Auto-ubiquitination of TRAF3

Stable Identifier
R-HSA-2213017
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
endosome membrane, cytosol
ReviewStatus
5/5
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Auto-ubiquitination of TRAF3
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TRIF signaling activates TRAF3 self-mediated polyubiquitination trough Lys-63 of ubiquitin. The ubiquitinated TRAF3 in turn activates the interferon response (Tseng PH et al. 2010).

Literature References
PubMed ID Title Journal Year
19898473 Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines

Mino, T, Matsuzawa, A, Karin, M, Zhang, W, Tseng, PH, Vignali, DA

Nat Immunol 2010
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Output
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as an event of
Catalyst Activity

ubiquitin-protein transferase activity of TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]

Physical Entity
TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Orthologous Events
Auto-ubiquitination of TRAF3 (Bos taurus)
Auto-ubiquitination of TRAF3 (Canis familiaris)
Auto-ubiquitination of TRAF3 (Gallus gallus)
Auto-ubiquitination of TRAF3 (Mus musculus)
Auto-ubiquitination of TRAF3 (Sus scrofa)
Authored
Shamovsky, V  (2012-04-26)
Reviewed
Fitzgerald, KA  (2012-11-13)
D'Eustachio, P  (2012-05-25)
Masci, A M  (2014-05-16)
Created
Shamovsky, V  (2012-04-27)
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