Collagens XV and XVIII are basement membrane associated collagens that can be cleaved to generate the antiangiogenic peptides restin (endostatin-XV) and endostatin (endostatin-XVIII), respectively (O'Reilly et al. 1997, Ramachandran et al. 1997, Sasaki et al. 2000). Endostatin fragments of differing molecular size (14-30 kDa) have been identified in vivo. Furthermore the C-terminal domains of several other collagens (IV, VIII, XIX) have anti-angiogenic and anti-tumoral activities (Ricard-Blum & Ballut 2011). Several proteases are able to generate endostatin from collagen XVIII including MMP-3, -7, -9, -13 and -20 and cathepsins B, V, S and L (Heljasvaara et al. 2005, Ma et al. 2007, Veillard et al. 2011). Endostatin inhibits proliferation of endothelial cells, angiogenesis and tumor growth in vivo (O'Reilly et al. 1997).
Larsson, H, Hohenester, E, Tisi, D, Claesson-Welsh, L, Timpl, R, Sasaki, T
Vasios, G, Fukai, N, Lane, WS, O'Reilly, MS, Flynn, E, Boehm, T, Olsen, BR, Folkman, J, Birkhead, JR, Shing, Y
endopeptidase activity of Endostatin releasing proteases [extracellular region]
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