Reactome | Src phosphorylate WASP,N-WASP

Src phosphorylate WASP,N-WASP

Stable Identifier

R-HSA-2197698

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Parasite infection (Homo sapiens)
        
        Leishmania phagocytosis (Homo sapiens)
        
        FCGR3A-mediated phagocytosis (Homo sapiens)
        
        Src phosphorylate WASP,N-WASP (Homo sapiens)

General

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WASP is phosphorylated on Tyr291 (Cory et al. 2002) and N-WASP (WASL) on Tyr256 (Wu et al. 2004) by Src family of tyrosine kinases and this phosphorylation may release the autoinhibitory intramolecular interactions. The phosphorylation seems to be enhanced by the activation of CDC42. WASP phosphorylation and binding of CDC42 have a synergistic effect on the activation of the ARP2/3 complex (Takenawa & Suetsugu 2007). In N-WASP, the phosphorylation may reduce its nuclear translocation and may sustain it in its functional site in the cytoplasm (Wu et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
12235133	Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich Syndrome protein Cory, GO, Garg, R, Cramer, R, Ridley, AJ	J Biol Chem	2002
14676198	Focal adhesion kinase regulation of N-WASP subcellular localization and function Wu, X, Suetsugu, S, Cooper, LA, Takenawa, T, Guan, JL	J Biol Chem	2004