Reactome | Type XII and XIV collagens associate with type I and type II fibrils.

Type XII and XIV collagens associate with type I and type II fibrils.

Stable Identifier

R-HSA-2213205

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

extracellular region

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Type XII and XIV collagens associate with type I and type II fibrils.

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Certain fibril-associated collagens with interrupted triple helices (FACITs) associate with the surface of collagen fibrils, where they may serve to limit fibril fusion and thereby regulate fibril diameter (Ansorge et al. 2009, Gordon & Hahn 2010). Type XII and XIV colalgens are found in association with type I (Walchli et al. 1994) and type II (Watt et al. 1992, Eyre 2002).

Literature References

PubMed ID	Title	Journal	Year
8207089	Tissue-specific expression of the fibril-associated collagens XII and XIV Wälchli, C, Odermatt, BF, Chiquet, M, Koch, M, Trueb, B	J Cell Sci	1994
1400327	Characterization of collagen types XII and XIV from fetal bovine cartilage Lunstrum, GP, Keene, DR, Burgeson, RE, McDonough, AM, Watt, SL, Morris, NP	J Biol Chem	1992