STAB1 (FEEL-1) binds ligands

Stable Identifier
R-HSA-2197770
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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STAB1 (FEEL-1) binds acetylated low density lipoprotein (LDL) (Adachi & Tsujimoto 2002, Palani et al. 2011), phosphatidylserine (exposed when cells are lysed) (Park et al. 2009), advanced glycation end products (AGE) (Tamura et al. 2003, Hansen et al. 2005), and Osteonectin (SPARC) (Kzhyshkowska et al. 2006).

Literature References
PubMed ID Title Journal Year
15572036 Stabilin-1 and stabilin-2 are both directed into the early endocytic pathway in hepatic sinusoidal endothelium via interactions with clathrin/AP-2, independent of ligand binding

Hansen, B, Longati, P, Elvevold, K, Nedredal, GI, Schledzewski, K, Olsen, R, Falkowski, M, Kzhyshkowska, J, Carlsson, F, Johansson, S, Johansson, S, Smedsrød, B, Goerdt, S, McCourt, P

Exp Cell Res 2005
16670288 Novel function of alternatively activated macrophages: stabilin-1-mediated clearance of SPARC

Kzhyshkowska, J, Workman, G, Cardó-Vila, M, Arap, W, Pasqualini, R, Gratchev, A, Krusell, L, Goerdt, S, Sage, EH

J Immunol 2006
19726632 Stabilin-1 mediates phosphatidylserine-dependent clearance of cell corpses in alternatively activated macrophages

Park, SY, Jung, MY, Lee, SJ, Kang, KB, Gratchev, A, Riabov, V, Kzhyshkowska, J, Kim, IS

J Cell Sci 2009
12473645 FEEL-1 and FEEL-2 are endocytic receptors for advanced glycation end products

Tamura, Y, Adachi, H, Osuga, J, Ohashi, K, Yahagi, N, Sekiya, M, Okazaki, H, Tomita, S, Iizuka, Y, Shimano, H, Nagai, R, Kimura, S, Tsujimoto, M, Ishibashi, S

J Biol Chem 2003
12077138 FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis-modulating activities

Adachi, H, Tsujimoto, M

J Biol Chem 2002
21480214 Stabilin-1/CLEVER-1, a type 2 macrophage marker, is an adhesion and scavenging molecule on human placental macrophages

Palani, S, Maksimow, M, Miiluniemi, M, Auvinen, K, Jalkanen, S, Salmi, M

Eur J Immunol 2011
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