane (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
WIP:WASP complex [cytosol] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF2 [cytosol] (Homo sapiens)
RAC1:GTP:RAC1 effectors [plasma membrane] (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
WIP:WASP complex [cytosol] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF2 [cytosol] (Homo sapiens)
RHOJ GTPase cycle (Homo sapiens)
RHOJ binds effectors at the plasma membrane (Homo sapiens)
RHOJ effectors [cytosol] (Homo sapiens)
WIP2:WASP complex [cytosol] (Homo sapiens)
WIPF2 [cytosol] (Homo sapiens)
RHOJ:GTP:RHOJ effectors [plasma membrane] (Homo sapiens)
RHOJ effectors [cytosol] (Homo sapiens)
WIP2:WASP complex [cytosol] (Homo sapiens)
WIPF2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8TF74 WIPF2
Gene Names
WIPF2, WICH, WIRE, PP10631
Chain
chain:1-440
Reference Genes
BioGPS Gene:147179 WIPF2
COSMIC (genes):WIPF2 WIPF2
CTD Gene:147179 WIPF2
dbSNP Gene:147179 WIPF2
ENSEMBL:ENSG00000171475 WIPF2
HGNC:30923 WIPF2
KEGG:hsa:147179 WIPF2
Monarch:147179 WIPF2
NCBI Gene:147179 WIPF2
OMIM:609692 WIPF2
UCSC:Q8TF74 WIPF2
Reference Transcript
RefSeq:NM_133264.4 WIPF2
RefSeq:XM_005257084.2 WIPF2
RefSeq:XM_011524413.1 WIPF2
RefSeq:XM_005257083.2 WIPF2
Other Identifiers
11720975_a_at
11720976_at
11749248_a_at
11756713_a_at
11758840_at
147179
16834045
212049_PM_at
212049_at
212050_PM_at
212050_at
212051_PM_at
212051_at
231251_PM_at
231251_at
3331618
3720856
3720867
3720868
3720870
3720871
3720872
3720873
3720874
3720875
3720879
3720880
3720881
3720882
3720883
3720884
3720885
3720886
3720889
3720893
3720895
3720897
3720898
3720899
3720900
40787_at
48933_at
8007058
83787_at
A_14_P101872
A_23_P136325
A_23_P366455
A_24_P838748
A_33_P3274304
GE518121
GE59552
GE84991
GO:0003779
GO:0005515
GO:0005737
GO:0005829
GO:0005856
GO:0008092
GO:0043226
HMNXSV003011585
Hs.13996.0.S1_3p_at
Hs.13996.0.S2_3p_at
Hs.13996.0.S3_3p_at
Hs.157716.0.A1_3p_at
ILMN_1775171
PH_hs_0025147
TC17000493.hg
U90911_at
Participates
as a component of
WIP2:WASP complex [cytosol] (Homo sapiens)
as a member of
WIP family proteins [cytosol] (Homo sapiens)
Cross References
RefSeq
NP_573571.1
,
XP_005257140.1
,
XP_005257141.1
,
XP_011522715.1
ENSEMBL
ENSP00000462826
,
ENST00000583130
,
ENSP00000320924
,
ENSP00000462350
,
ENST00000323571
,
ENST00000585043
OpenTargets
ENSG00000171475
HPA
ENSG00000171475-WIPF2
PRO
Q8TF74
Pharos - Targets
Q8TF74
GlyGen
Q8TF74
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.85
7
UniProt:O00401 WASL
4
p-Y256-WASL [cytosol]
(R-HSA-2197672)
N-WASP [cytosol]
(R-HSA-201873)
WASL [plasma membrane]
(R-HSA-203010)
WASL [endocytic vesicle membrane]
(R-HSA-535012)
0.847
8
UniProt:O43639 NCK2
1
NCK2 [cytosol]
(R-HSA-204885)
0.527
3
UniProt:P16333 NCK1
2
NCK1 [plasma membrane]
(R-HSA-202992)
NCK1 [cytosol]
(R-HSA-197954)
0.527
3
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