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CTSD(65-161) [extracellular region]
Stable Identifier
R-HSA-2228718
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Cathepsin D light chain, CTSD, CATD_HUMAN
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Degradation of the extracellular matrix (Homo sapiens)
Collagen degradation (Homo sapiens)
Endostatin degradation by cathepsins (Homo sapiens)
Endostatin-degrading cathepsins [extracellular region] (Homo sapiens)
Cathepsin D dimer [extracellular region] (Homo sapiens)
CTSD(65-161) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P07339 CTSD
Gene Names
CTSD, CPSD
Chain
signal peptide:1-20, propeptide:21-64, chain:65-412, chain:65-162, chain:169-412
Reference Genes
BioGPS Gene:1509 CTSD
COSMIC (genes):CTSD CTSD
CTD Gene:1509 CTSD
dbSNP Gene:1509 CTSD
ENSEMBL:ENSG00000117984 CTSD
ENSEMBL_homo_sapiens_GENE:ENSG00000117984.15 CTSD
HGNC:2529 CTSD
KEGG Gene (Homo sapiens):1509 CTSD
Monarch:1509 CTSD
NCBI Gene:1509 CTSD
OMIM:116840 CTSD
Reference Transcript
RefSeq:NM_001909.4 CTSD
Other Identifiers
11755925_s_at
11757307_s_at
11757848_s_at
1509
16734313
200766_3p_at
200766_PM_at
200766_at
239_at
3358964
3358965
3358966
3358967
3358968
3358969
3358971
3358972
3358974
3358975
3358976
3358977
3358979
3358982
3358983
7945666
A_23_P52556
A_33_P3243907
GE61336
GO:0000045
GO:0002376
GO:0003824
GO:0004175
GO:0004190
GO:0004197
GO:0005515
GO:0005576
GO:0005615
GO:0005764
GO:0005765
GO:0005768
GO:0005773
GO:0006508
GO:0006914
GO:0008233
GO:0010008
GO:0012501
GO:0016787
GO:0019886
GO:0023052
GO:0030163
GO:0030312
GO:0031012
GO:0031410
GO:0031904
GO:0035580
GO:0038020
GO:0042159
GO:0042470
GO:0043065
GO:0043202
GO:0043226
GO:0043280
GO:0045121
GO:0062023
GO:0070001
GO:0070062
GO:0070201
GO:0140096
GO:1901143
GO:1904724
GO:1904813
ILMN_1674038
M63138_at
PH_hs_0016632
TC11003472.hg
g4503142_3p_at
g4503142_3p_x_at
Participates
as a component of
Cathepsin D dimer [extracellular region] (Homo sapiens)
Other forms of this molecule
CTSD(65-161) [lysosomal lumen]
CTSD(65-412) [extracellular region]
CTSD(65-412) [plasma membrane]
CTSD(65-412) [tertiary granule lumen]
CTSD(65-412) [ficolin-1-rich granule lumen]
CTSD(65-412) [specific granule lumen]
CTSD(169-412) [endosome lumen]
CTSD(65-161) [endosome lumen]
CTSD(169-412) [extracellular region]
CTSD(65-412) [lysosomal lumen]
CTSD(169-412) [lysosomal lumen]
Inferred To
Ctsd [extracellular region]
(Mus musculus)
Ctsd [extracellular region]
(Rattus norvegicus)
CTSD [extracellular region]
(Bos taurus)
CTSD [extracellular region]
(Canis familiaris)
CTSD [extracellular region]
(Sus scrofa)
Cross References
RefSeq
NP_001900.1
Guide to Pharmacology - Targets
2345
OpenTargets
ENSG00000117984
ZINC - Substances
CATD_HUMAN
ZINC - Biogenic
CATD_HUMAN
ZINC target
P07339
PRO
P07339
PDB
4OD9
,
4OBZ
,
1LYA
,
1LYW
,
4OC6
,
1LYB
ZINC - Investigational
CATD_HUMAN
IntEnz
3.4.23.5
HPA
ENSG00000117984-CTSD
GeneCards
P07339
Ensembl
ENSG00000117984
,
ENST00000236671
,
ENSP00000236671
Pharos - Targets
P07339
ZINC - Predictions - Purchasable
CATD_HUMAN
Orphanet
17343
HMDB Protein
HMDBP02285
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8NBJ7 SUMF2
1
SUMF2 [endoplasmic reticulum lumen]
(R-HSA-1614305)
0.556
3
UniProt:O00308 WWP2
1
WWP2 [cytosol]
(R-HSA-6807279)
0.556
3
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
7
UniProt:P04578 env
7
Surface protein gp120 (P04578) [cytosol]
(R-HIV-189269)
Transmembrane protein gp41 (P04578) [cytosol]
(R-HIV-189359)
Glycosylated Envelope glycoprotein gp160 [Golgi membrane]
(R-HIV-3149443)
Envelope glycoprotein gp160 [endoplasmic reticulum membrane]
(R-HIV-189343)
Transmembrane protein gp41 [viral envelope]
(R-HIV-171195)
ENV [viral envelope]
(R-HIV-173439)
Surface protein gp120 [viral envelope]
(R-HIV-171211)
0.462
2
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