Reactome | p-Y256-WASL [cytosol]

p-Y256-WASL [cytosol]

Stable Identifier

R-HSA-2197672

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-Y256-N-WASP

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Parasite infection (Homo sapiens)
        
        Leishmania phagocytosis (Homo sapiens)
        
        FCGR3A-mediated phagocytosis (Homo sapiens)
        
        (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        p-Y291-WASP/p-Y256-N-WASP [cytosol] (Homo sapiens)
        
        p-Y256-WASL [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        p-Y291-WASP/p-Y256-N-WASP [cytosol] (Homo sapiens)
        
        p-Y256-WASL [cytosol] (Homo sapiens)
        
        Detachment of WASP/WAVE (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        p-Y291-WASP/p-Y256-N-WASP [cytosol] (Homo sapiens)
        
        p-Y256-WASL [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        p-Y291-WASP/p-Y256-N-WASP [cytosol] (Homo sapiens)
        
        p-Y256-WASL [cytosol] (Homo sapiens)
        
        Src phosphorylate WASP,N-WASP (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        p-Y291-WASP/p-Y256-N-WASP [cytosol] (Homo sapiens)
        
        p-Y256-WASL [cytosol] (Homo sapiens)
        
        WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        p-Y291-WASP/p-Y256-N-WASP [cytosol] (Homo sapiens)
        
        p-Y256-WASL [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        p-Y291-WASP/p-Y256-N-WASP [cytosol] (Homo sapiens)
        
        p-Y256-WASL [cytosol] (Homo sapiens)

Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
    - Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        p-Y291-WASP/p-Y256-N-WASP [cytosol] (Homo sapiens)
        
        p-Y256-WASL [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        p-Y291-WASP/p-Y256-N-WASP [cytosol] (Homo sapiens)
        
        p-Y256-WASL [cytosol] (Homo sapiens)
      - Detachment of WASP/WAVE (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        p-Y291-WASP/p-Y256-N-WASP [cytosol] (Homo sapiens)
        
        p-Y256-WASL [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        p-Y291-WASP/p-Y256-N-WASP [cytosol] (Homo sapiens)
        
        p-Y256-WASL [cytosol] (Homo sapiens)
      - Src phosphorylate WASP,N-WASP (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        p-Y291-WASP/p-Y256-N-WASP [cytosol] (Homo sapiens)
        
        p-Y256-WASL [cytosol] (Homo sapiens)
      - WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        p-Y291-WASP/p-Y256-N-WASP [cytosol] (Homo sapiens)
        
        p-Y256-WASL [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        p-Y291-WASP/p-Y256-N-WASP [cytosol] (Homo sapiens)
        
        p-Y256-WASL [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase Effectors (Homo sapiens)
      - RHO GTPases Activate WASPs and WAVEs (Homo sapiens)
        
        (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        p-Y291-WASP/p-Y256-N-WASP [cytosol] (Homo sapiens)
        
        p-Y256-WASL [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        p-Y291-WASP/p-Y256-N-WASP [cytosol] (Homo sapiens)
        
        p-Y256-WASL [cytosol] (Homo sapiens)
        
        Detachment of WASP/WAVE (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        p-Y291-WASP/p-Y256-N-WASP [cytosol] (Homo sapiens)
        
        p-Y256-WASL [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        p-Y291-WASP/p-Y256-N-WASP [cytosol] (Homo sapiens)
        
        p-Y256-WASL [cytosol] (Homo sapiens)
        
        Src phosphorylate WASP,N-WASP (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        p-Y291-WASP/p-Y256-N-WASP [cytosol] (Homo sapiens)
        
        p-Y256-WASL [cytosol] (Homo sapiens)
        
        WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        p-Y291-WASP/p-Y256-N-WASP [cytosol] (Homo sapiens)
        
        p-Y256-WASL [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        p-Y291-WASP/p-Y256-N-WASP [cytosol] (Homo sapiens)
        
        p-Y256-WASL [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O00401 WASL

Gene Names

WASL

Chain

initiator methionine:, chain:2-505

Reference Genes

BioGPS Gene:8976 WASL

COSMIC (genes):WASL WASL

CTD Gene:8976 WASL

dbSNP Gene:8976 WASL

ENSEMBL:ENSG00000106299 WASL

HGNC:12735 WASL

KEGG:hsa:8976 WASL

Monarch:8976 WASL

NCBI Gene:8976 WASL

OMIM:605056 WASL

UCSC:O00401 WASL

Reference Transcript

RefSeq:NM_003941.3 WASL

Other Identifiers

11717284_a_at

11717285_a_at

11754385_s_at

17062460

205809_PM_s_at

205809_s_at

205810_PM_s_at

205810_s_at

224813_PM_at

224813_at

3070714

3070715

3070716

3070717

3070721

3070722

3070727

3070728

3070729

3070730

3070731

3070732

3070735

3070736

3070737

3070750

3070751

3070752

3070753

3070754

3070755

3070756

321_at

39875_at

44736_at

8142671

8976

A_33_P3405444

D88460_at

GE57430

GO:0003779

GO:0005515

GO:0005634

GO:0005737

GO:0005789

GO:0005829

GO:0005856

GO:0005886

GO:0006355

GO:0006900

GO:0007010

GO:0007015

GO:0008017

GO:0008092

GO:0008154

GO:0009617

GO:0015629

GO:0016050

GO:0030027

GO:0030036

GO:0030041

GO:0030050

GO:0030478

GO:0030666

GO:0030695

GO:0031410

GO:0031503

GO:0032880

GO:0043226

GO:0045944

GO:0051301

GO:0051491

GO:0051653

GO:0060997

GO:0061024

GO:0065003

GO:0070062

GO:0098772

GO:0098978

GO:0099175

GO:1903526

GO:2000370

GO:2000402

HMNXSV003030896

Hs.170065.0.S1_3p_at

Hs.288830.0.A1_3p_a_at

ILMN_1666004

TC07001823.hg

g4505322_3p_a_at

Participates

as a member of

p-Y291-WASP/p-Y256-N-WASP [cytosol] (Homo sapiens)

Other forms of this molecule

N-WASP [cytosol]

WASL [plasma membrane]

WASL [endocytic vesicle membrane]

Inferred To

phospho-WASL [cytosol] (Bos taurus)

phospho-WASL [cytosol] (Canis familiaris)

phospho-WASL [cytosol] (Gallus gallus)

phospho-WASL [cytosol] (Sus scrofa)

phospho-wasla [cytosol] (Danio rerio)

Modified Residues

Name

O4'-phospho-L-tyrosine at 256

Coordinate

256

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_003932.3

OpenTargets

ENSG00000106299

ENSEMBL

ENST00000223023, ENSP00000223023

HPA

ENSG00000106299-WASL

PRO

O00401

Pharos - Targets

O00401

GlyGen

O00401

PDB

4CC2, 2FF3, 2VCP, 2LNH, 4CC7

Interactors (44)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.935	12
UniProt:O43516 WIPF1	1	WIPF1 [cytosol] (R-HSA-201874)	0.92	10
UniProt:Q8TF74 WIPF2	1	WIPF2 [cytosol] (R-HSA-2197666)	0.847	8
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.832	9
UniProt:O76064 RNF8	1	RNF8 [nucleoplasm] (R-HSA-5682539)	0.83	8
UniProt:P60953 CDC42	3	CDC42 [cytosol] (R-HSA-442630) CDC42 [plasma membrane] (R-HSA-449545) CDC42 [endoplasmic reticulum membrane] (R-HSA-5672086)	0.75	4
UniProt:A6NGB9 WIPF3	1	WIPF3 [cytosol] (R-HSA-2197670)	0.738	4
UniProt:O00560 SDCBP	3	SDCBP [cytosol] (R-HSA-373639) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [extracellular region] (R-HSA-6806206)	0.718	6
UniProt:Q9H4E5 RHOJ	1	RHOJ [plasma membrane] (R-HSA-3006725)	0.718	6
UniProt:O15145 ARPC3	1	ARPC3 [cytosol] (R-HSA-200812)	0.718	6
UniProt:Q15811 ITSN1	1	ITSN1 [cytosol] (R-HSA-3006481)	0.704	5
UniProt:P61157 ACTR3	1	ARP3 [cytosol] (R-BTA-419940)	0.702	3
UniProt:Q8X482 ESPFU			0.691	5
UniProt:P16333 NCK1	2	NCK1 [plasma membrane] (R-HSA-202992) NCK1 [cytosol] (R-HSA-197954)	0.669	4
UniProt:Q99828 CIB1			0.633	7
UniProt:P0DJ88 ESFU2			0.623	2
UniProt:O96013 PAK4	1	PAK4 [cytosol] (R-HSA-428461)	0.619	8
UniProt:P68135 ACTS			0.609	2
UniProt:O15143 ARPC1B	1	ARPC1B [cytosol] (R-HSA-6787770)	0.609	2
UniProt:O60504-2 SORBS3			0.589	3
UniProt:Q6XZF7-1 DNMBP			0.558	2
UniProt:Q9UKS6 PACSIN3	1	PACSIN3 [cytosol] (R-HSA-8868270)	0.556	3
UniProt:Q9NYB9-2 ABI2			0.556	5
UniProt:A0A0S2Z4D7 A0A0S2Z4D7			0.556	3
UniProt:Q13882 PTK6	5	PTK6 [cytosol] (R-HSA-8848000) p-Y342-PTK6 [cytosol] (R-HSA-8848007) p-Y342-PTK6 [nucleoplasm] (R-HSA-8848937) p-Y351-PTK6 [cytosol] (R-HSA-8857570) p-Y342,Y447-PTK6 [cytosol] (R-HSA-8849103)	0.556	3
UniProt:Q8TF42 UBS3B			0.556	3
IntAct:EBI-16429374 CCSB ISOFORM ID			0.556	3
IntAct:EBI-22313194 CCSB ORF ID			0.556	3
UniProt:Q9UNF0 PACSIN2	1	PACSIN2 [cytosol] (R-HSA-8868267)	0.556	3
UniProt:E7ERP6 E7ERP6			0.556	3
IntAct:EBI-22315148 CCSB ORF ID			0.556	3
UniProt:Q8IWW6-4 ARHGAP12			0.556	3
UniProt:P57075-2 UBASH3A			0.556	3
UniProt:Q15642-2 TRIP10			0.556	5
UniProt:O94875-10 SORBS2			0.556	3
UniProt:P59998 ARPC4	1	ARPC4 [cytosol] (R-HSA-200813)	0.556	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:Q9UQB8 BAIAP2	1	BAIAP2 [cytosol] (R-HSA-442574)	0.547	2
UniProt:Q9ESJ4	1	Nckipsd [cytosol] (R-MMU-2197671)	0.544	2
UniProt:Q96DT6 ATG4C	1	ATG4C [cytosol] (R-HSA-5671863)	0.527	2
UniProt:P06276 BCHE	2	BCHE [plasma membrane] (R-HSA-3640835) BCHE [extracellular region] (R-HSA-434469)	0.527	2
UniProt:Q8R511	1	Fnbp1 [cytosol] (R-RNO-8862261)	0.524	2
UniProt:Q9Y5X1 SNX9	3	SNX9 [cytosol] (R-HSA-8867737) SNX9 [Golgi membrane] (R-HSA-432988) SNX9 [cytoplasmic vesicle membrane] (R-HSA-432990)	0.524	2
UniProt:P16333-1 NCK1			0.499	2

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