PDPK1 (PDK1) possesses low affinity for PIP2, so small amounts of PDPK1 are always present at the membrane, in the absence of PI3K activity (Currie et al. 1999).
Alessi, DR, Cohen, P, Downes, CP, Casamayor, A, Lucocq, J, Currie, RA, Deak, M, Gray, A, Walker, KS
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