TRIF signaling activates TRAF3 self-mediated polyubiquitination trough Lys-63 of ubiquitin. The ubiquitinated TRAF3 in turn activates the interferon response (Tseng PH et al. 2010).
Mino, T, Matsuzawa, A, Karin, M, Zhang, W, Tseng, PH, Vignali, DA
ubiquitin-protein transferase activity of TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
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