Collagen VII forms anchoring fibrils, composed of antiparallel dimers that connect the dermis to the epidermis (Bruckner-Tuderman 2009). During fibrillogenesis, the nascent type VII procollagen molecules dimerize in an antiparallel manner. The C-propeptides are then removed by bone morphogenetic protein 1 (Rattenholl et al. 2002) and the processed antiparallel dimers laterally aggregate (Gordon & Hahn 2010).
Bruckner-Tuderman, L, Koch, M, Rattenholl, A, Keene, DR, Burgeson, RE, Greenspan, DS, Pappano, WN, Kadler, KE, Timpl, R, Sasaki, T
© 2023 Reactome
